MRS 1706

Product Name: MRS 1706
CAS No.: 264622-53-9
Chemical Name: MRS 1706
Synonyms: MRS 1706;MRS-1706, 10 mM in DMSO;MRS-1706;MRS 1706;MRS1706;N-(4-acetylphenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide;N-(4-ACETYLPHENYL)-2-[4-(2,3,6,7-TETRAHYDRO-2,6-DIOXO-1,3-DIPROPYL-1H-PURIN-8-YL)PHENOXY]ACETAMIDE;N-(4-Acetylphenyl)-2-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,9-tetrahydro-1H-purin-8-yl)phenoxy)acetamide;Acetamide, N-(4-acetylphenyl)-2-[4-(2,3,6,9-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-;MRS-1706,cAMP,P1 receptor,corpus cavernosal strips,duration,inhibit,MRS 1706,Adenosine Receptor,MRS1706,Inhibitor,adenosine,magnitude
CBNumber: CB7397486
Molecular Formula: C27H29N5O5
Formula Weight: 503.55
MOL File: 264622-53-9.mol

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MRS 1706 Property

Density: 1.293±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO : 6.4 mg/mL (12.71 mM; Need ultrasonic and warming)H2O : < 0.1 mg/mL (insoluble)
form: Powder
pka: 8.25±0.70(Predicted)
color: Off-white to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3089
Product name: MRS-1706
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $78.37
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3089
Product name: MRS-1706
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $332
Updated: 2025/07/31

Cayman Chemical

Product number: 17417
Product name: MRS1706
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17417
Product name: MRS1706
Purity: ≥95%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 17417
Product name: MRS1706
Purity: ≥95%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

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MRS 1706 Chemical Properties,Usage,Production

Description

MRS1706 is a selective adenosine A_2B receptor inverse agonist with K_i values of 1.39, 157, 112, and 230 nM for human A_2B, A₁, A_2A, and A₃ receptors, respectively.

Uses

MRS 1706 is a selective and potent Adenosine A2B-R inverse agonist Ki (binding affinity) values of 1.39, 157, 112, and 230 nM for human A2B, A1, A2A, and A3 receptors, respectively.

Biological Activity

Potent and selective adenosine A 2B receptor inverse agonist (K i values are 1.39, 157, 112 and 230 nM for human A 2B , A 1 , A 2A and A 3 receptors respectively).

in vivo

MRS-1706 (1-10 μM; intracavernous injection; Ada^–/– mice) reduces the magnitude and duration of electrical field stimulation (EFS)-induced contraction of corpus cavernosal strips (CCSs) from sickle cell disease (SCD) transgenic mice and inhibits the level of cAMP^[2].

Animal Model:	Ada^–/– mice^[2]
Dosage:	1 and 10 μM
Administration:	Intracavernous injection
Result:	Inhibited A2BR signaling and reduced the magnitude and duration. Inhibited the level of cAMP.

References

[1] YONG-CHUL KIM. Anilide Derivatives of an 8-Phenylxanthine Carboxylic Congener Are Highly Potent and Selective Antagonists at Human A2B Adenosine Receptors[J]. Journal of Medicinal Chemistry, 2000, 43 6: 1165-1172. DOI: 10.1021/jm990421v
[2] QILAN LI. ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor.[J]. Journal of Pharmacology and Experimental Therapeutics, 2007, 320 2: 637-645. DOI: 10.1124/jpet.106.111203

MRS 1706 Preparation Products And Raw materials

Raw materials

Preparation Products

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MRS 1706 Suppliers

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264622-53-9, MRS 1706Related Search:

2-(4-ETHOXY-PHENYL)-1H-IMIDAZOLE 1,3-DIPROPYL-8-PHENYLXANTHINE 8-PHENYLTHEOPHYLLINE MRS 1706 1,3-DIETHYL-8-PHENYLXANTHINE

MRS-1706;MRS 1706;MRS1706

N-(4-ACETYLPHENYL)-2-[4-(2,3,6,7-TETRAHYDRO-2,6-DIOXO-1,3-DIPROPYL-1H-PURIN-8-YL)PHENOXY]ACETAMIDE

MRS 1706

N-(4-acetylphenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide

Acetamide, N-(4-acetylphenyl)-2-[4-(2,3,6,9-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-

N-(4-Acetylphenyl)-2-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,9-tetrahydro-1H-purin-8-yl)phenoxy)acetamide

MRS-1706,cAMP,P1 receptor,corpus cavernosal strips,duration,inhibit,MRS 1706,Adenosine Receptor,MRS1706,Inhibitor,adenosine,magnitude

MRS-1706, 10 mM in DMSO

264622-53-9

C27H29N5O5