ChemicalBook > CAS DataBase List > 2-IMINOTHIOLANE
2-IMINOTHIOLANE
- Product Name
- 2-IMINOTHIOLANE
- CAS No.
- 4781-83-3
- Chemical Name
- 2-IMINOTHIOLANE
- Synonyms
- 2-IMINOTHIOLANE HYDROCHLORIDE;TRAUT'S REAGENT;Nsc340007;2-Iminothiolane ,98%;dihydrothiophen-2(3H)-iMine;thiolan-2-iMine;2-IMINOTHIOLANE;2-IMINOTHIOLANE HCL;IMinothiolane hydrochlorid;2-THIOLANIMINE HYDROCHLORIDE
- CBNumber
- CB7373482
- Molecular Formula
- C4H7NS.ClH
- Formula Weight
- 137.63
- MOL File
- 4781-83-3.mol
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2-IMINOTHIOLANE Property
- Melting point:
- 198-201 °C(lit.)
- storage temp.
- 2-8°C
- solubility
- H2O: 100 mg/mL
- form
- powder
- color
- White to Off-White
- Water Solubility
- Freely soluble in water
- BRN
- 3620079
- CAS DataBase Reference
- 4781-83-3(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405Store locked up.
P501Dispose of contents/container to..…
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- I6256
- Product name
- 2-Iminothiolane hydrochloride
- Purity
- ≥98% (TLC), powder
- Packaging
- 100mg
- Price
- $68.3
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- I6256
- Product name
- 2-Iminothiolane hydrochloride
- Purity
- ≥98% (TLC), powder
- Packaging
- 1g
- Price
- $212.8
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- J60131
- Product name
- 2-Iminothiolane hydrochloride
- Packaging
- 250mg
- Price
- $178
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- J60131
- Product name
- 2-Iminothiolane hydrochloride
- Packaging
- 1g
- Price
- $267
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- I6256
- Product name
- 2-Iminothiolane hydrochloride
- Purity
- ≥98% (TLC), powder
- Packaging
- 500mg
- Price
- $256
- Updated
- 2024/03/01
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2-IMINOTHIOLANE Chemical Properties,Usage,Production
Chemical Properties
White Crystalline Solid
Uses
Cross-linking reagent cleavable by thiols.
Uses
2-Iminothiolane hydrochloride is predominantly used as an amine reactive at pH 7-10 and is also an effective thiolation reagent for polysaccharides. It is also used as a RNA-protein crosslinking reagent as well as useful in cross-linking proteins..
Uses
2-Iminothiolane hydrochloride is a valuable tool in studies of cellular organelles and oligomeric enzymes, using the techniques of protein-protein cross-linking. It may also be used to introduce reactive sulfhydryl groups into proteins for subsequent reaction with alkylating agents or heavy metal compounds.
General Description
2-Iminothiolane hydrochloride (2-IT.HCl), a protein modification reagent, is commonly employed to attach thiol groups to proteins and peptides. Raman spectroscopic analysis of hair keratin fibers modified with 2-IT.HCl showed the formation of new disulfide groups.
Purification Methods
Recrystallise the hydrochloride from MeOH/Et2O (m 187-192o) or (MeOH/Me2CO), but after sublimation at ~180o/0.2mm the melting point rises to 202-203o. It has 1HNMR with 2.27 (2H, t), 3.25 (2H, t) and 3.52 (2H, t) in (CD3)2SO. [King et al. Biochemistry 17 1499 1978.] The free base is purifed by vacuum distillation (b 71-72o/6mm) with IR (film) with 1700 (C=N)cm-1 and 1HNMR (CDCl3) with at 3.58 (2H, t) and max 2.10-2.8 (4H, m). The free base is stable on storage but slowly hydrolyses in aqueous solutions with half-lives at 25o of 390hours at pH 9.1, 210hours at pH 10 and 18hours at pH 11. [Traut et al. Biochemistry 12 3266 1973, Biochemistry 17 399 1978, Alagon & King Biochemistry 19 4343 1980, Beilstein 17/9 V 12.]
2-IMINOTHIOLANE Preparation Products And Raw materials
Raw materials
Preparation Products
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