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diphenylterazine

Product Name: diphenylterazine
CAS No.: 344940-63-2
Chemical Name: diphenylterazine
Synonyms: DTZ;diphenylterazine;Diphenylterazine (DTZ);Inhibitor,Diphenylterazine,inhibit;2-Benzyl-6,8-diphenylimidazo[1,2-a]pyrazin-3(7H)-one;Imidazo[1,2-a]pyrazin-3(7H)-one, 6,8-diphenyl-2-(phenylmethyl)-
CBNumber: CB73368328
Molecular Formula: C25H19N3O
Formula Weight: 377.44
MOL File: 344940-63-2.mol

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diphenylterazine Property

Boiling point:: 538.4±60.0 °C(Predicted)
Density: 1.21±0.1 g/cm3(Predicted)
solubility: DMSO:75.0(Max Conc. mg/mL);198.71(Max Conc. mM)
DMF:11.11(Max Conc. mg/mL);29.44(Max Conc. mM)
form: A solid
pka: 6.33±0.40(Predicted)
color: Orange to reddish brown
InChI: InChI=1S/C25H19N3O/c29-25-21(16-18-10-4-1-5-11-18)27-24-23(20-14-8-3-9-15-20)26-22(17-28(24)25)19-12-6-2-7-13-19/h1-15,17,26H,16H2
InChIKey: HYQVAZNNCBIZSK-UHFFFAOYSA-N
SMILES: C12N=C(CC3=CC=CC=C3)C(=O)N1C=C(C1=CC=CC=C1)NC=2C1=CC=CC=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0040304
Product name: Diphenylterazine
Purity: 98.06%
Packaging: 1mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0040304
Product name: Diphenylterazine
Purity: 98.06%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0040304
Product name: Diphenylterazine
Purity: 98.06%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0040304
Product name: Diphenylterazine
Purity: 98.06%
Packaging: 50mg
Price: $1150
Updated: 2021/12/16

DC Chemicals

Product number: 025866
Product name: Diphenylterazine(DTZ)
Packaging: 003
Price: $2400
Updated: 2021/12/16

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diphenylterazine Chemical Properties,Usage,Production

Uses

Diphenylterazine (DTZ) is a bioluminescence agent. Diphenylterazine alone yielded very little background, leading to excellent signal-to-background ratios[1].

in vivo

Diphenylterazine injections into untransfected BALB/c mice do not yield any background emission. The bioluminescence resulting from intraperitoneally injected Diphenylterazine displays extended kinetics^[1].
DTZ (0.3 μmol/mouse (1.13 mg.ml^-1/100 ul/mouse); i.v.) treatment can track tumor growth in a xenograft NU/J mouse model^[4].

References

[1] Yeh HW, et al. Red-shifted luciferase-luciferin pairs for enhanced bioluminescence imaging. Nat Methods. 2017 Oct;14(10):971-974. DOI:10.1038/nmeth.4400
[2] Yeh AH, et al. De novo design of luciferases using deep learning. Nature. 2023 Feb;614(7949):774-780. DOI:10.1038/s41586-023-05696-3
[3] Practical Notes for teLuc-DTZ and Antares2-DTZ (updated 07/29/2019).
[4] Hsien-Wei Yeh, et al. ATP-Independent Bioluminescent Reporter Variants To Improve in Vivo Imaging. ACS Chem Biol. 2019 May 17;14(5):959-965. DOI:10.1021/acschembio.9b00150

diphenylterazine Preparation Products And Raw materials

Raw materials

Preparation Products

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344940-63-2, diphenylterazineRelated Search:

diphenylterazine

DTZ

Imidazo[1,2-a]pyrazin-3(7H)-one, 6,8-diphenyl-2-(phenylmethyl)-

Diphenylterazine (DTZ)

2-Benzyl-6,8-diphenylimidazo[1,2-a]pyrazin-3(7H)-one

Inhibitor,Diphenylterazine,inhibit

344940-63-2