3-BROMO-5-METHOXYBENZALDEHYDE
- Product Name
- 3-BROMO-5-METHOXYBENZALDEHYDE
- CAS No.
- 262450-65-7
- Chemical Name
- 3-BROMO-5-METHOXYBENZALDEHYDE
- Synonyms
- 5-BROMO-3-METHOXYBENZALDEHYDE;3-BROMO-5-METHOXYBENZALDEHYDE;3-BroMo-5-Methoxybznzaldehyde;Benzaldehyde, 3-broMo-5-Methoxy-;3-BROMO-5-METHOXYBENZALDEHYDE USP/EP/BP;3-Bromo-5-formylanisole, 5-Bromo-m-anisaldehyde
- CBNumber
- CB7391439
- Molecular Formula
- C8H7BrO2
- Formula Weight
- 215.04
- MOL File
- Mol file
3-BROMO-5-METHOXYBENZALDEHYDE Property
- Melting point:
- 45-46 °C
- Boiling point:
- 279.5±20.0 °C(Predicted)
- Density
- 1.522±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- solid
- color
- Off-white to yellow
Safety
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B685215
- Product name
- 3-Bromo-5-methoxybenzaldehyde
- Packaging
- 10g
- Price
- $1320
- Updated
- 2021/12/16
- Product number
- 2615-9-X0
- Product name
- 3-Bromo-5-methoxybenzaldehyde
- Packaging
- 5G
- Price
- $205
- Updated
- 2021/12/16
- Product number
- FB67141
- Product name
- 5-Bromo-3-methoxybenzaldehyde
- Packaging
- 10g
- Price
- $220
- Updated
- 2021/12/16
- Product number
- HCH0034658
- Product name
- 3-BROMO-5-METHOXY BENZALDEHYDE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1292.12
- Updated
- 2021/12/16
- Product number
- J99114
- Product name
- 3-Bromo-5-methoxybenzaldehyde
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
3-BROMO-5-METHOXYBENZALDEHYDE Chemical Properties,Usage,Production
Uses
3-Bromo-5-methoxybenzaldehyde, can be used for the synthesis of novel scaffold, that led to the discovery of potent and selective Inhibitors of Dihydrofolate Reductase, used for the treatment of Cryptosporidiosis. It can also be used for the synthesis of Tetrahydrobenzoxepino[2,3,4-ij]isoquinolines derivatives, as Dopamine Receptor ligands.
Synthesis
199177-26-9
74-88-4
262450-65-7
Example 1 5A: Synthesis of 3-bromo-5-methoxybenzaldehyde 3-Bromo-5-hydroxybenzaldehyde (0.5 g, 2.487 mmol) was dissolved in N,N-dimethylformamide (DMF, 14.63 mL) and the solution was cooled to 0 °C. Under stirring, sodium hydride (NaH, 0.119 g, 4.97 mmol) was added in three batches. Subsequently, the reaction mixture was slowly warmed to room temperature and iodomethane (MeI, 0.933 mL, 14.92 mmol) was added. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the reaction mixture was diluted with water and partially concentrated under reduced pressure. The concentrate was diluted with dichloromethane (DCM), washed twice sequentially with water and once with saturated brine, and then dried over anhydrous sodium sulfate (Na2SO4). After filtration to remove the desiccant, the filtrate was concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with an elution gradient of 0 to 100% ethyl acetate (EtOAc) in hexane solution to give the title compound Example 15A (0.488 g, 2.27 mmol, 9% yield). 1H NMR (400 MHz, chloroform-d) δ 9.91 (1H, s), 7.58 (1H, t, J = 1.38 Hz), 7.28-7.35 (2H, m), 3.86 (3H, s).
References
[1] Patent: WO2014/201073, 2014, A1. Location in patent: Paragraph 00295
[2] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 1, p. 67 - 72
3-BROMO-5-METHOXYBENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-BROMO-5-METHOXYBENZALDEHYDE manufacturers
- Product
- 3-BROMO-5-METHOXYBENZALDEHYDE 262450-65-7
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-10-24
- Product
- 3-BROMO-5-METHOXYBENZALDEHYDE 262450-65-7
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 10000MT
- Release date
- 2023-08-08
- Product
- 3-BROMO-5-METHOXYBENZALDEHYDE 262450-65-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-09