ChemicalBook > CAS DataBase List > SR 57227 HYDROCHLORIDE

SR 57227 HYDROCHLORIDE

Product Name
SR 57227 HYDROCHLORIDE
CAS No.
77145-61-0
Chemical Name
SR 57227 HYDROCHLORIDE
Synonyms
cm57227;sr57227a;CM-57277;SR57227HCl;SR 57227 HYDROCHLORIDE;SR 57227A HYDROCHLORIDE;SR 57227A, 10 mM in DMSO;4-AMINO-1-(6-CHLORO-2-PYRIDYL)-PIPERIDINE HYDROCHLORIDE;1-(6-CHLORO-2-PYRIDINYL)-4-PIPERIDINAMINE HYDROCHLORIDE;1-(6-chloropyridin-2-yl)piperidin-4-amine hydrochloride
CBNumber
CB7365504
Molecular Formula
C10H15Cl2N3
Formula Weight
248.15
MOL File
77145-61-0.mol
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SR 57227 HYDROCHLORIDE Property

storage temp. 
Store at RT
solubility 
H2O: 9 mg/mL, soluble
form 
solid
color 
white
Water Solubility 
H2O: soluble 9mg/mL
InChI
1S/C10H14ClN3.ClH/c11-9-2-1-3-10(13-9)14-6-4-8(12)5-7-14;/h1-3,8H,4-7,12H2;1H
InChIKey
FUMINTAAUJUVMP-UHFFFAOYSA-N
SMILES
Cl.NC1CCN(CC1)c2cccc(Cl)n2
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Safety

Hazard Codes 
T
Risk Statements 
25-36/37/38
Safety Statements 
26-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
TM3465250
Storage Class
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications
Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S1688
Product name
SR 57227A
Purity
solid
Packaging
5mg
Price
$206
Updated
2025/07/31
Tocris
Product number
1205
Product name
SR57227hydrochloride
Purity
≥99%(HPLC)
Packaging
10
Price
$151
Updated
2021/12/16
Tocris
Product number
1205
Product name
SR57227hydrochloride
Purity
≥99%(HPLC)
Packaging
50
Price
$568
Updated
2021/12/16
Usbiological
Product number
256749
Product name
SR 57227 hydrochloride
Packaging
10mg
Price
$389
Updated
2021/12/16
TRC
Product number
S684440
Product name
SR57227AHydrochloride
Packaging
10mg
Price
$425
Updated
2021/12/16
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SR 57227 HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

SR 57227A acts as highly potent and shows high affinity for the 5-HT3 receptor agonist.

Biological Activity

A high affinity, selective 5-HT 3 receptor agonist, active in vivo and CNS penetrant.

in vivo

SR 57227A (1-30 mg/kg; i.p.) dose-dependently reduces immobility time in the forced swimming test with an ED50 value for this effect of 14.2 mg/kg[2].
In the forced swimming test, SR 57227A dose-dependently reduces the duration of immobility in rats after i.p. administration. (ED50=7.6 mg/kg i.p. in rats.) SR 57227A is also active in both species after oral administration. In a time-course study in mice, SR 57227A (20 mg/kg p.o.) produces a significant effect lasting 6 hours. SR 57227A (1 and 3 mg/kg i.p.) reduces the elevation of the escape failures in the learned helplessness model in rats by 50-60% on the last two days of the avoidance task, and reduces isolation-induced aggressivity in mice by 50 to 85%, an effect which is antagonised by Zacopride (1 mg/kg i.p.)[2].

storage

Store at RT

SR 57227 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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SR 57227 HYDROCHLORIDE Suppliers

China 35 Germany 2 Japan 1 Switzerland 1 United Kingdom 2 United States 8 Global 49
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
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3bsc@sina.com
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China
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EMMX Biotechnology LLC
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888-539-0666
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888-539-0666
Email
info@emmx.com
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United States
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
Fax
021-65675885
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info@efebio.com
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China
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
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China
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71826
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Tianjin Kailiqi Biotechnology Co., Ltd.
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15076683720
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022-23754520
Email
klq@cw-bio.com
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China
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Shanghai Han-Xiang Chemical Co., Ltd.
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15971444841
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18327183813
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amber@biochempartner.com
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China
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ROSEWA HOLDING GROUP CO.,LIMITED
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+86-023-62871537
Email
sales@rosewachem.com
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China
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
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United States
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32470
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Energy Chemical
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021-58432009 400-005-6266
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021-58436166
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marketing@energy-chemical.com
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China
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Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 15801484223;
Email
psaitong@jm-bio.com
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China
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29757
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58

77145-61-0, SR 57227 HYDROCHLORIDERelated Search:

SR 57227 HYDROCHLORIDE

  • sr57227a
  • 1-(6-CHLORO-2-PYRIDINYL)-4-PIPERIDINAMINE HYDROCHLORIDE
  • 4-AMINO-1-(6-CHLORO-2-PYRIDYL)-PIPERIDINE HYDROCHLORIDE
  • SR 57227A HYDROCHLORIDE
  • SR 57227 HYDROCHLORIDE
  • SR57227HCl
  • CM-57277
  • 1-(6-chloropyridin-2-yl)piperidin-4-amine hydrochloride
  • 1-(6-chloro-2-pyridinyl)-4-piperidinaminemonohydrochloride
  • 1-(6-chloro-2-pyridinyl)-4-piperidinaminmonohydrochloride
  • 4-amino-1-(6-chloro-2-pyridyl)piperidinemonohydrochloride
  • cm57227
  • immobility,barrier,SR 57227A,Serotonin Receptor,cell,brain,5-HT Receptor,Inhibitor,5-hydroxytryptamine Receptor,anti-depressant,inhibit,blood,NG 108-15
  • SR 57227A, 10 mM in DMSO
  • 77145-61-0
  • C10H14ClN3HCl
  • C10H15Cl2N3HCl
  • C10H15N3Cl2
  • Serotonin receptor