(HYDROXYMETHYL)-2-PYRROLIDINONE

Uses

Product Name: (HYDROXYMETHYL)-2-PYRROLIDINONE
CAS No.: 15438-71-8
Chemical Name: (HYDROXYMETHYL)-2-PYRROLIDINONE
Synonyms: Ai3-28014;Einecs 239-451-5;IFLAB-BB F0861-0038;METHYLOLPYRROLIDONE;N-Methylol-2-pyrrolidinone;N-HYDROXYMETHYL PYRROLIDONE;1-Hydroxymethyl-2-pyrrolidone;1-Hydroxymethyl-2-pyrrolidinone;(HYDROXYMETHYL)-2-PYRROLIDINONE;N-(Hydroxymethyl)-2-pyrrolidone
CBNumber: CB7397305
Molecular Formula: C5H9NO2
Formula Weight: 115.13
MOL File: 15438-71-8.mol

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(HYDROXYMETHYL)-2-PYRROLIDINONE Property

Melting point:: 77-79.5 °C
Boiling point:: 185-188 °C(Press: 4 Torr)
Density: 1.213±0.06 g/cm3(Predicted)
pka: 13.41±0.10(Predicted)
CAS DataBase Reference: 15438-71-8(CAS DataBase Reference)
EPA Substance Registry System: 2-Pyrrolidinone, 1-(hydroxymethyl)- (15438-71-8)

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Safety

TSCA: TSCA listed

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S362557
Product name: 1-(HYDROXYMETHYL)-2-PYRROLIDINONE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $185
Updated: 2025/07/31

Sigma-Aldrich

Product number: S362557
Product name: 1-(HYDROXYMETHYL)-2-PYRROLIDINONE
Purity: Aldrich
Packaging: 250mg
Price: $179
Updated: 2024/03/01

Matrix Scientific

Product number: 180400
Product name: 1-(Hydroxymethyl)pyrrolidin-2-one
Packaging: 500mg
Price: $100
Updated: 2021/12/16

Matrix Scientific

Product number: 180400
Product name: 1-(Hydroxymethyl)pyrrolidin-2-one
Packaging: 1g
Price: $120
Updated: 2021/12/16

Matrix Scientific

Product number: 180400
Product name: 1-(Hydroxymethyl)pyrrolidin-2-one
Packaging: 5g
Price: $380
Updated: 2021/12/16

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(HYDROXYMETHYL)-2-PYRROLIDINONE Chemical Properties,Usage,Production

Uses

1-(hydroxymethyl)pyrrolidone-2-one can be used as a pharmaceutical synthesis intermediate. If 1-(hydroxymethyl)pyrrolidone-2-one is inhaled, move the patient to fresh air; if skin contact occurs, remove contaminated clothing and thoroughly wash the skin with soap and water. If discomfort persists, seek medical attention.

Synthesis

1-(Hydroxymethyl)pyrrolidin-2-one was prepared as follows: 2-pyrrolidinone (212.4 g, 2.0 mol) and potassium hydroxide (0.6 g) were heated to 80 C and oligoformaldehyde (75.6 g, 2.6 mol) was added within 10 min and the mixture was kept at 75 C - 80 C for 1/2 hour. The desired product was then crystallized from 1 part benzene to give 227 g of 1-(hydroxymethyl)pyrrolidin-2-one (88.2%) with a melting point product at 78°-80°C.

(HYDROXYMETHYL)-2-PYRROLIDINONE Preparation Products And Raw materials

Raw materials

Preparation Products

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(HYDROXYMETHYL)-2-PYRROLIDINONE Suppliers

Canada 1 China 25 France 1 India 1 South Korea 1 Switzerland 1 The Netherlands 1 United Kingdom 4 United States 10 Global 45

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15438-71-8, (HYDROXYMETHYL)-2-PYRROLIDINONERelated Search:

Z-D-PYR-OH Z-PYR-OH BOC-PYR-OH (S)-N-ALPHA-T-BUTYLOXYCARBONYL-PYROGLUTAMIC ACID T-BUTYL ESTER Streptolydigin (S)-(+)-5-HYDROXYMETHYL-2-PYRROLIDINONE 97%,(S)-(+)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE,(S)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE (S)-(+)-5-(Hydroxymethyl)-2-pyrrolidinone p-toluenesulfonate (R)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE,(R)-(-)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE,5-(Hydroxymethyl)-2-pyrrolidinone Z-PYR-OSU Z-PGLU-PRO-OBZL BOC-PYR-OH DCHA 1-(TERT-BUTOXYCARBONYL)-2-PYRROLIDINONE (+)-(3R,7aS)-Tetrahydro-3-phenyl-3H,5H-pyrrolo1,2-coxaole-5-one (4R)-BOC-4-BENZYL-PYR-OH Z-PYR-ONP (HYDROXYMETHYL)-2-PYRROLIDINONE N-hydroxymethylsuccinimide Z-PGLU-HIS-OH

N-HYDROXYMETHYL PYRROLIDONE

1-(HYDROXYMETHYL)PYRROLIDIN-2-ONE

METHYLOLPYRROLIDONE

IFLAB-BB F0861-0038

(HYDROXYMETHYL)-2-PYRROLIDINONE

1-(Hydroxymethyl)-2-pyrrolizinone

1-Hydroxymethyl-2-pyrrolidone

1-Hydroxymethyl-2-pyrrolidinone

2-Pyrrolidinone, 1-(hydroxymethyl)-

Ai3-28014

Einecs 239-451-5

N-(Hydroxymethyl)-2-pyrrolidinone

N-(Hydroxymethyl)-2-pyrrolidone

N-Methylol-2-pyrrolidinone

15438-71-8