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DS-1040 (Tosylate)

Product Name
DS-1040 (Tosylate)
CAS No.
1335138-89-0
Chemical Name
DS-1040 (Tosylate)
Synonyms
DS-1040 (Tosylate);DS-1040 tosylate (DS 1040;DS 1040 Tosylate,DS1040 Tosylate
CBNumber
CB73356149
Molecular Formula
C23H35N3O5S
Formula Weight
465.61
MOL File
1335138-89-0.mol
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DS-1040 (Tosylate) Property

storage temp. 
Store at -20°C
form 
Solid
color 
White to off-white
Water Solubility 
Water: 100 mg/mL (214.77 mM)
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Hazard and Precautionary Statements (GHS)

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DS-1040 (Tosylate) Chemical Properties,Usage,Production

Description

DS-1040 Tosylate is an inhibitor of the activated thrombin-activatable fibrinolysis inhibitor (TAFIa), used for the treatment of acute ischemic stroke (AIS).

Uses

DS-1040 Tosylate is an orally active, selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC50s of 5.92 nM and 8.01 nM for human and rat TAFIa. DS-1040 Tosylate is a fibrinolysis enhancer for thromboembolic diseases[1].

in vivo

DS-1040 Tosylate (0.0005-0.5 mg/kg; IV) significantly reduces the microthrombi index at doses of 0.005 mg/kg and greater[1].
DS1040 (0.016, 0.031, 0.063, 0.13, 0.25, 0.50 mg/kg; i.v.) increases plasma D-dimer levels in a dose-dependent manner in the microthrombosis model. ED50 and EDmax are 122 and 221 nmol/L, respectively[1].
DS-1040 (0.25, 0.5, 1, 2, 4, 8, 16 mg/kg; orally) also increases plasma D-dimer levels. EC50 and ECmax values are 114 and 231 nmol/L, respectively[1].

Animal Model:Male Slc:Wistar rats[1]
Dosage:0.0005, 0.005, 0.05, 0.5 mg/kg
Administration:IV
Result:Significantly reduced the microthrombi index at doses of 0.005 mg/kg and greater.

References

[1]. Zhou J, et al. A first-in-human study of DS-1040, an inhibitor of the activated form of thrombin-activatable fibrinolysis inhibitor, in healthy subjects. J Thromb Haemost. 2017 May;15(5):961-971.

DS-1040 (Tosylate) Preparation Products And Raw materials

Raw materials

Preparation Products

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DS-1040 (Tosylate) Suppliers

CHINA 9 United States 3 Global 12
MedChemexpress LLC
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TargetMol Chemicals Inc.
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Guangzhou Xinghe Biotechnology Co., Ltd.
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1335138-89-0, DS-1040 (Tosylate)Related Search:


  • DS-1040 (Tosylate)
  • DS-1040 tosylate (DS 1040
  • DS 1040 Tosylate,DS1040 Tosylate
  • 1335138-89-0