2-(trifluoromethoxy)nicotinic acid

Product Name: 2-(trifluoromethoxy)nicotinic acid
CAS No.: 1221171-92-1
Chemical Name: 2-(trifluoromethoxy)nicotinic acid
Synonyms: 2-(trifluoromethoxy)nicotinic acid;3-Pyridinecarboxylic acid, 2-(trifluoromethoxy)-
CBNumber: CB73365473
Molecular Formula: C7H4F3NO3
Formula Weight: 207.11
MOL File: 1221171-92-1.mol

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2-(trifluoromethoxy)nicotinic acid Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 6863CY
Product name: 2-(Trifluoromethoxy)nicotinicacid
Packaging: 1g
Price: $600
Updated: 2021/12/16

AK Scientific

Product number: 6863CY
Product name: 2-(Trifluoromethoxy)nicotinicacid
Packaging: 5g
Price: $1712
Updated: 2021/12/16

Chemenu

Product number: CM248305
Product name: 2-(Trifluoromethoxy)pyridine-3-carboxylicacid
Purity: 95%
Packaging: 1g
Price: $1356
Updated: 2021/12/16

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2-(trifluoromethoxy)nicotinic acid Chemical Properties,Usage,Production

Synthesis

1221171-91-0

1221171-92-1

General procedure for the synthesis of 2-(trifluoromethoxy)pyridine-3-carboxylic acid from 6-chloro-2-(trifluoromethoxy)nicotinic acid: palladium catalyst (10% loaded on charcoal, 450 mg) was added to a solution of 6-chloro-2-(trifluoromethoxy)nicotinic acid (37,1.5 g, 6.2 mmol) and ammonium formate (790 mg, 12.4 mmol, 2.0 equivalent) in a solution of methanol (10 mL). The reaction mixture was stirred at 55 °C for 16 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated by rotary evaporation. The residue was extracted by partitioning between ethyl acetate (2 x 20 mL) and 2.0 M hydrochloric acid (30 mL). The organic layers were combined, dried over anhydrous sodium sulfate, filtered and the solvent evaporated to give pure 2-(trifluoromethoxy)pyridine-3-carboxylic acid (38,1.05 g, 5.0 mmol, 81% yield) as a white powder with a melting point of 82-85 °C. The product was structurally confirmed by 1H NMR (CD3OD, 300 MHz), 19F NMR ((CD3)2CO, 282 MHz) and 13C NMR (CD3OD, 75 MHz), and elemental analysis was performed (C7H4F3NO3, calculated value: C 40.59%, H 1.95%, N 6.76%; measured value: C 40.35%, H 2.03%, N 6.65%) to verify the purity.

References

[1] European Journal of Organic Chemistry, 2010, # 31, p. 6043 - 6066
[2] Patent: WO2010/40461, 2010, A1. Location in patent: Page/Page column 42

2-(trifluoromethoxy)nicotinic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(trifluoromethoxy)nicotinic acid Suppliers

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1221171-92-1, 2-(trifluoromethoxy)nicotinic acidRelated Search:

2-(trifluoromethoxy)nicotinic acid

3-Pyridinecarboxylic acid, 2-(trifluoromethoxy)-

1221171-92-1