BOC-BETA-CHLORO-ALA-OH

BOC-BETA-CHLORO-ALA-OH Property

Boiling point:

340.9±32.0 °C(Predicted)

Density 

1.247±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,2-8°C

pka

3.23±0.10(Predicted)

Appearance

White to off-white Solid

Safety

HazardClass 

IRRITANT

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P330Rinse mouth.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

BOC-BETA-CHLORO-ALA-OH Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Synthesis

GENERAL STEPS: Example 1 Preparation of N-(tert-butoxycarbonyl)-3-chloro-L-alanine To a 50% aqueous 1,4-dioxane solution containing 1.0 g (6.25 mmol) of 3-chloro-L-alanine and 1.3 mL of triethylamine, 1.69 g (6.90 mmol) of 2-(tert-butoxycarbonyloxyimino)-2-phenylacetonitrile was slowly added under stirring at room temperature. After the reaction lasted for 2 hours, the reaction mixture was poured into 20 mL of water and extracted twice with ethyl acetate. The organic layers were combined and washed sequentially with water twice and saturated brine once, followed by drying with anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give 0.66 g (40.5% yield) of white solid product. For further purification, recrystallization was carried out using a solvent mixture of ethyl acetate and n-hexane to give 0.58 g of pure product (35.6% yield) with a melting point of 123-124 °C (decomposition). The structure of the product was confirmed by IR and NMR analysis.

References

[1] Patent: US4888427, 1989, A