GIBH-130

Product Name: GIBH-130
CAS No.: 1252608-59-5
Chemical Name: GIBH-130
Synonyms: GIBH-130;GIBH-130, 10 mM in DMSO;GIBH-130;GIBH 130;GIBH130;GIBH130,Inhibitor,Interleukin Related,GIBH 130,inhibit,GIBH-130;4-methyl-6-phenyl-3-[4-(pyrimidin-2-yl)piperazine-1-carbonyl]pyridazine;(4-methyl-6-phenyl-3-pyridazinyl)[4-(2-pyrimidinyl)-1-piperazinyl]-GIBH-130;Methanone, (4-methyl-6-phenyl-3-pyridazinyl)[4-(2-pyrimidinyl)-1-piperazinyl]-
CBNumber: CB73356154
Molecular Formula: C20H20N6O
Formula Weight: 360.41
MOL File: 1252608-59-5.mol

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GIBH-130 Property

Boiling point:: 664.5±65.0 °C(Predicted)
Density: 1.268±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:50.0(Max Conc. mg/mL);138.73(Max Conc. mM)
Water:0.1(Max Conc. mg/mL);0.28(Max Conc. mM)
form: Solid
pka: 4.87±0.33(Predicted)
color: Off-white to pink

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-7583
Product name: GIBH-130
Purity: 99.95%
Packaging: 2mg
Price: $108
Updated: 2021/12/16

ChemScene

Product number: CS-7583
Product name: GIBH-130
Purity: 99.95%
Packaging: 5mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-7583
Product name: GIBH-130
Purity: 99.95%
Packaging: 10mg
Price: $288
Updated: 2021/12/16

ChemScene

Product number: CS-7583
Product name: GIBH-130
Purity: 99.95%
Packaging: 50mg
Price: $900
Updated: 2021/12/16

ChemScene

Product number: CS-7583
Product name: GIBH-130
Purity: 99.95%
Packaging: 100mg
Price: $1440
Updated: 2021/12/16

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GIBH-130 Chemical Properties,Usage,Production

Uses

GIBH-130 is an effective inhibitor of neuroinflammation. GIBH-130 significantly suppresses the IL-1β secretion by activated microglia (IC50=3.4 nM).

in vivo

GIBH-130 exhibits comparable in vivo efficacy of cognitive impairment relief to donepezil and memantine respectively in both β amyloid-induced and APP/PS1 double transgenic Alzheimer’s murine models at a substantially lower dose (0.25 mg/kg). The pharmacokinetic properties of GIBH-130 are assessed in Sprague-Dawley rats. As a potential drug candidate targeting in CNS, GIBH-130 is found to be orally bioavailable in rats, with 74.91% bioavailability and 4.32 h half-life. In addition, GIBH-130 displays good penetration ability across blood-brain barrier (AUCBrain/Plasma=0.21)^[1].

IC 50

IL-1β: 3.4 nM (IC₅₀)

References

[1] Zhou W, et al. Microglia-Based Phenotypic Screening Identifies a Novel Inhibitor of Neuroinflammation Effective in Alzheimer's Disease Models. ACS Chem Neurosci. 2016 Nov 16;7(11):1499-1507. DOI:10.1021/acschemneuro.6b00125

GIBH-130 Preparation Products And Raw materials

Raw materials

Preparation Products

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GIBH-130 Suppliers

China 48 India 1 United States 4 Global 53

MedChemexpress LLC

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1252608-59-5, GIBH-130Related Search:

GIBH-130

GIBH-130;GIBH 130;GIBH130

Methanone, (4-methyl-6-phenyl-3-pyridazinyl)[4-(2-pyrimidinyl)-1-piperazinyl]-

(4-methyl-6-phenyl-3-pyridazinyl)[4-(2-pyrimidinyl)-1-piperazinyl]-GIBH-130

GIBH130,Inhibitor,Interleukin Related,GIBH 130,inhibit,GIBH-130

4-methyl-6-phenyl-3-[4-(pyrimidin-2-yl)piperazine-1-carbonyl]pyridazine

GIBH-130, 10 mM in DMSO

1252608-59-5