DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE

Product Name: DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE
CAS No.: 632-93-9
Chemical Name: DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE
Synonyms: Dicarbethoxydihydrocollidine;1,4-Dihydro-3,5-dicarbethoxycollidine;3,5-dicarbethoxy-1,4-dihydrocollidine;3,5-diethoxycarbonyl-1,4-dihydrocollidine;3,5-dicarbethoxy-1,4-dihydrocollidine, DDC;3,5-Bis(ethoxycarbonyl)-1,4-dihydrocollidine;3,5-DIETHOXYCARBONYL-1,4-DIHYDRO-2,4,6-COLLIDINE;Diethyl 1,4-dihydro-s-collidine-3,5-dicarboxylate;3,5-DICARBETHOXY-1,4-DIHYDRO-2,4,6-TRIMETHYLPYRIDINE;3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine >
CBNumber: CB7373477
Molecular Formula: C14H21NO4
Formula Weight: 267.32
MOL File: 632-93-9.mol

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DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE Property

Melting point:: 130-132 °C(lit.)
Boiling point:: 410.51°C (rough estimate)
Density: 1.1116 (rough estimate)
refractive index: 1.5280 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMF: 30 mg/ml; DMF:PBS (pH 7.2); (1:7): 0.125 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml
pka: 3.53±0.70(Predicted)
form: powder to crystal
color: White to Orange to Green
InChI: InChI=1S/C14H21NO4/c1-6-18-13(16)11-8(3)12(14(17)19-7-2)10(5)15-9(11)4/h8,15H,6-7H2,1-5H3
InChIKey: CDVAIHNNWWJFJW-UHFFFAOYSA-N
SMILES: C1(C)NC(C)=C(C(OCC)=O)C(C)C=1C(OCC)=O
CAS DataBase Reference: 632-93-9(CAS DataBase Reference)
EPA Substance Registry System: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,4,6-trimethyl-, diethyl ester (632-93-9)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
RTECS: US7979375
TSCA: TSCA listed
HS Code: 2933.39.9200
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 137030
Product name: Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate
Purity: 99%
Packaging: 25g
Price: $177
Updated: 2025/07/31

TCI Chemical

Product number: D0558
Product name: 3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine
Purity: >98.0%(GC)
Packaging: 1g
Price: $16
Updated: 2025/07/31

TCI Chemical

Product number: D0558
Product name: 3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine
Purity: >98.0%(GC)
Packaging: 5g
Price: $29
Updated: 2025/07/31

Cayman Chemical

Product number: 23230
Product name: Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate
Purity: ≥98%
Packaging: 10g
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 23230
Product name: Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate
Purity: ≥98%
Packaging: 25g
Price: $77
Updated: 2024/03/01

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DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE Chemical Properties,Usage,Production

Description

Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate (DDC) inhibits heme production by inhibiting ferrochelatase, the enzyme that catalyzes the addition of Fe²⁺ to protoporphyrin IX to create heme B. Chronic DDC administration induces Mallory-Denk body formation, a feature of alcoholic and non-alcoholic hepatitis, and reduces IL-12A methylation in mouse liver.

Chemical Properties

almost white crystalline powder

Uses

Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate was used to induce Mallory-Denk body formation in mice in vivo.

Definition

ChEBI: A dihydropyridine that is 2,4,6-trimethyl-1,4-dihydropyridine substituted by ethoxycarbonyl groups at positions 3 and 5.

Biochem/physiol Actions

Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate blocks the heme synthesis and prevents the induction of hepatic heme oxygenase-1 in mice.

Purification Methods

Crystallise the ester from hot EtOH/water mixture. [Beilstein 22 H 147, 22 I 529, 22 II 100, 22 III/IV 1594.]

