(HYDROXYMETHYL)-2-PYRROLIDINONE

Uses

Product Name: (HYDROXYMETHYL)-2-PYRROLIDINONE
CAS No.: 15438-71-8
Chemical Name: (HYDROXYMETHYL)-2-PYRROLIDINONE
Synonyms: Ai3-28014;Einecs 239-451-5;IFLAB-BB F0861-0038;METHYLOLPYRROLIDONE;N-Methylol-2-pyrrolidinone;N-HYDROXYMETHYL PYRROLIDONE;1-Hydroxymethyl-2-pyrrolidone;1-Hydroxymethyl-2-pyrrolidinone;(HYDROXYMETHYL)-2-PYRROLIDINONE;N-(Hydroxymethyl)-2-pyrrolidone
CBNumber: CB7397305
Molecular Formula: C5H9NO2
Formula Weight: 115.13
MOL File: 15438-71-8.mol

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(HYDROXYMETHYL)-2-PYRROLIDINONE Property

Melting point:: 77-79.5 °C
Boiling point:: 185-188 °C(Press: 4 Torr)
Density: 1.213±0.06 g/cm3(Predicted)
pka: 13.41±0.10(Predicted)
CAS DataBase Reference: 15438-71-8(CAS DataBase Reference)
EPA Substance Registry System: 2-Pyrrolidinone, 1-(hydroxymethyl)- (15438-71-8)

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Safety

TSCA: TSCA listed

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S362557
Product name: 1-(HYDROXYMETHYL)-2-PYRROLIDINONE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $185
Updated: 2025/07/31

Sigma-Aldrich

Product number: S362557
Product name: 1-(HYDROXYMETHYL)-2-PYRROLIDINONE
Purity: Aldrich
Packaging: 250mg
Price: $179
Updated: 2024/03/01

Matrix Scientific

Product number: 180400
Product name: 1-(Hydroxymethyl)pyrrolidin-2-one
Packaging: 500mg
Price: $100
Updated: 2021/12/16

Matrix Scientific

Product number: 180400
Product name: 1-(Hydroxymethyl)pyrrolidin-2-one
Packaging: 1g
Price: $120
Updated: 2021/12/16

Matrix Scientific

Product number: 180400
Product name: 1-(Hydroxymethyl)pyrrolidin-2-one
Packaging: 5g
Price: $380
Updated: 2021/12/16

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(HYDROXYMETHYL)-2-PYRROLIDINONE Chemical Properties,Usage,Production

Uses

1-(hydroxymethyl)pyrrolidone-2-one can be used as a pharmaceutical synthesis intermediate. If 1-(hydroxymethyl)pyrrolidone-2-one is inhaled, move the patient to fresh air; if skin contact occurs, remove contaminated clothing and thoroughly wash the skin with soap and water. If discomfort persists, seek medical attention.

Synthesis

1-(Hydroxymethyl)pyrrolidin-2-one was prepared as follows: 2-pyrrolidinone (212.4 g, 2.0 mol) and potassium hydroxide (0.6 g) were heated to 80 ??C and oligoformaldehyde (75.6 g, 2.6 mol) was added within 10 min and the mixture was kept at 75 ??C - 80 ??C for 1/2 hour. The desired product was then crystallized from 1 part benzene to give 227 g of 1-(hydroxymethyl)pyrrolidin-2-one (88.2%) with a melting point product at 78°-80°C.

(HYDROXYMETHYL)-2-PYRROLIDINONE Preparation Products And Raw materials

Raw materials

Preparation Products

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(HYDROXYMETHYL)-2-PYRROLIDINONE Suppliers

Canada 1 China 25 France 1 India 1 South Korea 1 Switzerland 1 The Netherlands 1 United Kingdom 4 United States 10 Global 45

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15438-71-8, (HYDROXYMETHYL)-2-PYRROLIDINONERelated Search:

Z-D-PYR-OH Z-PYR-OH BOC-PYR-OH (S)-N-ALPHA-T-BUTYLOXYCARBONYL-PYROGLUTAMIC ACID T-BUTYL ESTER Streptolydigin (S)-(+)-5-HYDROXYMETHYL-2-PYRROLIDINONE 97%,(S)-(+)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE,(S)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE (S)-(+)-5-(Hydroxymethyl)-2-pyrrolidinone p-toluenesulfonate (R)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE,(R)-(-)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE,5-(Hydroxymethyl)-2-pyrrolidinone Z-PYR-OSU Z-PGLU-PRO-OBZL BOC-PYR-OH DCHA 1-(TERT-BUTOXYCARBONYL)-2-PYRROLIDINONE (+)-(3R,7aS)-Tetrahydro-3-phenyl-3H,5H-pyrrolo1,2-coxaole-5-one (4R)-BOC-4-BENZYL-PYR-OH Z-PYR-ONP (HYDROXYMETHYL)-2-PYRROLIDINONE N-hydroxymethylsuccinimide Z-PGLU-HIS-OH

N-HYDROXYMETHYL PYRROLIDONE

1-(HYDROXYMETHYL)PYRROLIDIN-2-ONE

METHYLOLPYRROLIDONE

IFLAB-BB F0861-0038

(HYDROXYMETHYL)-2-PYRROLIDINONE

1-(Hydroxymethyl)-2-pyrrolizinone

1-Hydroxymethyl-2-pyrrolidone

1-Hydroxymethyl-2-pyrrolidinone

2-Pyrrolidinone, 1-(hydroxymethyl)-

Ai3-28014

Einecs 239-451-5

N-(Hydroxymethyl)-2-pyrrolidinone

N-(Hydroxymethyl)-2-pyrrolidone

N-Methylol-2-pyrrolidinone

15438-71-8