ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate
- Product Name
- ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate
- CAS No.
- 371924-24-2
- Chemical Name
- ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate
- Synonyms
- Ethyl 4-((4-(diethylamino)phenyl)amino)-6-methylquinoline-3-carboxylate;ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate;3-Quinolinecarboxylic acid, 4-[[4-(diethylamino)phenyl]amino]-6-methyl-, ethyl ester;C2C12,Inhibitor,mitochondrial,MCU-i-4,Mitochondrial Metabolism,MCU-i4,MCUi4,Ca2+,uptake,inhibit,MCU i4,myoblast
- CBNumber
- CB74119266
- Molecular Formula
- C23H27N3O2
- Formula Weight
- 377.48
- MOL File
- 371924-24-2.mol
ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate Property
- Boiling point:
- 513.1±50.0 °C(Predicted)
- Density
- 1.163±0.06 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- solubility
- DMSO:18.87(Max Conc. mg/mL);50.0(Max Conc. mM)
Ethanol:37.75(Max Conc. mg/mL);100.0(Max Conc. mM) - form
- Solid
- pka
- 7.21±0.44(Predicted)
- color
- White to yellow
N-Bromosuccinimide Price
- Product number
- CS-0159538
- Product name
- MCU-i4
- Packaging
- 10mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- CS-0159538
- Product name
- MCU-i4
- Packaging
- 25mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CS-0159538
- Product name
- MCU-i4
- Packaging
- 50mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- CS-0159538
- Product name
- MCU-i4
- Packaging
- 100mg
- Price
- $400
- Updated
- 2021/12/16
- Product number
- A1445645
- Product name
- Ethyl4-((4-(diethylamino)phenyl)amino)-6-methylquinoline-3-carboxylate
- Purity
- 98+%
- Packaging
- 100mg
- Price
- $366
- Updated
- 2021/12/16
ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate Chemical Properties,Usage,Production
Biological Activity
MCU-i4 blocks the IP3-dependent mitochondrial Ca2+-uptake, maintaining the gatekeeping role of their target[1][2]. MCU-i4 modulates mitochondrial Ca2+ uptake to 1 min of incubation, i.e., exerting a negative modulation, indicating that the primary effect of these compounds is a sudden and direct modulation of MCU complex activity[1].MCU-i4 exerted a negative effect on δψ. MCU-i4 has no effect on cell viability[1]. Cell Differentiation Assay[1] Cell Line: Growing medium of 90% confluent C2C12 myoblasts.
storage
Store at -20°C
References
[1]. Giulia Di Marco, et al. A High-Throughput Screening Identifies MICU1 Targeting Compounds. Cell Rep. 2020 Feb 18;30(7):2321-2331.e6. [2]. Alessandro Rimessi, et al. Update on Calcium Signaling in Cystic Fibrosis Lung Disease. Front Pharmacol. 2021 Mar 11;12:581645.
ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate Preparation Products And Raw materials
Raw materials
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