ChemicalBook > CAS DataBase List > Lotilaner
Lotilaner
- Product Name
- Lotilaner
- CAS No.
- 1369852-71-0
- Chemical Name
- Lotilaner
- Synonyms
- Lothilana;Lotilaner;D4-Lotilaner;Lotilaner (TP-05);Lotilaner Impurity2;Lotilaner, 10 mM in DMSO;Parasite,Inhibitor,γ-Aminobutyric acid Receptor,Lotilaner,inhibit,Gamma-aminobutyric acid Receptor,GABA Receptor;(S)-3-Methyl-N-(2-oxo-2-((2,2,2-trifluoroethyl)a mino)ethyl)-5-(5-(3,4,5-trichlorophenyl)-5-(trifluo romethyl)-4,5-dihydroisoxazol-3-yl)thiophene-2- carboxamide;2-Thiophenecarboxamide, 5-[(5S)-4,5-dihydro-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-3-isoxazolyl]-3-methyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-;(S)-5-[5-(3,4,5-trichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-3-methyl-thiophene-2-carboxylic acid [(2,2,2-trifluoro-ethylcarbamoyl)-methyl]-amide
- CBNumber
- CB73344768
- Molecular Formula
- C20H14Cl3F6N3O3S
- Formula Weight
- 596.76
- MOL File
- 1369852-71-0.mol
More
Less
Lotilaner Property
- Density
- 1.66±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 100 mg/mL (167.57 mM)
- form
- Solid
- pka
- 12.52±0.46(Predicted)
- color
- White to off-white
- InChIKey
- HDKWFBCPLKNOCK-SFHVURJKSA-N
- SMILES
- C1(C(NCC(=O)NCC(F)(F)F)=O)SC(C2C[C@](C3=CC(Cl)=C(Cl)C(Cl)=C3)(C(F)(F)F)ON=2)=CC=1C
More
Less
N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0065903
- Product name
- Lotilaner
- Purity
- 99.60%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0065903
- Product name
- Lotilaner
- Purity
- 99.60%
- Packaging
- 10mg
- Price
- $550
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0065903
- Product name
- Lotilaner
- Purity
- 99.60%
- Packaging
- 50mg
- Price
- $1650
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0065903
- Product name
- Lotilaner
- Purity
- 99.60%
- Packaging
- 100mg
- Price
- $2250
- Updated
- 2021/12/16
More
Less
Lotilaner Chemical Properties,Usage,Production
Description
Lotilaner is a representative of the isoxazolines, a new class of insecticides discovered in the 2000s.
Isoxazolines (Afoxolaner, Fluralaner, Lotilaner, and Sarolaner) Isoxazolines are insecticidal and arachnicidal substances that can be given orally, or topically as spot-ons, and act systemically in the blood circulation.
lotilaner (Credeliot), a novel oral isoxazoline against naturally occurring mange mite infestations in dogs caused by Demodex spp.
Lotilaner, like the other isooxazolines is active against fleas, mites, and ticks. After oral administration or topical application, it can kill fleas rapidly.
Uses
Lotilaner is a new member of the isoxazoline class for the treatment of flea and tick infestations in cats.
Indications
Lotilaner is a monthly chewable tablet for the treatment and prevention of fleas and ticks. It is used in dogs and puppies 8 weeks of age or older weighing 4.4 pounds or greater (Elanco, 2019).
Side effects
These include weight loss, elevated blood urea nitrogen, increased urination, and diarrhea (Elanco, 2019).
Mode of action
Lotilaner is available for oral administration to dogs (CREDELIO), i.e. it has a systemic mode of action. Ingested lotilaner is rapidly absorbed into blood and distributed throughout the whole body of the treated dog. Blood-sucking parasites (mainly fleas and ticks) are killed during their blood meal.
But the systemic mode of action means also that for fleas and/or ticks to be killed, they have to bite the dog first and suck enough blood before the ingested active ingredient kills them.
