2-IODO-4-TRIFLUOROMETHYL-BENZOIC ACID
- Product Name
- 2-IODO-4-TRIFLUOROMETHYL-BENZOIC ACID
- CAS No.
- 54507-44-7
- Chemical Name
- 2-IODO-4-TRIFLUOROMETHYL-BENZOIC ACID
- Synonyms
- BUTTPARK 83\07-35;2-IODO-4-TRIFLUOROMETHYL-BENZOIC ACID;2-Iodo-4-(trifluoromethyl)benzoicacid97%;2-Iodo-4-(trifluoromethyl)benzoicacid,98%;Benzoic acid, 2-iodo-4-(trifluoromethyl)-;2-Iodo-4-(trifluoromethyl)benzoic acid 97%;4-Carboxy-3-iodobenzotrifluoride, 2-Iodo-alpha,alpha,alpha-trifluoro-p-toluic acid
- CBNumber
- CB7419586
- Molecular Formula
- C8H4F3IO2
- Formula Weight
- 316.02
- MOL File
- 54507-44-7.mol
2-IODO-4-TRIFLUOROMETHYL-BENZOIC ACID Property
- Boiling point:
- 300.8±42.0 °C(Predicted)
- Density
- 2.005±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Slightly soluble.
- pka
- 2.35±0.10(Predicted)
- form
- solid
- color
- Faint brown
- Sensitive
- Light Sensitive
Safety
- HS Code
- 2916310090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- PC49379
- Product name
- 2-Iodo-4-(trifluoromethyl)benzoicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $41
- Updated
- 2021/12/16
- Product number
- 2821-K-01
- Product name
- 2-Iodo-4-(trifluoromethyl)benzoic acid?
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC49379
- Product name
- 2-Iodo-4-(trifluoromethyl)benzoicacid
- Purity
- 97%
- Packaging
- 5g
- Price
- $182
- Updated
- 2021/12/16
- Product number
- 2821-K-01
- Product name
- 2-Iodo-4-(trifluoromethyl)benzoic acid?
- Packaging
- 5G
- Price
- $200
- Updated
- 2021/12/16
- Product number
- W6873
- Product name
- 2-Iodo-4-(trifluoromethyl)benzoicacid
- Packaging
- 5g
- Price
- $274
- Updated
- 2021/12/16
2-IODO-4-TRIFLUOROMETHYL-BENZOIC ACID Chemical Properties,Usage,Production
Uses
The 10-chloro-8-fluoro-10, 11-dihydro-2-trifluoromethyldibenzothiepin used as the starting material can be prepared starting from 2-iodo--4-trifluoromethyl-benzoic acid and 4-fluoro-thiophenol.
Synthesis
402-13-1
54507-44-7
3) Synthesis of 2-iodo-4-(trifluoromethyl)benzoic acid (Compound 211-3) [0356] 2-Amino-4-(trifluoromethyl)benzoic acid (25.0 g) was dissolved in a dilute sulfuric acid solution prepared from concentrated sulfuric acid (60 ml dropwise at 0°C) and water (600 ml). Subsequently, an aqueous sodium nitrite solution prepared from sodium nitrite (12.4 g) and water (60 ml) was added for the diazotization reaction. An aqueous solution of potassium iodide prepared from potassium iodide (30.0 g) and water (60 ml) was added dropwise to the reaction system, and then the mixture was gradually heated to 80 °C and stirred at that temperature for 1 hour. After completion of the reaction, the reaction mixture was cooled and 2% aqueous sodium thiosulfate solution was added to quench the reaction and stirred for some time. The precipitated solid was collected by filtration to give the crude product (30.5 g). The above steps were repeated to obtain crude product (22.0 g) from another batch of 2-amino-4-(trifluoromethyl)benzoic acid (25.0 g). The solid products obtained from the two combinations were purified by silica gel column chromatography to give the final compound 211-3 (39.5 g) as a light yellow solid. The product was characterized by 1H-NMR (DMSO-d6) with the following chemical shift δ (ppm): 7.82-7.90 (2H, m), 8.27 (1H, s), 13.8 (1H, brs).
References
[1] RSC Advances, 2013, vol. 3, # 38, p. 17271 - 17280
[2] Patent: EP2842937, 2015, A1. Location in patent: Paragraph 0356-0357
[3] Journal of Organic Chemistry, 2017, vol. 82, # 4, p. 2263 - 2268
[4] Organic Letters, 2017, vol. 19, # 7, p. 1578 - 1581
2-IODO-4-TRIFLUOROMETHYL-BENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-IODO-4-TRIFLUOROMETHYL-BENZOIC ACID manufacturers
- Product
- 2-IODO-4-TRIFLUOROMETHYL-BENZOIC ACID 54507-44-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11