5-CYANO-3-IODOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Product Name
- 5-CYANO-3-IODOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS No.
- 864685-26-7
- Chemical Name
- 5-CYANO-3-IODOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Synonyms
- 1-BOC-5-CYANO-3-IODO-INDOLE;1-Boc-3-iodoindole-5-carbonitrile;5-CYANO-3-IODOINDOLE, N-BOC PROTECTED;1-Boc-3-iodoindole-5-carbonitrile,97%;5-Cyano-3-iodoindole-1-carboxylic acid;5-Cyano-3-iodo-1H-indole,N-BOCprotected98%;tert-Butyl 5-cyano-3-iodo-1H-indole-1-carboxylate;5-cyano-3-iodo-1-indolecarboxylic acid tert-butyl ester;5-CYANO-3-IODOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1H-Indole-1-carboxylic acid, 5-cyano-3-iodo-, 1,1-diMethylethyl ester
- CBNumber
- CB7390199
- Molecular Formula
- C14H13IN2O2
- Formula Weight
- 368.17
- MOL File
- 864685-26-7.mol
5-CYANO-3-IODOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property
- Boiling point:
- 452.3±48.0 °C(Predicted)
- Density
- 1.58±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- Solid
- color
- Pale yellow
- Sensitive
- Light Sensitive
- InChI
- InChI=1S/C14H13IN2O2/c1-14(2,3)19-13(18)17-8-11(15)10-6-9(7-16)4-5-12(10)17/h4-6,8H,1-3H3
- InChIKey
- GADLXNFRAAUWAD-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)C2=C(C=C(C#N)C=C2)C(I)=C1
Safety
- Hazard Codes
- Xi
- HazardClass
- 6.1
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- FB149488
- Product name
- 1-Boc-5-cyano-3-iodo-indole
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 4H48-H-X0
- Product name
- 5-Cyano-3-iodo-1H-indole, N-Boc protected
- Purity
- 98%
- Packaging
- 1g
- Price
- $76
- Updated
- 2021/12/16
- Product number
- FB149488
- Product name
- 1-Boc-5-cyano-3-iodo-indole
- Packaging
- 1g
- Price
- $103
- Updated
- 2021/12/16
- Product number
- COR0003341
- Product name
- 1-BOC-5-CYANO-3-IODO-INDOLE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $114
- Updated
- 2021/12/16
- Product number
- FB149488
- Product name
- 1-Boc-5-cyano-3-iodo-indole
- Packaging
- 2g
- Price
- $179
- Updated
- 2021/12/16
5-CYANO-3-IODOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production
Synthesis
1092114-59-4
24424-99-5
864685-26-7
The general procedure for the synthesis of tert-butyl 5-amino-3-iodo-1H-indole-1-carboxylate from 3-iodo-1H-indole-5-cyano and di-tert-butyl dicarbonate was as follows: 5-cyano-3-iodoindole (0.700 g, 2.61 mmol) was dissolved in dichloromethane (40 mL), and di-tert-butyl dicarbonate (0.627 g, 2.87 mmol) was added sequentially, triethylamine (1.09 mL, 7.83 mmol) and 4-dimethylaminopyridine (32.0 mg, 0.261 mmol). The reaction mixture was stirred at room temperature for 40 min. After completion of the reaction, the reaction mixture was diluted with ethyl acetate and washed sequentially with 1 mol/L hydrochloric acid and saturated brine. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give 1-tert-butoxycarbonyl-5-cyano-3-iodoindole (0.958 g, quantitative yield). esi-ms: m/z 369 [M + H]+.
References
[1] Patent: EP2163554, 2010, A1. Location in patent: Page/Page column 107
5-CYANO-3-IODOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-CYANO-3-IODOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers
- Product
- 5-CYANO-3-IODOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 864685-26-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 5-CYANO-3-IODOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 864685-26-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09