BAY-598(S-isomer)
- Product Name
- BAY-598(S-isomer)
- CAS No.
- 1906919-67-2
- Chemical Name
- BAY-598(S-isomer)
- Synonyms
- CS-2678;CPD1616;BAY-598;(S)-BAY-598;BAY-598 (BAY598;BAY-598(S-isomer);BAY-598, 10 mM in DMSO;BAY-598,Inhibitor,BAY598,inhibit,Histone Methyltransferase,BAY 598;(S)-N-(1-(N-Cyano-N'-(3-(difluoromethoxy)phenyl)carbamimidoyl)-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-4-yl)-N-ethyl-2-hydroxyacetamide;(S)-N-(1-(N-Cyano-N'-(3-(difluoromethoxy)phenyl)carbamimidoyl)-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-4-yl)-N-ethyl-2-hydroxyacetamide
- CBNumber
- CB73364108
- Molecular Formula
- C22H20Cl2F2N6O3
- Formula Weight
- 525.34
- MOL File
- 1906919-67-2.mol
BAY-598(S-isomer) Property
- Boiling point:
- 663.5±65.0 °C(Predicted)
- Density
- 1.46±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO:69.18(Max Conc. mg/mL);131.69(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);57.11(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);57.11(Max Conc. mM) - pka
- 13.34±0.10(Predicted)
- form
- powder
- color
- white to beige
- optical activity
- [α]/D -85 to -95°, c = 1 in methanol
N-Bromosuccinimide Price
- Product number
- SML1603
- Product name
- BAY-598
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $125.2
- Updated
- 2024/03/01
- Product number
- SML1603
- Product name
- BAY-598
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $585.6
- Updated
- 2024/03/01
- Product number
- 18238
- Product name
- BAY 598
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 18238
- Product name
- BAY 598
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $65
- Updated
- 2024/03/01
- Product number
- 18238
- Product name
- BAY 598
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $266
- Updated
- 2024/03/01
BAY-598(S-isomer) Chemical Properties,Usage,Production
Uses
BAY-598 is an aminopyrazoline-based novel substrate-competitive inhibitor of protein lysine methyltransferase SMYD2 that serves as potent and selective in vivo probe for SMYD2.
Biochem/physiol Actions
BAY-598 is a potent, peptide-competitive chemical probe for SET and MYND domain-containing protein 2 (SMYD2), a lysine methyl transferase inhibitor that dimethylates histone H3K36 and methylates histone H3K4. SMYD2 also methylates Lys-370 of p53, leading to decreased DNA-binding activity. SMYD2 is over-expressed in several cancers with poor prognosis. BAY-598 inhibits in vitro methylation of p53K370 with an IC50 value of 27 nM and in cells with an IC50 value < 1 μM. BAY-598 is more than 100-fold selective over other histone methyltransferases and non-epigenetic targets. BAY-598 can be used with in vivo experiments. For full characterization details, please visit the BAY-598 probe summary on the Structural Genomics Consortium (SGC) website.BAY-369 is the negative control for the active probe, BAY-598. To request a sample of the negative control from the SGC, click here.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
storage
Store at -20°C
BAY-598(S-isomer) Preparation Products And Raw materials
Raw materials
Preparation Products
BAY-598(S-isomer) Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58