ChemicalBook > CAS DataBase List > Aftin-4

Aftin-4

Product Name
Aftin-4
CAS No.
866893-90-5
Chemical Name
Aftin-4
Synonyms
Aftin-4;Aftin-4 >=98% (HPLC);AFTIN-4;AFTIN 4;AFTIN4;Aftin-4, 10 mM in DMSO;N6-methyl-(R)-roscovitine;β-amyloid peptide,inhibit,Abeta,Amyloid-β,Aftin-4,Inhibitor;(R)-2-((6-(Benzyl(methyl)amino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol;1-Butanol, 2-[[9-(1-methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2R)-
CBNumber
CB73381022
Molecular Formula
C20H28N6O
Formula Weight
368.48
MOL File
866893-90-5.mol
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Aftin-4 Property

storage temp. 
-20°C
solubility 
DMSO: soluble
form 
powder
color 
white to beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1578
Product name
Aftin-4
Purity
≥98% (HPLC)
Packaging
5MG
Price
$214
Updated
2023/06/20
Sigma-Aldrich
Product number
SML1578
Product name
Aftin-4
Purity
≥98% (HPLC)
Packaging
25MG
Price
$639
Updated
2023/06/20
Cayman Chemical
Product number
27341
Product name
Aftin-4
Packaging
1mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
27341
Product name
Aftin-4
Packaging
25mg
Price
$593
Updated
2024/03/01
Cayman Chemical
Product number
27341
Product name
Aftin-4
Packaging
5mg
Price
$202
Updated
2024/03/01
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Aftin-4 Chemical Properties,Usage,Production

Description

Aftin-4 is an inducer of amyloid-β (1-42) (Aβ42). It selectively increases extracellular Aβ42 over Aβ40 production in N2a-AβPP695 cells when used at concentrations ranging from 1 to 100 mM. In vivo, aftin-4 (3-20 nmol/animal, i.c.v.) increases hippocampal Aβ42 content, lipid peroxidation, and production of the pro-inflammatory cytokines IL-1β, IL-6, and TNF-α in mice. It also induces spatial working and spatial reference memory deficits in mice, effects that are reversed by co-administration of the γ-secretase inhibitor BMS-299,897.

Uses

Aftin 4, is an Amyloid-β42 (Aβ42) inducer, that increases Aβ1-42 levels in vivo in mice and provokes rapidly a sustained toxicity highly reminiscent of Alzheimer’s disease (AD).

Biochem/physiol Actions

Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 can thus be used to induce a rapid, acute Alzheimer′s disease-like toxicity in the rodent brain.

storage

+4°C

Aftin-4 Preparation Products And Raw materials

Raw materials

Preparation Products

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866893-90-5, Aftin-4Related Search:


  • Aftin-4
  • AFTIN-4;AFTIN 4;AFTIN4
  • N6-methyl-(R)-roscovitine
  • 1-Butanol, 2-[[9-(1-methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2R)-
  • Aftin-4 >=98% (HPLC)
  • (R)-2-((6-(Benzyl(methyl)amino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol
  • β-amyloid peptide,inhibit,Abeta,Amyloid-β,Aftin-4,Inhibitor
  • Aftin-4, 10 mM in DMSO
  • 866893-90-5
  • 66893-90-5
  • C20H28N6O