DORA-22

Product Name: DORA-22
CAS No.: 1088991-95-0
Chemical Name: DORA-22
Synonyms: DORA-22;DORA 22,DORA22;DORA-22, 10 mM in DMSO;[(2R,5R)-5-[(5-FLUOROPYRIDIN-2-YL)OXYMETHYL]-2-METHYLPIPERIDIN-1-YL]-(5-FLUORO-2-PYRIMIDIN-2-YLPHENYL)METHANONE;Methanone, [(2R,5R)-5-[[(5-fluoro-2-pyridinyl)oxy]methyl]-2-methyl-1-piperidinyl][5-fluoro-2-(2-pyrimidinyl)phenyl]-
CBNumber: CB73369734
Molecular Formula: C23H22F2N4O2
Formula Weight: 424.44
MOL File: 1088991-95-0.mol

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DORA-22 Property

Boiling point:: 524.3±50.0 °C(Predicted)
Density: 1.258±0.06 g/cm3(Predicted)
pka: 1.54±0.22(Predicted)

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Hazard and Precautionary Statements (GHS)

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DORA-22 Chemical Properties,Usage,Production

Description

DORA-22 is an orexin receptor antagonist.

Uses

DORA-22 is an orally active dual orexinergic receptor antagonist, and improves the sleep disruption and memory impairment. DORA-22 can be used for study of insomnia[1][2].

References

[1] Gamble MC, et al. The dual orexinergic receptor antagonist DORA-22 improves the sleep disruption and memory impairment produced by a rodent insomnia model. Sleep. 2020;43(3):zsz241. DOI:10.1093/sleep/zsz241
[2] Lin Y, Ret al. Positive allosteric adenosine A2A receptor modulation suppresses insomnia associated with mania- and schizophrenia-like behaviors in mice. Front Pharmacol. 2023;14:1138666. Published 2023 Apr 19. DOI:10.3389/fphar.2023.1138666

DORA-22 Preparation Products And Raw materials

Raw materials

Preparation Products

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DORA-22 Suppliers

China 16 United States 2 Global 18

Nanjing Norris-Pharm Technology Co., Ltd

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Nanjing Norris-Pharm Technology Co., Ltd

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1088991-95-0, DORA-22Related Search:

DORA-22

[(2R,5R)-5-[(5-FLUOROPYRIDIN-2-YL)OXYMETHYL]-2-METHYLPIPERIDIN-1-YL]-(5-FLUORO-2-PYRIMIDIN-2-YLPHENYL)METHANONE

DORA 22,DORA22

Methanone, [(2R,5R)-5-[[(5-fluoro-2-pyridinyl)oxy]methyl]-2-methyl-1-piperidinyl][5-fluoro-2-(2-pyrimidinyl)phenyl]-

DORA-22, 10 mM in DMSO

1088991-95-0