DLin-MC3-DMA

Product Name: DLin-MC3-DMA
CAS No.: 1224606-06-7
Chemical Name: DLin-MC3-DMA
Synonyms: D-Lin-MC3-DMA (MC3);RV28;RV 28;RV-28;DLin-M-C3-DMA;Metalaxyl Impurity 1 (Metalaxyl-M);dilinoleylmethyl 4-(dimethylamino)butanoate;D-LIN-MC3-DMA;DLINMC3DMA;D-LIN-MC-3-DMA;D-LIN-MC3-DMA;Heptatriaconta-6,9,28,31-tetraen-19-yl-4-(dimethylamino)butanoate;O-(Z,Z,Z,Z-heptatriaconta-6,9,26,29-tetraen-19-yl)-4-(N,N-dimethylamino)
CBNumber: CB73382342
Molecular Formula: C43H79NO2
Formula Weight: 642.09
MOL File: 1224606-06-7.mol

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DLin-MC3-DMA Property

Boiling point:: 670.2±43.0 °C(Predicted)
Density: 0.886±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in Ethanol, DMSO, DMF
pka: 9.37±0.28(Predicted)
form: Liquid
color: Colorless to light yellow
InChIKey: NRLNQCOGCKAESA-KWXKLSQISA-N
SMILES: C(OC(CCCCCCCC/C=C\C/C=C\CCCCC)CCCCCCCC/C=C\C/C=C\CCCCC)(=O)CCCN(C)C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-25497
Product name: D-Lin-MC3-DMA
Purity: 98%
Packaging: 50mg
Price: $450
Updated: 2021/12/16

BroadPharm

Product number: BP-25497
Product name: D-Lin-MC3-DMA
Purity: 98%
Packaging: 100mg
Price: $780
Updated: 2021/12/16

DC Chemicals

Product number: DC10800
Product name: DLin-MC3-DMA
Purity: >98%
Packaging: 250mg
Price: $1300
Updated: 2021/12/16

Ambeed

Product number: A746322
Product name: (6Z,9Z,28Z,31Z)-Heptatriaconta-6,9,28,31-tetraen-19-yl4-(dimethylamino)butanoate
Purity: 98%
Packaging: 1g
Price: $1945
Updated: 2021/12/16

Ambeed

Product number: A746322
Product name: (6Z,9Z,28Z,31Z)-Heptatriaconta-6,9,28,31-tetraen-19-yl4-(dimethylamino)butanoate
Purity: 98%
Packaging: 250mg
Price: $572
Updated: 2021/12/16

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DLin-MC3-DMA Chemical Properties,Usage,Production

Description

D-Lin-MC3-DMA (MC3, DLin-MC3-DMA) is a potent and ionizable cationic lipid. D-Lin-MC3-DMA is used for delivery of siRNA in vivo. DLin-MC3-DMA, or (6Z,9Z,28Z,31Z)-heptatriacont-6,9,28,31-tetraene-19-yl 4-(dimethylamino)butanoate , is one of the most utilized cationic lipids that is used for making Lipid Nano-Particles (LNPs). These lipids, can form nanoparticles that can encapsulate and deliver siRNA, mRNA, DNA or small molecules into the cytoplasm and represent the most advanced delivery platforms for systemic administration of active molecules.

Uses

DLin-M-C3-DMA is a commonly used drug delivery vehicle for the fabrication of lipid nanoparticles (LNPs), which exert therapeutic effects by encapsulating and delivering siRNA, mRNA, DNA, or small molecules into the cytoplasm of the cell, and is a potent siRNA delivery vehicle.

Definition

(6Z,9Z,28Z,31Z)-heptatriacont-6,9,28,31-tetraene-19-yl 4-(dimethylamino)butanoate (DLin-MC3-DMA or MC3, liquid oil) was identified as one of the most promising ionizable lipids due to its high transfection efficiency and is used in the first FDA-approved drug for the treatment of amyloidosis. In 2020, Ermilova et al. derived parameters for MC3 in combination with the Slipids force field. Unfortunately, the authors did not parametrize the protonated state of the MC3 molecule. Since MC3 has an apparent pKa of about 6.44, the protonated state plays an essential role: it ensures efficient encapsulation of the nucleic acids at low pH and a high charge at endosomal pH, enabling the drug release from the LNP. At physiological pH, the MC3 lipids are neutral, enabling the circulation of largely uncharged LNPs. For the modelling, it is beneficial to parametrize both states simultaneously[1].

