2-Bromo-5-methylbenzenamine
- Product Name
- 2-Bromo-5-methylbenzenamine
- CAS No.
- 53078-85-6
- Chemical Name
- 2-Bromo-5-methylbenzenamine
- Synonyms
- CHEMPACIFIC 39968;6-Bromo-m-toluidine;2-Bromo-5-methylbenz;2-BroMo-5-Methylanline;2-BROMO-5-METHYLANILINE;2-Bromo-5-methylaniline 98%;2-bromo-5-methylbenzenamine;2-Bromo-5-methylaniline >2-BROMO-5-METHYL-PHENYLAMINE;Benzenamine, 2-bromo-5-methyl-
- CBNumber
- CB7395194
- Molecular Formula
- C7H8BrN
- Formula Weight
- 186.05
- MOL File
- 53078-85-6.mol
2-Bromo-5-methylbenzenamine Property
- Melting point:
- 46°C
- Boiling point:
- 130°C/16mmHg(lit.)
- Density
- 1.486 g/mL at 25 °C
- refractive index
- n20/D 1.603
- Flash point:
- 110 °C
- storage temp.
- 2-8°C
- form
- Solid
- pka
- 2.66±0.10(Predicted)
- color
- White to Orange to Green
- InChI
- InChI=1S/C7H8BrN/c1-5-2-3-6(8)7(9)4-5/h2-4H,9H2,1H3
- InChIKey
- QTAQWOXSUFGGKH-UHFFFAOYSA-N
- SMILES
- C1(N)=CC(C)=CC=C1Br
- CAS DataBase Reference
- 53078-85-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38-20/21/22
- Safety Statements
- 9-26-36/37-60
- RIDADR
- 2811
- WGK Germany
- 3
- HazardClass
- 6.1
- HS Code
- 29214300
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 686409
- Product name
- 2-Bromo-5-methylaniline
- Purity
- 97%
- Packaging
- 5g
- Price
- $35.3
- Updated
- 2025/07/31
- Product number
- 686409
- Product name
- 2-Bromo-5-methylaniline
- Purity
- 97%
- Packaging
- 25g
- Price
- $118
- Updated
- 2025/07/31
- Product number
- B4507
- Product name
- 2-Bromo-5-methylaniline
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $49
- Updated
- 2025/07/31
- Product number
- B4507
- Product name
- 2-Bromo-5-methylaniline
- Purity
- >97.0%(GC)(T)
- Packaging
- 25g
- Price
- $193
- Updated
- 2025/07/31
- Product number
- B808290
- Product name
- 2-Bromo-5-methylaniline
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
2-Bromo-5-methylbenzenamine Chemical Properties,Usage,Production
Chemical Properties
Brown crystal
Uses
2-Bromo-5-methylbenzenamine is an intermediate for synthesizing new indole anticancer drugs, antihypertensive drug reserpine, triptan drugs for treating migraine, indomethacin for treating rheumatism and rheumatoid arthritis, etc.
Synthesis
5326-34-1
53078-85-6
Preparation Example 1: General procedure for the synthesis of 2-bromo-5-methylaniline 1. 4-Bromo-3-nitrotoluene (60.35 g, 279 mmol), 5 wt% platinum-carbon catalyst (1.09 g, 0.28 mmol), and triethylamine (112.93 g, 1116 mmol) were added sequentially to the reaction flask. 2. the reaction mixture was heated to 100 °C and 99% formic acid (42.39 g, 921 mmol) was added slowly and dropwise over a period of 20 minutes. 3. The reaction temperature was maintained with continuous stirring for 12 hours. 4. Upon completion of the reaction, cooled to room temperature, ethyl acetate (100 mL) and water (100 mL) were added to the reaction mixture with thorough stirring. 5. Filter through diatomaceous earth to remove the platinum carbon catalyst. 6. Add ethyl acetate (200 mL) and water (100 mL) to the filtrate and extract. 7. The organic phase was separated and washed with deionized water (300 mL x 3 times). 8. The organic phase was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford the target product 2-bromo-5-methylaniline (51.30 g, 276 mmol) in 99% yield. 9. The structure of the product was confirmed by 1H-NMR (270 MHz, CDCl3): δ (ppm) 7.260 (1H, d), 6.583 (1H, ... (data not provided in full)).
References
[1] Patent: US2003/191325, 2003, A1. Location in patent: Page/Page column 8
[2] Patent: EP1820799, 2007, A1
[3] Patent: WO2006/51851, 2006, A1. Location in patent: Page/Page column 59-60
[4] Patent: WO2012/65062, 2012, A1. Location in patent: Page/Page column 89-90
[5] Journal of Fluorine Chemistry, 2002, vol. 116, # 2, p. 173 - 179
2-Bromo-5-methylbenzenamine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromo-5-methylbenzenamine manufacturers
- Product
- 2-Bromo-5-methylbenzenamine 53078-85-6
- Price
- US $1.00/KG
- Min. Order
- 100g
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2019-12-17