4-CHLORO-2-BUTANONE

Product Name: 4-CHLORO-2-BUTANONE
CAS No.: 6322-49-2
Chemical Name: 4-CHLORO-2-BUTANONE
Synonyms: 4-chlorobutan-2-one;Einecs 228-680-6;TIMTEC-BB SBB007824;1-CHLORO-3-BUTANONE;4-CHLORO-2-BUTANONE;2-Butanone, 4-chloro-;2-Chloroethylmethylketone;4-Chloro-2-butanone, Pract.;B-CHLOROETHYL METHYL KETONE;TIANFUCHEM--6322-49-2--4-CHLORO-2-BUTANONE factory price
CBNumber: CB7370931
Molecular Formula: C4H7ClO
Formula Weight: 106.55
MOL File: 6322-49-2.mol

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4-CHLORO-2-BUTANONE Property

Boiling point:: 146℃
Density: 1.033
refractive index: 1.4299-1.4334
Flash point:: 45℃
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Chloroform, Ethyl Acetate (Slightly)
form: Oil
color: Black
InChI: InChI=1S/C4H7ClO/c1-4(6)2-3-5/h2-3H2,1H3
InChIKey: MAGOYBJJLVSJIC-UHFFFAOYSA-N
SMILES: CC(=O)CCCl
LogP: 0.666 (est)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: C292860
Product name: 4-Chloro-2-butanone
Packaging: 10g
Price: $215
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC163202
Product name: 4-Chloro-2-butanone
Packaging: 5G
Price: $225
Updated: 2021/12/16

ChemScene

Product number: CS-W022162
Product name: 4-Chlorobutan-2-one
Purity: >97.0%
Packaging: 25g
Price: $255
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC163202
Product name: 4-Chloro-2-butanone
Packaging: 10g
Price: $380
Updated: 2021/12/16

Matrix Scientific

Product number: 172014
Product name: 4-Chloro-2-butanone
Packaging: 25g
Price: $450
Updated: 2021/12/16

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4-CHLORO-2-BUTANONE Chemical Properties,Usage,Production

Chemical Properties

Liquid. Boiling point 123°C (98 kPa, decomposition), 55°C (2.13 kPa), relative density 1.068 (23/4°C), refractive index 1.4284 (23°C).

Uses

4-Chloro-2-butanone acts as a reagent for the preparation of pyrrolopyrazine derivatives as selective spleen tyrosine kinase inhibitors.

Application

4-Chloro-2-butanone is a reagent for Robinson annulation; often interchangeable with methyl vinyl ketone and the corresponding Mannich base 4-dialkylamino-2-butanone.

Synthesis Reference(s)

Synthetic Communications, 26, p. 3479, 1996 DOI: 10.1080/00397919608003752

Synthesis

590-90-9

6322-49-2

General procedure for the synthesis of β-chlorobutanone from 4-hydroxy-2-butanone: 4-hydroxy-2-butanone (0.881 g, 10 mmol), dichloromethane (2 ml), and thionyl chloride (1.46 ml, 20 mmol) were added in a reaction flask and the reaction was stirred at room temperature overnight. Upon completion of the reaction, the solvent was removed by rotary evaporator and the residue was dried with a stream of nitrogen to give 2-chlorobutan-2-one (1.06 g). The product was characterized by 1H-NMR (400 MHz, DMSO-d6): δ 2.12 (s, 3H), 2.94 (t, 2H), 3.74 (t, 2H).

References

[1] Angewandte Chemie - International Edition, 2012, vol. 51, # 27, p. 6713 - 6716
[2] Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1936, vol. 202, p. 1687
[3] Zhurnal Obshchei Khimii, 1938, vol. 8, p. 909
[4] Chem. Zentralbl., 1939, vol. 110, # I, p. 4953
[5] Patent: WO2015/169999, 2015, A1. Location in patent: Page/Page column 63

4-CHLORO-2-BUTANONE Preparation Products And Raw materials

Raw materials

Paraformaldehyde

Preparation Products

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4-CHLORO-2-BUTANONE Suppliers

China 120 Germany 1 India 2 United Kingdom 3 United States 9 Global 135

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View Lastest Price from 4-CHLORO-2-BUTANONE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-CHLORO-2-BUTANONE 6322-49-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-28

Sichuan Zhuoyu Yantang Technology Co., Ltd.

Product: 4-CHLORO-2-BUTANONE 6322-49-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-06-28

Shaanxi Dideu Medichem Co. Ltd

Product: 4-CHLORO-2-BUTANONE 6322-49-2
Price: US $6509.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1T
Release date: 2020-06-28

6322-49-2, 4-CHLORO-2-BUTANONERelated Search:

3-CHLORO-4'-FLUOROPROPIOPHENONE 2,3,4,5,6,6-HEXACHLORO-2,4-CYCLOHEXADIEN-1-ONE 4'-BROMO-3-CHLOROPROPIOPHENONE 3-Chloropropiophenone Tetrachloro-o-benzoquinone B-CHLORO-4-METHYLPROPIOPHENONE ENDRIN KETONE 4-CHLORO-2-BUTANONE 3,4'-Dichloropropiophenone 1-(4-Fluorophenyl)-4-chloro-1-butanone 1-(3,4-Dimethylphenyl)-4-chloro-1-butanone 1-(4-Methoxyphenyl)-4-chloro-1-butanone 1-(4-BROMOPHENYL)-4-CHLORO-1-BUTANONE 3-Chloro-2-butanone 1-(4-Hydroxyphenyl)-4-chloro-1-butanone PENTACHLORO-A-KETOHYDRONAPHTHALENE 1-CHLORO-3-PENTANONE tetrachlorocyclobut-2-enone

B-CHLOROETHYL METHYL KETONE

TIMTEC-BB SBB007824

4-chlorobutan-2-one

4-Chloro-2-butanone, Pract.

Einecs 228-680-6

2-Butanone, 4-chloro-

2-Chloroethylmethylketone

4-CHLORO-2-BUTANONE

1-CHLORO-3-BUTANONE

TIANFUCHEM--6322-49-2--4-CHLORO-2-BUTANONE factory price

6322-49-2

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