LOGANIC ACID

Product Name: LOGANIC ACID
CAS No.: 22255-40-9
Chemical Name: LOGANIC ACID
Synonyms: Loganate;Norloganin;loganicaci;LOGANIC ACID;Margannic acid;Loganic acid-RM;LOGANIC ACID hplc;LOGANIC ACID WITH HPLC;Fluoroestradiol Impurity 37;Loganic acid, 10 mM in DMSO
CBNumber: CB7384543
Molecular Formula: C16H24O10
Formula Weight: 376.36
MOL File: 22255-40-9.mol

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LOGANIC ACID Property

Boiling point:: 646.3±55.0 °C(Predicted)
Density: 1.60±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in methan
form: powder
pka: 4.55±0.70(Predicted)
color: White-beige
LogP: -2.411 (est)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SMB00231
Product name: Loganic acid
Purity: ≥95% (LC/MS-ELSD)
Packaging: 1mg
Price: $477
Updated: 2025/07/31

TCI Chemical

Product number: L0323
Product name: Loganic Acid
Packaging: 50MG
Price: $357
Updated: 2025/07/31

Cayman Chemical

Product number: 28402
Product name: Loganic Acid
Packaging: 25mg
Price: $656
Updated: 2024/03/01

Cayman Chemical

Product number: 28402
Product name: Loganic Acid
Packaging: 50mg
Price: $984
Updated: 2024/03/01

Cayman Chemical

Product number: 28402
Product name: Loganic Acid
Packaging: 5mg
Price: $166
Updated: 2024/03/01

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LOGANIC ACID Chemical Properties,Usage,Production

Description

Loganic acid is an iridoid glycoside that has been found in C. mas and has diverse biological activities, including antidiabetic, antiadipogenic, anti-atherosclerotic, and anti-inflammatory properties. Loganic acid (1 μM) stimulates glucagon-like peptide-1 (GLP-1) secretion by NCI H716 human enteroendocrine colorectal cancer cells. It inhibits dexamethasone-, 3-isobutyl-1-methylxanthine-, and insulin-induced differentiation of mouse 3T3-L1 fibroblasts into adipocytes when used at a concentration of 10 μg/ml. Loganic acid (20 mg/kg per day) decreases the plasma atherogenic index, a ratio of triglyceride to HDL cholesterol, and the cardiac risk ratio, a ratio of total cholesterol to HDL cholesterol, in a rabbit model of atherosclerosis induced by a cholesterol-rich diet. It also decreases IL-6, TNF-α, and oxidized LDL (oxLDL) plasma levels in the same model.

Chemical Properties

Off-white crystalline powder, soluble in methanol, derived from Gentiana macrophylla.

Uses

Loganic Acid is found to be present in both the fermented fruits and brines. Exhibits antioxidant activity.

Definition

ChEBI: A cyclopentapyran that is 1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylic acid substituted at positions 1, 6 and 7 by beta-D-glucosyloxy, hydroxy and methyl groups respectively

References

[1] CARMINE J. COSCIA Luigi B Rocco Guarnaccia. Monoterpene biosynthesis. I. Occurrence and mevalonoid origin of gentiopicroside and loganic acid in Swertia caroliniensis[J]. Biochemistry Biochemistry, 1969, 8 12: 5036-5043. DOI: 10.1021/bi00840a054
[2] HYO-WEON SUH . A bitter herbal medicine Gentiana scabra root extract stimulates glucagon-like peptide-1 secretion and regulates blood glucose in db/db mouse[J]. Journal of ethnopharmacology, 2015, 172: Pages 219-226. DOI: 10.1016/j.jep.2015.06.042
[3] EUNKUK PARK. Antiadipogenic Effects of Loganic Acid in 3T3-L1 Preadipocytes and Ovariectomized Mice.[J]. Molecules, 2018, 23 7. DOI: 10.3390/molecules23071663
[4] TOMASZ SOZA?SKI . Iridoid–loganic acid versus anthocyanins from the Cornus mas fruits (cornelian cherry): Common and different effects on diet-induced atherosclerosis, PPARs expression and inflammation[J]. Atherosclerosis, 2016, 254: Pages 151-160. DOI: 10.1016/j.atherosclerosis.2016.10.001

LOGANIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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LOGANIC ACID Suppliers

China 226 France 2 Germany 3 United Kingdom 6 United States 23 Global 260

AdooQ BioScience, LLC

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View Lastest Price from LOGANIC ACID manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Loganic acid 22255-40-9
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-11-15

Zhuozhou Wenxi import and Export Co., Ltd

Product: LOGANIC ACID 22255-40-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: LOGANIC ACID 22255-40-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: KG/T
Release date: 2019-12-18

22255-40-9, LOGANIC ACIDRelated Search:

Loganin Isobutyl vinyl ether 1,1-Dimethoxyoctane 1,8-Octanediol BUTYL-BETA-D-GLUCOPYRANOSIDE n-Octyl-β-D-glucopyranoside 1,4-Butanediol vinyl ether VINYLCYCLOPENTANE HEPTYL-BETA-D-GLUCOPYRANOSIDE CYCLOPENTYLACETIC ACID 3,4-DIHYDRO-2-METHOXY-2H-PYRAN 3-ETHOXYMETHACROLEIN HEPTANAL DIMETHYL ACETAL 3-ETHOXYACRYLIC ACID LOGANIC ACID HEXANAL DIMETHYL ACETAL N-OCTYLMONOOXYETHYLENE 2-ETHOXY-3,4-DIHYDRO-2H-PYRAN

LOGANIC ACID

[1S-(1alpha,4aalpha,6alpha,7alpha,7aalpha)]-1-(beta-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-6-hydroxy-7-methylcyclopenta[c]pyran-4-carboxylic acid

(1S-(1alpha,4aalpha,6alpha,7alpha,7aalpha))-1-(beta-D-Glucopyranosylox y)-1,4a,5,6,7,7a-hexahydro-6-hydroxy-7-methylcyclopenta(c)pyran-4-carb oxylic acid

LOGANIC ACID hplc

LOGANIC ACID WITH HPLC

(1S)-1α-(β-D-Glucopyranosyloxy)-6α-hydroxy-7α-methyl-1,4aα,5,6,7,7aα-hexahydrocyclopenta[c]pyran-4-carboxylic acid

[1S-(1a,4aa,6a,7a,7aa)]-1-(beta-D-Glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-6-hydroxy-7-methylcyclopenta[c]pyran-4-carboxylic acid

[1S-(1α,4aα,6α,7α,7aα)]-1-(β-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-6-hydroxy-7-methylcyclopenta[c]pyran-4-carboxylic acid

Loganate

Norloganin

Loganic acid, 98%, from Cornus officinalis Sieb. & Zucc.

Cyclopenta[c]pyran-4-carboxylic acid, 1-(β-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-6-hydroxy-7-methyl-, (1S,4aS,6S,7R,7aS)-

Loganic acid >=95% (LC/MS-ELSD)

loganicaci

[1S-(1α,4aα,6α,7α,7aα)]-1-(β-D-glucopyranosyloxy)-1,4a...

(1S,4aS,6S,7R,7aS)-6-Hydroxy-7-methyl-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylic acid

Margannic acid

Loganic acid-RM

Fluoroestradiol Impurity 37

Loganic acid, 10 mM in DMSO

22255-40-9

C16H24O10

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Iridoids