DIFFRACTIC ACID
- Product Name
- DIFFRACTIC ACID
- CAS No.
- 436-32-8
- Chemical Name
- DIFFRACTIC ACID
- Synonyms
- NSC 5901;NSC 685595;DIFFRACTIC ACID;DIRHIZONIC ACID;diffractaicacid;Difractaic acid;diffracfaic acid;DIFFRACTAIC ACID(SH);DIFFRACTIC ACID USP/EP/BP;beta-resorcylicacid,3,6-dimethyl-,4-(2,4-dimethoxy-3,6-dimethylbenzoate)
- CBNumber
- CB7381496
- Molecular Formula
- C20H22O7
- Formula Weight
- 374.38
- MOL File
- 436-32-8.mol
DIFFRACTIC ACID Property
- Melting point:
- 189～190℃
- Boiling point:
- 604.9±55.0 °C(Predicted)
- Density
- 1.260±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
- form
- A solid
- pka
- 2.66±0.25(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 24208
- Product name
- Diffractaic Acid
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 24208
- Product name
- Diffractaic Acid
- Purity
- ≥95%
- Packaging
- 2.5mg
- Price
- $452
- Updated
- 2024/03/01
- Product number
- API0016143
- Product name
- DIFFRACTAIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.84
- Updated
- 2021/12/16
- Product number
- 6620CA
- Product name
- Diffractaicacid
- Packaging
- 25mg
- Price
- $590
- Updated
- 2021/12/16
- Product number
- XD165792
- Product name
- Diffractic acid
- Packaging
- 1mg
- Price
- $60
- Updated
- 2021/12/16
DIFFRACTIC ACID Chemical Properties,Usage,Production
Description
Diffractaic acid is a lichen metabolite that has been found in P. magellanica and has diverse biological activities. It is cytotoxic to HCT116, HeLa, and MCF-7 cancer cells (IC50s = 42.2, 64.6, and 93.4 μM, respectively). Diffractaic acid inhibits growth of M. tuberculosis (MIC = 41.7 μM). In vivo, diffractaic acid (25-200 mg/kg) reduces neutrophil infiltration, lipid peroxidation, myeloperoxidase (MPx) activity, and the number of gastric lesions as well as reverses decreases in superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities induced by indomethacin in rat gastric mucosa. Diffractaic acid also has analgesic activity, reducing acetic acid-induced writhing and increasing the pressure pain threshold in mice.
Chemical Properties
Powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., from Pinellia Usnea diffracta Vain, Ginseng family Dioscorea Rehmannia glutinosa (Gaetn.) Libosch. ex Fisch. et Mey.
Uses
Diffractaic acid, a major constituent of U. longissimi, acts as an effective proapoptotic agent in various disorders research[1]. Diffractaic acid is the analgesic and antipyretic component of Usnea diffracta[2].
Definition
ChEBI: 4-[(2,4-dimethoxy-3,6-dimethylphenyl)-oxomethoxy]-2-hydroxy-3,6-dimethylbenzoic acid is a carbonyl compound.
in vivo
Diffractaic acid shows an analgesic effect by Acetic acid-induced writhing and tail-pressure methods in mice[2].
References
[1] Fehmi Odabasoglu, et al. Diffractaic acid, a novel proapoptotic agent, induces with olive oil both apoptosis and antioxidative systems in Ti-implanted rabbits. Eur J Pharmacol. 2012 Jan 15;674(2-3):171-8. DOI:10.1016/j.ejphar.2011.11.019
[2] E Okuyama, et al. Usnic acid and diffractaic acid as analgesic and antipyretic components of Usnea diffracta. Planta Med. 1995 Apr;61(2):113-5. DOI:10.1055/s-2006-958027
DIFFRACTIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from DIFFRACTIC ACID manufacturers
- Product
- 4-(2,4-dimethoxy-3,6-dimethylbenzoyl)oxy-2-hydroxy-3,6-dimethylbenzoic acid 436-32-8
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-09