(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol
- Product Name
- (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol
- CAS No.
- 2040291-27-6
- Chemical Name
- (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol
- Synonyms
- LM-5179;LLY-283;LLY-283 (LLY283);LLY-283 >=98% (HPLC);7-[(5R)-5-CPhenyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine;7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[(5R)-5-C-phenyl-β-D-ribofuranosyl]-;(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol
- CBNumber
- CB73373902
- Molecular Formula
- C17H18N4O4
- Formula Weight
- 342.35
- MOL File
- 2040291-27-6.mol
(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol Property
- Boiling point:
- 688.9±55.0 °C(Predicted)
- Density
- 1?+-.0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 60 mg/ml; Ethanol: 60 mg/ml
- form
- A crystalline solid
- pka
- 12.46±0.70(Predicted)
N-Bromosuccinimide Price
- Product number
- 21596
- Product name
- LLY-283
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 21596
- Product name
- LLY-283
- Packaging
- 25mg
- Price
- $456
- Updated
- 2024/03/01
- Product number
- 21596
- Product name
- LLY-283
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 21596
- Product name
- LLY-283
- Packaging
- 10mg
- Price
- $243
- Updated
- 2024/03/01
- Product number
- BL166665
- Product name
- LLY 283
- Packaging
- 100mg
- Price
- $1950
- Updated
- 2021/12/16
(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol Chemical Properties,Usage,Production
Description
LLY-283 is an inhibitor of protein arginine methyltransferase 5 (PRMT5; IC50 = 22 nM). It is selective for PRMT5 over a panel of methyltransferases, including PRMT4, -6, and -7 at 1 μM. It reduces symmetric demethylation of SmBB'' in MCF-7 cells (IC50 = 25 nM) and inhibits proliferation of various breast, gastric, hematological, lung, skin, and ovarian cancer cell lines (IC50s = 3-30 nM). LLY-283 (20 mg/kg) inhibits tumor growth in an A375 mouse xenograft model. It also disrupts alternative splicing events in, and inhibits proliferation and self-renewal of, patient-derived glioblastoma stem cells and increases survival in an orthotopic patient-derived xenograft (PDX) mouse model. See the Structural Genomics Consortium (SGC) website for more information.
(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5[(R)-hydroxy(phenyl)methyl]tetrahydrofuran-3,4-diol Preparation Products And Raw materials
Raw materials
Preparation Products
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