As other isoxazolines with insecticidal and tickicidal efficacy, lotilaner is a non-competitive GABA (gamma-aminobutyric acid) receptor antagonist, much more selective for GABA receptors in insects or ticks, than for those in mammals, including humans. It binds to chloride channels in nerve and muscle cells, which blocks the transmission of neuronal signals. Affected parasites are paralyzed and die.
Lotilaner Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
Lotilaner Suppliers
- Tel
- 028-87439248 19150327610
- Fax
- 028-87439248
- 553691721@qq.com
- Country
- China
- ProdList
- 64
- Advantage
- 58
- Tel
- 15952038335 13327728092
- xu_meiqin@petmedtech.com
- Country
- China
- ProdList
- 30
- Advantage
- 58
- Tel
- 0531-88901705 18753193522
- 810353473@qq.com
- Country
- China
- ProdList
- 159
- Advantage
- 58
- Tel
- 17336178085
- 1684779048@qq.com
- Country
- China
- ProdList
- 1837
- Advantage
- 58
- Tel
- 028-87827187 18681376319
- sales@eastonpharma.cn
- Country
- China
- ProdList
- 66
- Advantage
- 60
- Tel
- 27-027-83314682 13554138826
- Fax
- +86 (27) 8331-4682
- whsrtech@vip.163.com
- Country
- China
- ProdList
- 246
- Advantage
- 62
- Tel
- 0531-0531-58897003 15550412551
- Fax
- 0531-58897003
- market@jnchsd.com
- Country
- China
- ProdList
- 229
- Advantage
- 62
- Tel
- 028-81700200 18116577057
- Fax
- 028-81705658
- 3003855609@qq.com
- Country
- China
- ProdList
- 7778
- Advantage
- 56
- Tel
- 0571-87396432
- Fax
- 0571-87396431
- sales@jhechem.com
- Country
- China
- ProdList
- 14912
- Advantage
- 59
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4757
- Advantage
- 55
- Tel
- 17764003753
- Fax
- 13669031409
- 2326587775@qq.com
- Country
- China
- ProdList
- 188
- Advantage
- 55
- Tel
- 17764003753
- Fax
- 13669031409
- 2326587775@qq.com
- Country
- China
- ProdList
- 188
- Advantage
- 55
- Tel
- 028-67271278 18628360895
- Fax
- 0575-89298961
- sales@artisbio.com
- Country
- China
- ProdList
- 1960
- Advantage
- 58
- Tel
- 0317-5296180 15533709196
- Fax
- 0317-5106596
- sale@enkepharma.com
- Country
- China
- ProdList
- 2267
- Advantage
- 55
- Tel
- 021-31433387 15618786686
- Fax
- QQ:1369748377
- sales@rechemscience.com
- Country
- China
- ProdList
- 2989
- Advantage
- 58
- Tel
- 18701958033
- Fax
- 021-60441077
- shzxchem@163.com
- Country
- China
- ProdList
- 649
- Advantage
- 58
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12306
- Advantage
- 58
- Tel
- 531-58897070 15254140813
- Fax
- 0531-58897046
- market@jnchsd.com
- Country
- China
- ProdList
- 235
- Advantage
- 58
- Tel
- +86-0531-88803416 13153166250
- Fax
- 0531-88803416
- sales@chemedpharma.com
- Country
- China
- ProdList
- 199
- Advantage
- 58
- Tel
- 15966937598
- Fax
- 3407640895 3071519937
- 3407650895@qq.com
- Country
- China
- ProdList
- 2274
- Advantage
- 58
- Tel
- 0531-58897130 15508676053
- drug_impurity@sdcclh.com
- Country
- China
- ProdList
- 2268
- Advantage
- 58
- Tel
- 029-88380327 17691182729
- Fax
- 029-88380327
- 1018@dideu.com
- Country
- China
- ProdList
- 2011
- Advantage
- 58
- Tel
- 13316949107 13316968096
- 1979313431@qq.com
- Country
- China
- ProdList
- 9564
- Advantage
- 58
- Tel
- 15911056312
- liming@bio-fount.com
- Country
- China
- ProdList
- 9729
- Advantage
- 58
- Tel
- +8618530059196
- sale04@alfachem.cn
- Country
