ChemicalBook > CAS DataBase List > (3Z)-5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-1H-indol-2-one

(3Z)-5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-1H-indol-2-one

Product Name
(3Z)-5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-1H-indol-2-one
CAS No.
486443-73-6
Chemical Name
(3Z)-5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-1H-indol-2-one
Synonyms
LC3-mHTT-IN-AN1;LC3-mHTT-IN-AN1 (Compound AN1);LC3-mHTT-IN-AN1, 10 mM in DMSO;5-Bromo-3-(3-bromo-4,5-dihydroxybenzylidene)indolin-2-one;(3Z)-5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-1H-indol-2-one;2H-Indol-2-one, 5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylene]-1,3-dihydro-;Autophagosome-tethering compounds,LC3mHTTINAN1,Autophagy,LC3 mHTT IN AN1,ATTECs,Inhibitor,LC-3-mHTT-IN-AN1,inhibit
CBNumber
CB73915407
Molecular Formula
C15H9Br2NO3
Formula Weight
411.04
MOL File
486443-73-6.mol
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(3Z)-5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-1H-indol-2-one Property

storage temp. 
2-8°C
solubility 
DMSO: 125 mg/mL (304.11 mM)
form 
A solid
color 
Light yellow to yellow
Water Solubility 
Water: < 0.1 mg/mL (insoluble)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Ambeed
Product number
A1193421
Product name
5-Bromo-3-(3-bromo-4,5-dihydroxybenzylidene)indolin-2-one
Purity
96%
Packaging
5mg
Price
$72
Updated
2021/12/16
Ambeed
Product number
A1193421
Product name
5-Bromo-3-(3-bromo-4,5-dihydroxybenzylidene)indolin-2-one
Purity
96%
Packaging
10mg
Price
$94
Updated
2021/12/16
Ambeed
Product number
A1193421
Product name
5-Bromo-3-(3-bromo-4,5-dihydroxybenzylidene)indolin-2-one
Purity
96%
Packaging
50mg
Price
$159
Updated
2021/12/16
CSNpharm
Product number
CSN25321
Product name
LC3-mHTT-IN-AN1
Packaging
1mg
Price
$201
Updated
2021/12/16
Ambeed
Product number
A1193421
Product name
5-Bromo-3-(3-bromo-4,5-dihydroxybenzylidene)indolin-2-one
Purity
96%
Packaging
100mg
Price
$254
Updated
2021/12/16
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(3Z)-5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-1H-indol-2-one Chemical Properties,Usage,Production

Biological Activity

AN1 is a brain blood barrier penetrant agent th at tether LC3 and mHTT and targets mHTT for autophagosome degradation. AN1 significantly lower mHTT in cortices of HD mice, in cells from patients with Huntington′s disease, and neurons derived from induced pluripotent stem cells. AN1 does not lower wtHTT in fibroblasts from healthy human donors. It appears th at AN1 interact with the polyQ stretch.

(3Z)-5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-1H-indol-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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(3Z)-5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-1H-indol-2-one Suppliers

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486443-73-6, (3Z)-5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-1H-indol-2-oneRelated Search:


  • (3Z)-5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-1H-indol-2-one
  • LC3-mHTT-IN-AN1
  • 2H-Indol-2-one, 5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylene]-1,3-dihydro-
  • LC3-mHTT-IN-AN1 (Compound AN1)
  • 5-Bromo-3-(3-bromo-4,5-dihydroxybenzylidene)indolin-2-one
  • Autophagosome-tethering compounds,LC3mHTTINAN1,Autophagy,LC3 mHTT IN AN1,ATTECs,Inhibitor,LC-3-mHTT-IN-AN1,inhibit
  • LC3-mHTT-IN-AN1, 10 mM in DMSO
  • 486443-73-6