Application

DLin-MC3-DMA is an ionizable cationic lipid (apparent pKa = 6.44) that has been used in the generation of lipid nanoparticles (LNPs) encapsulating siRNA, mRNA, or plasmid DNA for use in vitro and in vivo. LNPs containing DLin-MC3-DMA accumulate in the muscle and non-draining lymph nodes after intramuscular administration and in the spleen after intravenous administration in mice. DLin-MC3-DMA-containing LNPs encapsulating siRNA targeting F7, the gene encoding Factor VII, reduce hepatic and plasma Factor VII levels in mice without increasing serum levels of alanine transaminase (ALT), aspartate aminotransferase (AST), or bile acids, which are all markers of liver toxicity. Formulations containing DLin-MC3-DMA have been used in LNPs encapsulating transthyretin-directed siRNA to treat hereditary transthyretin-mediated amyloidosis-induced polyneuropathy.

Biological Activity

DLin-MC3-DMA is an ionizable lipid used in combination with other lipids for encapsulation of RNA and DNA into lipid nanoparticles (LNPs). Administration of DLin-MC3-DMA based LNPs have delivered siRNA and reduced Factor VII levels in mice. Delivery of BCR-ABL siRNA reduced leukemic burden in a mouse model of chronic myeloid leukemia (CML).

storage

Store at -20°C

References

[1] Mohd Ibrahim. “Structural Insights on Ionizable Dlin-MC3-DMA Lipids in DOPC Layers by Combining Accurate Atomistic Force Fields, Molecular Dynamics Simulations and Neutron Reflectivity.” bioRxiv?: the preprint server for biology 56 1 (2023).

DLin-MC3-DMA Preparation Products And Raw materials

Raw materials

Preparation Products

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DLin-MC3-DMA Suppliers

China 142 United States 8 Global 150

TargetMol Chemicals Inc.

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Aladdin Scientific

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TargetMol Chemicals Inc.

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View Lastest Price from DLin-MC3-DMA manufacturers

XIAMEN SINOPEG BIOTECH CO., LTD.

Product: D-Lin-MC3-DMA 1224606-06-7
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 1g/bottle , 10g/bottle, 100g/bottle
Release date: 2024-11-25

Hebei Mojin Biotechnology Co., Ltd

Product: D-Lin-MC3-DMA 1224606-06-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-28

Career Henan Chemical Co

Product: DLin-M-C3-DMA 1224606-06-7
Price: US $1.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 200kg
Release date: 2019-12-23

1224606-06-7, DLin-MC3-DMARelated Search:

M2 2-Amino-4-chloro-6-methylpyrimidine H-AP53 Primer (2 &micro

DLin-M-C3-DMA

D-LIN-MC3-DMA;DLINMC3DMA;D-LIN-MC-3-DMA;D-LIN-MC3-DMA

(6Z,9Z,28Z,31Z)-heptatriacont-6,9,28,31-tetraene-19-yl 4-(dimethylamino)butanoate

(6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate

Butanoic acid, 4-(dimethylamino)-, (10Z,13Z)-1-(9Z,12Z)-9,12-octadecadien-1-yl-10,13-nonadecadien-1-yl ester

O-(Z,Z,Z,Z-heptatriaconta-6,9,26,29-tetraen-19-yl)-4-(N,N-dimethylamino)

D-Lin-MC3-DMA (MC3)

dilinoleylmethyl 4-(dimethylamino)butanoate

Heptatriaconta-6,9,28,31-tetraen-19-yl-4-(dimethylamino)butanoate

4-(dimethylamino)-butanoic acid, (10Z,13Z)-1-(9Z,12Z)-9,12-octadecadien-1-yl-10,13-nonadecadien-1-yl ester

RV 28

RV28

RV-28

Metalaxyl Impurity 1 (Metalaxyl-M)

1224606-06-7

224606-06-7

C43H79NO2

Intermediates