- China
- ProdList
- 11784
- Advantage
- 58
- Tel
- +862156762820 +86-13564624040
- sales@myuchem.com
- Country
- China
- ProdList
- 8460
- Advantage
- 58
- Tel
- 029-89275612 +8618991951683
- Fax
- 8618991951683
- mcbio_sales@163.com
- Country
- China
- ProdList
- 2251
- Advantage
- 58
- Tel
- +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10473
- Advantage
- 58
- Tel
- +86-027-59207850 +86-13986145403;
- Fax
- 86-27-59524646
- info@fortunachem.com
- Country
- China
- ProdList
- 5987
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0371-86658258
- laboratory@coreychem.com
- Country
- China
- ProdList
- 30229
- Advantage
- 58
- Tel
- 18201884268
- magean83@163.com
- Country
- China
- ProdList
- 1959
- Advantage
- 58
- Tel
- 021-021-13773155751 19975051755
- 260924549@qq.com
- Country
- China
- ProdList
- 10524
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11218
- Advantage
- 58
- Tel
- +86-29-81148696 +86-17392712697
- 1022@dideu.com
- Country
- China
- ProdList
- 3995
- Advantage
- 58
- Tel
- 020-82000279 18988941452
- Fax
- QQ：3283937693
- YN_research@163.com
- Country
- China
- ProdList
- 3011
- Advantage
- 58
- Tel
- 88888888888
- hongquchem@qq.com
- Country
- China
- ProdList
- 5132
- Advantage
- 58
- Tel
- 15307151931
- Fax
- QQ-2355680
- 2355680@qq.com
- Country
- China
- ProdList
- 5831
- Advantage
- 58
- Tel
- 0755-0755-83725350 13380397412
- Fax
- 0755-28094224
- 3001280422@qq.com
- Country
- China
- ProdList
- 10001
- Advantage
- 58
- Tel
- 022-23869539 18920052327
- Fax
- 022-83711180
- 281258989@qq.com
- Country
- China
- ProdList
- 63
- Advantage
- 58
- Tel
- 15871722230
- Fax
- 2796190295
- 15871722230@163.com
- Country
- China
- ProdList
- 4686
- Advantage
- 58
- Tel
- 15120707353
- 303772480@qq.com
- Country
- China
- ProdList
- 10
- Advantage
- 58
- Tel
- 027-68897569 18120462897
- Fax
- 027-68897569
- fiona@yuanmengbio.com
- Country
- China
- ProdList
- 4657
- Advantage
- 58
- Tel
- 021-61109150
- Fax
- 021-61105897
- sales@tcisct.com
- Country
- China
- ProdList
- 29668
- Advantage
- 58
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29757
- Advantage
- 58
- Tel
- 400-880-2824; 13184580281
- Fax
- 400-880-2824
- hj@ruiweier.cn
- Country
- China
- ProdList
- 2686
- Advantage
- 58
- Tel
- 027-59102966 18717199209
- Fax
- 027-59379337
- 2853877583@qq.com
- Country
- China
- ProdList
- 2715
- Advantage
- 58
- Tel
- 18053179586
- export@anstarchemical.com
- Country
- China
- ProdList
- 372
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 59936
- Advantage
- 58
- Tel
- 13549236410
- sales@invivochem.cn
- Country
- China
- ProdList
- 6753
- Advantage
- 58
- Tel
- 19972070065
- 201746457@qq.com
- Country
- China
- ProdList
- 6428
- Advantage
- 58
More
Less
View Lastest Price from Lotilaner manufacturers
Wuhan Haorong Biotechnology Co.,Ltd
- Product
- Lotilaner 1369852-71-0
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000
- Release date
- 2025-07-03
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
- Product
- Lotilaner 1369852-71-0
- Price
- US $2.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-18
Wuhan JiyunZen Tech Co., Ltd.
- Product
- Lotilaner 1369852-71-0
- Price
- US $5.00-0.50/KG
- Min. Order
- 1KG
- Purity
- 99% hplc
- Supply Ability
- 500TONS
- Release date
- 2025-06-05