ChemicalBook > CAS DataBase List > DORA-22
DORA-22
- Product Name
- DORA-22
- CAS No.
- 1088991-95-0
- Chemical Name
- DORA-22
- Synonyms
- DORA-22;DORA 22,DORA22;DORA-22, 10 mM in DMSO;[(2R,5R)-5-[(5-FLUOROPYRIDIN-2-YL)OXYMETHYL]-2-METHYLPIPERIDIN-1-YL]-(5-FLUORO-2-PYRIMIDIN-2-YLPHENYL)METHANONE;Methanone, [(2R,5R)-5-[[(5-fluoro-2-pyridinyl)oxy]methyl]-2-methyl-1-piperidinyl][5-fluoro-2-(2-pyrimidinyl)phenyl]-
- CBNumber
- CB73369734
- Molecular Formula
- C23H22F2N4O2
- Formula Weight
- 424.44
- MOL File
- 1088991-95-0.mol
More
Less
DORA-22 Property
- Boiling point:
- 524.3±50.0 °C(Predicted)
- Density
- 1.258±0.06 g/cm3(Predicted)
- pka
- 1.54±0.22(Predicted)
More
Less
DORA-22 Chemical Properties,Usage,Production
Description
DORA-22 is an orexin receptor antagonist.
Uses
DORA-22 is an orally active dual orexinergic receptor antagonist, and improves the sleep disruption and memory impairment. DORA-22 can be used for study of insomnia[1][2].
References
[1] Gamble MC, et al. The dual orexinergic receptor antagonist DORA-22 improves the sleep disruption and memory impairment produced by a rodent insomnia model. Sleep. 2020;43(3):zsz241. DOI:10.1093/sleep/zsz241
[2] Lin Y, Ret al. Positive allosteric adenosine A2A receptor modulation suppresses insomnia associated with mania- and schizophrenia-like behaviors in mice. Front Pharmacol. 2023;14:1138666. Published 2023 Apr 19. DOI:10.3389/fphar.2023.1138666
DORA-22 Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
DORA-22 Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- +1-781-999-5354;
- support@targetmol.com
- Country
- United States
- ProdList
- 39035
- Advantage
- 58