Tropifexor

Product Name: Tropifexor
CAS No.: 1383816-29-2
Chemical Name: Tropifexor
Synonyms: LJN452;CPD1549;CS-2712;LJP-305;Tropifexor;LJN452;CPD1549;LJN452,Tropifexor;Tropifexor (LJN452);LJN 452;LJN-452;LJN452;Tropifexor, 10 mM in DMSO
CBNumber: CB73362023
Molecular Formula: C29H25F4N3O5S
Formula Weight: 603.58
MOL File: 1383816-29-2.mol

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Tropifexor Property

Boiling point:: 700.0±65.0 °C(Predicted)
Density: 1.55±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:80.66(Max Conc. mg/mL);133.64(Max Conc. mM)
form: A crystalline solid
pka: 3.84±0.10(Predicted)
color: Off-white to yellow
InChIKey: VYLOOGHLKSNNEK-JWTNVVGKNA-N
SMILES: S1C2=CC(C(O)=O)=CC(F)=C2N=C1N1[C@@]2([H])CC[C@]1([H])CC(OCC1=C(C3CC3)ON=C1C1=CC=CC=C1OC(F)(F)F)C2 |&1:14,18,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 25748
Product name: Tropifexor
Packaging: 500μg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 25748
Product name: Tropifexor
Packaging: 1mg
Price: $176
Updated: 2024/03/01

Cayman Chemical

Product number: 25748
Product name: Tropifexor
Packaging: 5mg
Price: $775
Updated: 2024/03/01

Cayman Chemical

Product number: 25748
Product name: Tropifexor
Packaging: 10mg
Price: $1184
Updated: 2024/03/01

TRC

Product number: T892505
Product name: Tropifexor
Packaging: 2.5mg
Price: $375
Updated: 2021/12/16

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Tropifexor Chemical Properties,Usage,Production

Uses

Tropifexor, is a highly potent non-bile acid FXR agonist for the treatment of cholestatic liver diseases and nonalcoholic steatohepatitis (NASH).

in vivo

Tropifexor (compound 1) demonstrates highly potent induction of SHP and FGF15 in the ileum as doses as low as 0.1 mg/kg. In the liver, robust induction of SHP is observed at 0.01 mg/kg of Tropifexor with maximal levels of gene induction achieved at 0.3 mg/kg. Expression of CYP8B1 mRNA following 14 day treatment with Tropifexor is already apparent at the lowest dose (0.003 mg/kg), and CYP8B1 gene expression is fully repressed at doses above 0.03 mg/kg.Treatment of rats with Tropifexor exhibits a clear dose-dependent increase in plasma FGF15 protein, with maximal levels of FGF15 detected at 7 h postdose.? Treatment with Tropifexor for 14 days produces a robust dose-dependent reduction in serum triglycerides and reaches a maximal response with a 0.3 mg/kg dose, resulting in a decrease of triglyceride levels to approximately 79% below the vehicle control group^[1].

Tropifexor Preparation Products And Raw materials

Raw materials

Preparation Products

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Tropifexor Suppliers

China 104 United States 7 Global 111

Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd

Tel: 15317229551
Fax: QQ:3607245178
Email: 15151849396@163.com
Country: China
ProdList: 989
Advantage: 58

Bayee Biotech (Anqing) Co., Ltd.

Tel: 0556-5032306 18917961636
Email: wtx@bayeebio.com
Country: China
ProdList: 239
Advantage: 61

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3506
Advantage: 58

Shanghai Xingui Biotechnology Co., Ltd.

Tel: 15121041756
Email: xingui2022@126.com
Country: China
ProdList: 9979
Advantage: 58

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 984
Advantage: 55

Twochem Co.Ltd

Tel: 021-021-58111628 15800915896
Fax: QQ 3285589261
Email: sales@twochem.com
Country: China
ProdList: 304
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

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View Lastest Price from Tropifexor manufacturers

Career Henan Chemical Co

Product: Tropifexor 1383816-29-2
Price: US $9.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg -1000kg
Release date: 2020-01-02

GIHI CHEMICALS CO.,LIMITED

Product: Tropifexor 1383816-29-2
Price: US $2.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 200kgs
Release date: 2019-12-18

1383816-29-2, TropifexorRelated Search:

LJN 452;LJN-452;LJN452

CS-2712

CPD1549

Tropifexor

Tropifexor (LJN452)

LJN452

LJN452,Tropifexor

2-[(1R,3r,5S)-3-({5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl}methoxy)-8-azabicyclo[3.2.1]octan-8-yl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid

2-rel-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid

LJN452;CPD1549

6-Benzothiazolecarboxylic acid, 2-[(3-endo)-3-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-4-isoxazolyl]methoxy]-8-azabicyclo[3.2.1]oct-8-yl]-4-fluoro-

rel-2-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid

2-[(1R,3r,5S)-3-({5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1

3-benzothiazole-6-carboxylic acid

Tropifexor, 10 mM in DMSO

LJP-305

Tropifexor (LJN452) ，S8733

2-((1r,3r,5s)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid

1383816-29-2

C29H25F4N3O5S

API