4-AMINOMETHYLPHENYLBORONIC ACID HYDROCHLORIDE
- Product Name
- 4-AMINOMETHYLPHENYLBORONIC ACID HYDROCHLORIDE
- CAS No.
- 75705-21-4
- Chemical Name
- 4-AMINOMETHYLPHENYLBORONIC ACID HYDROCHLORIDE
- Synonyms
- TIMTEC-BB SBB003689;4-Boronobenzylamine, HCl;4-AMINOMETHYLPHENYLBORONIC ACID HCL;4-AMINOMETHYLPHENYLBORONIC ACID, HYDROCH;4-AMINOMETHYLPHENYLBORONIC ACID HYDROCHLORIDE;4-AMINOMETHYLBENZENEBORONIC ACID HYDROCHLORIDE;4-AMINOMETHYLPHENYLBORONIC ACID HYDROCHLORIDE 96%;4-Aminomethylphenylboronic acid hydrochloride,96%;4-Aminomethylphenylboronic acid, hydrogen chloride;4-(Aminomethyl)benzeneboronic acid hydrochloride 97%
- CBNumber
- CB7411085
- Molecular Formula
- C7H11BClNO2
- Formula Weight
- 187.43
- MOL File
- 75705-21-4.mol
4-AMINOMETHYLPHENYLBORONIC ACID HYDROCHLORIDE Property
- Melting point:
- 240-250
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- DMSO (Sparingly), Methanol (Slightly)
- form
- Powder
- color
- Pale yellow
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C7H10BNO2.ClH/c9-5-6-1-3-7(4-2-6)8(10)11;/h1-4,10-11H,5,9H2;1H
- InChIKey
- HUZNRXFJHYNUMV-UHFFFAOYSA-N
- SMILES
- C1(B(O)O)=CC=C(CN)C=C1.Cl
- CAS DataBase Reference
- 75705-21-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 37/39-26
- WGK Germany
- WGK 3
- HazardClass
- IRRITANT
- HS Code
- 29310095
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Acute Tox. 4 Oral
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A614495
- Product name
- 4-Aminomethylphenylboronicacid,hydrochloride
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- A614495
- Product name
- 4-Aminomethylphenylboronicacid,hydrochloride
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- OR10330
- Product name
- 4-(Aminomethyl)benzeneboronicacidhydrochloride
- Purity
- 95%
- Packaging
- 250mg
- Price
- $22
- Updated
- 2021/12/16
- Product number
- 8660-5-X5
- Product name
- 4-(Aminomethyl)benzeneboronic acid hydrochloride
- Purity
- 97%
- Packaging
- 250mg
- Price
- $24
- Updated
- 2021/12/16
- Product number
- OR10330
- Product name
- 4-(Aminomethyl)benzeneboronicacidhydrochloride
- Purity
- 95%
- Packaging
- 1g
- Price
- $44
- Updated
- 2021/12/16
4-AMINOMETHYLPHENYLBORONIC ACID HYDROCHLORIDE Chemical Properties,Usage,Production
Chemical Properties
pale yellow powder
Uses
4-Aminomethylphenylboronic acid HCl is the salt form of A292475.
Synthesis
Step 1: To the reaction flask, add, in order, 160mL of water, 80mL of methanol, 10g of tert-butyl carbamate (85.36mmol), 30.4g of sodium p-toluenesulfinate (170.72mmol), 12.8g of 4-formylphenylboronic acid (85.36 mmol) and 6.5 mL of formic acid were reacted at room temperature for 36 h. The crude product was obtained by filtration, washed with water, washed with methyl tert-butyl ether and dried to obtain a white solid. Then the white solid as well as 600mL THF was added into the reaction flask, stirring was turned on to add 99.5g of potassium carbonate (720mmol), heated to 60??C for 15h, after cooling, filtered through diatomaceous earth, concentrated and evaporated the solvent to obtain 15.14g of imine intermediate, yield 71.2%;
Step 2: 15.14g of imine intermediate (60.78 mmol) was dissolved in 150 mL of methanol, 4.6 g of NaBH4 (121.56 mmol) was added in batches, the reaction was carried out at room temperature overnight, and the reduced intermediate was concentrated under reduced pressure. The reduced intermediate was adjusted to pH=5-6 with 1.0M aqueous citric acid, extracted with ethyl acetate, and the organic phase was washed with water and dried to obtain 4-(N-Boc-aminomethyl)phenylboronic acid.
Step 3: 4-(N-Boc-aminomethyl)phenylboronic acid was added to the reaction flask, followed by adding 100mL 3.0M HCl/ethyl acetate solution (), stirring at room temperature for 2h, and filtration to obtain 10.18g of 4-aminomethylphenylboronic acid hydrochloride, yield 89.4%.4-AMINOMETHYLPHENYLBORONIC ACID HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-AMINOMETHYLPHENYLBORONIC ACID HYDROCHLORIDE manufacturers
- Product
- 4-Aminomethylphenylboronicacidhydrochloride 75705-21-4
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-07-04
- Product
- 4-AMINOMETHYLPHENYLBORONIC ACID HYDROCHLORIDE 75705-21-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 200kg
- Release date
- 2019-08-30