ChemicalBook > CAS DataBase List > SLV-2436

SLV-2436

Product Name
SLV-2436
CAS No.
2095704-43-9
Chemical Name
SLV-2436
Synonyms
V-2436;SEL-201;SLV-2436;SEL201-88;SEL201 ，S6888;SLV-2436, 10 mM in DMSO;5-(3-Amino-1H-indazol-6-yl)-1-(3-chlorob...;5-(3-amino-1H-indazol-6-yl)-1-(3-chlorobenzyl)pyridin-2(1H)-one;5-(3-Amino-1H-indazol-6-yl)-1-[(3-chlorophenyl)methyl]-2(1H)-pyridinone;2(1H)-Pyridinone, 5-(3-amino-1H-indazol-6-yl)-1-[(3-chlorophenyl)methyl]-
CBNumber
CB74187995
Molecular Formula
C19H15ClN4O
Formula Weight
350.8
MOL File
2095704-43-9.mol
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SLV-2436 Property

storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 100 mg/mL (285.06 mM)
form 
Solid
color 
Light brown to brown
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0043363
Product name
SLV-2436
Purity
98.47%
Packaging
5mg
Price
$220
Updated
2021/12/16
ChemScene
Product number
CS-0043363
Product name
SLV-2436
Purity
98.47%
Packaging
10mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0043363
Product name
SLV-2436
Purity
98.47%
Packaging
50mg
Price
$1100
Updated
2021/12/16
ChemScene
Product number
CS-0043363
Product name
SLV-2436
Purity
98.47%
Packaging
100mg
Price
$1600
Updated
2021/12/16
DC Chemicals
Product number
DC21661
Product name
SEL-201
Purity
>98%
Packaging
1g
Price
$2200
Updated
2021/12/16
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SLV-2436 Chemical Properties,Usage,Production

Uses

SLV-2436 is a highly potent and ATP-competitive inhibitor of MNK1 and MNK2 with IC50s of 10.8 nM and 5.4 nM, respectively.

in vivo

To investigate the pharmacodynamic properties of SLV-2436 (SEL201), 5 consecutive oral doses of 10, 25, and 50 mg/kg are administered to mice every 12 hours (twice-daily schedule). At the 10 mg/kg twice-daily dosage, 4 hours after the fifth administration, a low plasma concentration of 125 ng/mL SLV-2436 is determined. However, dosing at 25 and 50 mg/kg twice daily, equivalent to 50 and 100 mg/kg/d of SLV-2436, yields substantially increased dose-dependent plasma exposure, reaching an average level of 1,299 ng/mL and 2,075 ng/mL, respectively. At the 24-hour time point, SLV-2436 is still detectable in the plasma, with dose-dependent concentrations of 9, 73, and 124 ng/mL in the 10, 25, and 50 mg/kg twice-daily treatment groups. Oral (p.o.) administration of SLV-2436 at the dosage of 50 mg/kg twice daily, that is, 100 mg/kg/d, for 37 days is well tolerated in mice[1].

IC 50

MNK2: 5.4 nM (IC50); MNK1: 10.8 nM (IC50)

References

[1] Zhan Y, et al. MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma. J Clin Invest. 2017 Nov 1;127(11):4179-4192. DOI:10.1172/JCI91258

SLV-2436 Preparation Products And Raw materials

Raw materials

Preparation Products

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SLV-2436 Suppliers

China 48 United States 4 Global 52
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
8011
Advantage
55
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9126
Advantage
58
Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
12476
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Medi-tech Bioscientific Co., Ltd.
Tel
0519-83246372 13585352506
Fax
0519-83246372
Country
China
ProdList
1844
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58
Twochem Co.Ltd.
Tel
021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
1788
Advantage
58
Tianjin Kaifu Pharmaceutical Technology Co., Ltd.
Tel
18081075745
Email
chemflowtech@sina.com
Country
China
ProdList
1886
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58

2095704-43-9, SLV-2436Related Search:

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  • 5-(3-amino-1H-indazol-6-yl)-1-(3-chlorobenzyl)pyridin-2(1H)-one
  • SLV-2436, 10 mM in DMSO
  • SEL201 ，S6888
  • 5-(3-Amino-1H-indazol-6-yl)-1-[(3-chlorophenyl)methyl]-2(1H)-pyridinone
  • 2095704-43-9