ETHYL 4-BROMO-1H-PYRROLE-2-CARBOXYLATE
Application- Product Name
- ETHYL 4-BROMO-1H-PYRROLE-2-CARBOXYLATE
- CAS No.
- 433267-55-1
- Chemical Name
- ETHYL 4-BROMO-1H-PYRROLE-2-CARBOXYLATE
- Synonyms
- EOS-60603;RARECHEM AL BI 1264;Ethyl 4-bromopyrrole-2-carboxylate;ETHYL 4-BROMO-1H-PYRROLE-2-CARBOXYLATE;Ethyl 4-bromopyrrole-2-carboxylate 97%;433267-55-1;4-Bromo-1H-pyrrole-2-carboxylic acid ethyl ester;1H-Pyrrole-2-carboxylic acid, 4-broMo-, ethyl ester;ENCHEM 4-BROMO-1H-PYRROLE-2-CARBOXYLIC ACID ETHYL ESTER 433267-55-1
- CBNumber
- CB7384280
- Molecular Formula
- C7H8BrNO2
- Formula Weight
- 218.05
- MOL File
- 433267-55-1.mol
ETHYL 4-BROMO-1H-PYRROLE-2-CARBOXYLATE Property
- Melting point:
- 58-63°C
- Boiling point:
- 301.7±22.0 °C(Predicted)
- Density
- 1.576±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- solid
- pka
- 13.58±0.50(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 729787
- Product name
- Ethyl 4-bromopyrrole-2-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $52.36
- Updated
- 2025/07/31
- Product number
- B124953
- Product name
- Ethyl4-Bromo-1H-pyrrole-2-carboxylate
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 3377AL
- Product name
- Ethyl4-bromo-1H-pyrrole-2-carboxylate
- Packaging
- 250mg
- Price
- $93
- Updated
- 2021/12/16
- Product number
- HCH0368868
- Product name
- ETHYL-4-BROMO-1H-PYRROLE-2-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.81
- Updated
- 2021/12/16
- Product number
- 3377AL
- Product name
- Ethyl4-bromo-1H-pyrrole-2-carboxylate
- Packaging
- 25g
- Price
- $836
- Updated
- 2021/12/16
ETHYL 4-BROMO-1H-PYRROLE-2-CARBOXYLATE Chemical Properties,Usage,Production
Application
Ethyl 4-bromo-1H-pyrrole-2-carboxylic acid ester can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly in laboratory research and development and chemical production processes.
Synthesis
72652-32-5
141-52-6
433267-55-1
Anhydrous ethanol (950.0 kg) was added to a 3000 L glass-lined reactor followed by 1-(4-bromo-1H-pyrrol-2-yl)-2,2,2-trichloroacetophenone (342.7 kg), keeping the reaction temperature at 20-30 °C. The reaction mixture was cooled to 0-5°C over about 2 hours. At this temperature, 21% sodium ethanol solution (36.4 kg) was slowly added dropwise over 1-1.5 hours. Upon completion of the dropwise addition, the reaction mixture was warmed to 25-30 °C and monitored to ensure that the content of 1-(4-bromo-1H-pyrrol-2-yl)-2,2,2-trichloroacetophenone was reduced to <1.0%. Subsequently, the reaction mixture was concentrated at a temperature not exceeding 50 °C until the remaining volume was 1.3-1.4 times the original volume. The concentrate was cooled to 25-30 °C and quenched by slowly pouring it into cold water (3427.0 kg) over about 2 hours. After quenching, the mixture was stirred at 0-5°C for about 2 hours to promote crystallization. After crystallization was completed, the solid product was separated by filtration and the filter cake was washed with cold water. Finally, the resulting solid was dried at 30-40 °C for 40-45 h to afford ethyl 4-bromo-1H-pyrrole-2-carboxylate (234.3 kg) with 99.9% purity and 91.3% yield.
References
[1] Journal of Organic Chemistry, 2015, vol. 80, # 12, p. 6001 - 6011
[2] Patent: WO2015/31562, 2015, A1. Location in patent: Page/Page column 19; 25
ETHYL 4-BROMO-1H-PYRROLE-2-CARBOXYLATE Preparation Products And Raw materials
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View Lastest Price from ETHYL 4-BROMO-1H-PYRROLE-2-CARBOXYLATE manufacturers
- Product
- ETHYL 4-BROMO-1H-PYRROLE-2-CARBOXYLATE 433267-55-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500kg
- Release date
- 2018-08-19