ChemicalBook > CAS DataBase List > Ningetinib
Ningetinib
- Product Name
- Ningetinib
- CAS No.
- 1394820-69-9
- Chemical Name
- Ningetinib
- Synonyms
- CS-2653;CT053PTSA;Ningetinib;Ningetinib(free base);Ningetinib, 10 mM in DMSO;Ningetinib-Tosylate(free base);Vascular endothelial growth factor receptor,inhibit,c-Met/HGFR,TAM Receptor,Mer,Tyro3,VEGFR,Ningetinib,Axl,Inhibitor;N-(3-fluoro-4-((7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide;1H-Pyrazole-4-carboxamide, N-[3-fluoro-4-[[7-(2-hydroxy-2-methylpropoxy)-4-quinolinyl]oxy]phenyl]-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-
- CBNumber
- CB73367255
- Molecular Formula
- C31H29FN4O5
- Formula Weight
- 556.58
- MOL File
- 1394820-69-9.mol
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Ningetinib Property
- Density
- 1.348±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 15 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml; DMSO: 2 mg/ml
- form
- A crystalline solid
- pka
- 11.00±0.70(Predicted)
- color
- White to off-white
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 25233
- Product name
- Ningetinib
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $48
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 25233
- Product name
- Ningetinib
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $186
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 25233
- Product name
- Ningetinib
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $301
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 25233
- Product name
- Ningetinib
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $521
- Updated
- 2024/03/01
Biosynth Carbosynth
- Product number
- BN168497
- Product name
- Ningetinib
- Packaging
- 50mg
- Price
- $750
- Updated
- 2021/12/16
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Ningetinib Chemical Properties,Usage,Production
Uses
Ningetinib, is a potent, orally bioavailable small molecule tyrosine kinase inhibitor (TKI) with IC50s of 6.7, 1.9 and <1.0 nM for c-Met, VEGFR2 and Axl, respectively.
in vivo
When single dosed orally (3 mg/kg) to U87MG tumor-bearing nude mice, Ningetinib (CT053PTSA) potently inhibits the phosphorylation of c-Met and its downstream signaling kinases AKT and ERK1/2 for up to 6 hours in tumor tissues. In orthotopic U87MG human glioblastoma xenograft model, Ningetinib prolongs the median survival time (MST) and yields significant increase in life-span value (ILS=32%, p=0.003) at an oral dose of 20 mg/kg/day (dosed 21 days) versus the vehicle-treated group[1].
IC 50
VEGFR2: 1.9 nM (IC50); Axl
Ningetinib Preparation Products And Raw materials
Raw materials
Preparation Products
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Ningetinib Suppliers
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- 0510-83588313-811 18800520310
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- China
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- Fax
- +86-21-52996696
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- 021-61312847; 18021002903
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- QQ:3008007432
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- China
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- 021-31433387 15618786686
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- Tel
- Fax
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