N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide
- Product Name
- N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide
- CAS No.
- 1362151-42-5
- Chemical Name
- N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide
- Synonyms
- GNE-618;GNE618,GNE 618;N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide;1H-Pyrazolo[3,4-b]pyridine-5-carboxamide, N-[[4-[[3-(trifluoromethyl)phenyl]sulfonyl]phenyl]methyl]-
- CBNumber
- CB73373023
- Molecular Formula
- C21H15F3N4O3S
- Formula Weight
- 460.4290096
- MOL File
- 1362151-42-5.mol
N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide Property
- Boiling point:
- 740.6±60.0 °C(Predicted)
- Density
- 1.479±0.06 g/cm3(Predicted)
- solubility
- DMSO: Soluble
- form
- Solid
- pka
- 8.97±0.40(Predicted)
- color
- Off-white to light yellow
N-Bromosuccinimide Price
- Product number
- CS-0012107
- Product name
- GNE-618
- Purity
- 98.14%
- Packaging
- 5mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- CS-0012107
- Product name
- GNE-618
- Purity
- 98.14%
- Packaging
- 10mg
- Price
- $330
- Updated
- 2021/12/16
- Product number
- CS-0012107
- Product name
- GNE-618
- Purity
- 98.14%
- Packaging
- 25mg
- Price
- $660
- Updated
- 2021/12/16
- Product number
- CS-0012107
- Product name
- GNE-618
- Purity
- 98.14%
- Packaging
- 50mg
- Price
- $1000
- Updated
- 2021/12/16
- Product number
- CS-0012107
- Product name
- GNE-618
- Purity
- 98.14%
- Packaging
- 100mg
- Price
- $1500
- Updated
- 2021/12/16
N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide Chemical Properties,Usage,Production
Description
GNE-618 is an inhibitor of nicotinamide phosphoribosyl transferase (NAMPT).
Uses
GNE-618 is a potent, orally active nicotinamide phosphoribosyl transferase (NAMPT) inhibitor with an IC50 of 6 nM. GNE-618 depletes NAD levels and induces tumor cell death. Anti-tumor activity[1].
in vivo
GNE-618 (100 mg/kg; p.o.; twice daily for 5 days) significantly inhibits tumor growth by 88% and has minimal effects on body weight in STO#81 patient-derived gastric model[1].
References
[1] Xiao Y, et al. Dependence of tumor cell lines and patient-derived tumors on the NAD salvage pathway rendersthem sensitive to NAMPT inhibition with GNE-618. Neoplasia. 2013 Oct;15(10):1151-60. DOI:10.1593/neo.131304
[2] XIAOZHANG ZHENG . Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)[J]. Bioorganic & Medicinal Chemistry Letters, 2013, 23 20: Pages 5488-5497. DOI: 10.1016/j.bmcl.2013.08.074
N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 19962
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 52923
- Advantage
- 58