(S)-(-)-3-CYCLOHEXENECARBOXYLIC ACID

Product Name: (S)-(-)-3-CYCLOHEXENECARBOXYLIC ACID
CAS No.: 5708-19-0
Chemical Name: (S)-(-)-3-CYCLOHEXENECARBOXYLIC ACID
Synonyms: (S)-cyclohex-3-ene-1-carboxylic acid;(S)-Cyclohex-3-enecarboxylic acid;(S)-3-Cyclohexene-1-carboxylic Acid;(1S)-cyclohex-3-ene-1-carboxylic acid;(S)-(-)-3-CYCLOHEXENEC;(S)-(-)-3-CYCLOHEXENECARBOXYLICA;(1S)-3-cyclohexenecarboxylic acid;(S)-(-)-3-Cyclohexenecaboxylic acid;(S)-(-)-3-cyclohexencarboxylic acid;(1S)-cyclohex-3-ene-1-carboxylicaci
CBNumber: CB7374252
Molecular Formula: C7H10O2
Formula Weight: 126.15
MOL File: 5708-19-0.mol

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(S)-(-)-3-CYCLOHEXENECARBOXYLIC ACID Property

Melting point:: 19°C(lit.)
Boiling point:: 118°C/6mmHg(lit.)
Density: 1.126±0.06 g/cm3(Predicted)
refractive index: 1.4780 to 1.4820
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: clear liquid
pka: 4.67±0.20(Predicted)
color: Colorless to Almost colorless
InChI: InChI=1S/C7H10O2/c8-7(9)6-4-2-1-3-5-6/h1-2,6H,3-5H2,(H,8,9)/t6-/m1/s1
InChIKey: VUSWCWPCANWBFG-ZCFIWIBFSA-N
SMILES: [C@H]1(C(O)=O)CCC=CC1

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Safety

Hazard Codes: C
Risk Statements: 34
Safety Statements: 26-36/37/39-45
RIDADR: UN 3265 8 / PGIII
HazardClass: 8
PackingGroup: III
HS Code: 2916200090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C3236
Product name: (S)-(-)-3-Cyclohexene-1-carboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $81
Updated: 2025/07/31

TRC

Product number: C988285
Product name: (S)-(-)-3-Cyclohexene-1-carboxylic Acid
Packaging: 500mg
Price: $160
Updated: 2021/12/16

TRC

Product number: C988285
Product name: (S)-(-)-3-Cyclohexene-1-carboxylic Acid
Packaging: 5g
Price: $1260
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC137309
Product name: (S)-(-)-3-Cyclohexene-1-carboxylic acid
Packaging: 10g
Price: $130
Updated: 2021/12/16

AK Scientific

Product number: 9066AH
Product name: (S)-(-)-3-Cyclohexenecarboxylicacid
Packaging: 5g
Price: $27
Updated: 2021/12/16

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(S)-(-)-3-CYCLOHEXENECARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

(S)-(-)-3-CYCLOHEXENECARBOXYLIC ACID can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.

Uses

(S)-3-Cyclohexene-1-carboxylic Acid has been used as a reactant for the preparation of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride, a potent and orally active direct inhibitor of factor Xa.

Synthesis

54.94 g of cyclohex-3-ene-1(S)-carboxylic acid (R)-(+)-methylbenzylamine salt and 18.2 volumes of H2O were charged to a flask at 20-25°C and stirred. To the mixture obtained further 6.7 volumes of H2O and 10 volumes of EtOAc were added. The mixture obtained was stirred for 15 min, the phases were separated and the organic layer was discarded. The aqueous layer was treated with 10 volumes of MTBE and 2.5 equivalents of 6M HCI were added slowly. The mixture obtained was stirred and two layers were formed, separated and the aqueous layer was extracted with MTBE. The organic layers obtained were combined and washed with aqueous, 30percent NaCl solution. The organic phase obtained was dried over Na2S04, filtered, and from the filtrate obtained solvent was removed in vacuo. Cyclohex-3-ene-1(S)-carboxylic acid in the form of a clear oil was obtained. Yield: 26.13 g (93.3percent of theory).

References

[1] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 3, p. 1193 - 1206
[2] Patent: EP2390245, 2011, A1. Location in patent: Page/Page column 15
[3] Patent: EP2399904, 2011, A1. Location in patent: Page/Page column 25
[4] Patent: EP1577301, 2005, A1. Location in patent: Page/Page column 191
[5] Patent: EP1405852, 2004, A1. Location in patent: Page 175

(S)-(-)-3-CYCLOHEXENECARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-(-)-3-CYCLOHEXENECARBOXYLIC ACID Suppliers

Americas 1 Australia 1 Austria 1 China 254 Europe 1 Germany 2 India 7 Japan 3 Switzerland 1 The Netherlands 1 United Kingdom 6 United States 25 Global 303

ZhengZhou Yimi Pharma R&D Co.,LTD.

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View Lastest Price from (S)-(-)-3-CYCLOHEXENECARBOXYLIC ACID manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: (S)-(-)-3-Cyclohexenecarboxylic acid 5708-19-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-28

Zhengzhou Anbu Chem Co.,Ltd

Product: (S)-(-)-3-CYCLOHEXENECARBOXYLIC ACID 5708-19-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1000KGS
Release date: 2023-04-24

Zhengzhou Anbu Chem Co.,Ltd

Product: (S)-(-)-3-CYCLOHEXENECARBOXYLIC ACID 5708-19-0
Price: US $0.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: 1000KGS
Release date: 2023-06-13

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