References

[1] J. ONISAWA R L. Effects of diethyl-1, 4-dihydro-2, 4,6-trimethylpyridine-3,5-dicarboxylate on the metabolism of porphyrins and iron.[J]. The Journal of Biological Chemistry, 1963, 44 1: 724-727. DOI: 10.1016/s0021-9258(18)81326-6
[2] QX YUAN. Mallory body induction in drug-primed mouse liver[J]. Hepatology, 1996, 24 3: Pages 603-612. DOI: 10.1053/jhep.1996.v24.pm0008781332
[3] J. OLIVA S. W F. Changes in IL12A methylation pattern in livers from mice fed DDC[J]. Experimental and molecular pathology, 2012, 92 2: Pages 191-193. DOI: 10.1016/j.yexmp.2012.01.001

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE Suppliers

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Shandong Libixi Biopharmaceutical Technology Co., Ltd.

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View Lastest Price from DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE 632-93-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-13

Honest Joy Holdings Limited

Product: 3,5-Dicarbethoxy-1,4-dihydro-2,4,6-trimethylpyridine 632-93-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.8%
Supply Ability: 100 tons
Release date: 2022-02-21

632-93-9, DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATERelated Search:

Diethyl pyridine-3,5-dicarboxylate DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE Nimodipine 3,5-Pyridinedicarboxylic acid 2,4,6-Collidine 3,5-PYRIDINEDICARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-4-(3,4,5-TRIMETHOXYPHENYL)-, DIETHYL ESTER 2,6-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3,4,5-TRICARBOXYLIC ACID 3,5-DIETHYL ESTER DIETHYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(4-F& DIETHYL 4-ETHYL-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLATE Diethyl2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate 2,6-Dimethyl-4-(2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester AURORA 3177 LABOTEST-BB LT00261244 AURORA 3480 diethyl 2,6-dimethyl-4-thiophen-2-yl-1,4-dihydropyridine-3,5-dicarboxylate DIETHYL 1,4-DIHYDRO-2,6-DIMETHYL-1,4-DIPHENYL-3,5-PYRIDINEDICARBOXYLATE AURORA 4028 3,5-PYRIDINEDICARBOXYLIC ACID, 4-(1,3-BENZODIOXOL-5-YL)-1,4-DIHYDRO-2,6-DIMETHYL-, DIETHYL ESTER

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYLPYRIDINE-3,5-DICARBOXYLATE

1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER

3,5-DICARBETHOXY-1,4-DIHYDRO-2,4,6-TRIMETHYLPYRIDINE

3,5-DIETHOXYCARBONYL-1,4-DIHYDRO-2,4,6-COLLIDINE

5-pyridinedicarboxylicacid,1,4-dihydro-2,4,6-trimethyl-diethylester

Dicarbethoxydihydrocollidine

diethyl dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate

3,5-dicarbethoxy-1,4-dihydrocollidine, DDC

1,4-Dihydro-2,4,6-collidine-3,5-dicarboxylic acid diethyl ester

1,4-Dihydro-2,4,6-trimethylpyridine-3,5-dicarboxylic acid diethyl ester

1,4-Dihydro-3,5-dicarbethoxycollidine

3,5-Bis(ethoxycarbonyl)-1,4-dihydrocollidine

Diethyl 1,4-dihydro-s-collidine-3,5-dicarboxylate

Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate,99%

3,5-dicarbethoxy-1,4-dihydrocollidine

Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate,3,5-dicarbethoxy-1,4-dihydrocollidine, DDC

Diethyl 1,4-dihydro-2,4,6-triMethyl-3,5-pyridinedicarboxylate, 99% 25GR

1,4-Dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylic Acid Diethyl Ester Diethyl 1,4-Dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,4,6-triMethyl-, 3,5-diethyl ester

Diethyl 1,4-dihydro-2,4,6-triMethyl-3,5-pyridinedicarboxylate 99%

Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate

3,5-diethoxycarbonyl-1,4-dihydrocollidine

(4R)-2,4,6-trimethyl-3,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester

3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine &gt

DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE ISO 9001：2015 REACH

2,4,6-TRIMETHYL-1,4-DIHYDRO-PYRIDINE-3,5-DICARBOXYLIC ACID DIETHYL ESTER

632-93-9

C14H21NO4

Building Blocks

C9 to C46

Heterocyclic Building Blocks

Pyridines