ChemicalBook > CAS DataBase List > MMP-9/MMP-13 INHIBITOR I

MMP-9/MMP-13 INHIBITOR I

Product Name
MMP-9/MMP-13 INHIBITOR I
CAS No.
204140-01-2
Chemical Name
MMP-9/MMP-13 INHIBITOR I
Synonyms
MMP-9/MMP-13 INHIBITOR I;MMP-9/MMP-13 INHIBITOR II;MMP-9/MMP-13 Inhibitor I - CAS 204140-01-2 - Calbiochem[444252];N-HYDROXY-1-(4-METHOXYPHENYL)SULFONYL-4-BENZYLOXYCARBONYLPIPERAZINE-2-CARBOXAMIDE;N-HYDROXY-1-(4-METHOXYPHENYL)SULFONYL-4-(4-BIPHENYLCARBONYL)PIPERAZINE-2-CARBOXAMIDE;2-Piperazinecarboxamide, 4-([1,1'-biphenyl]-4-ylcarbonyl)-N-hydroxy-1-[(4-methoxyphenyl)sulfonyl]-
CBNumber
CB7427176
Molecular Formula
C25H25N3O6S
Formula Weight
495.55
MOL File
Mol file
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MMP-9/MMP-13 INHIBITOR I Property

Density 
1.364±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO or methanol
pka
9.38±0.23(Predicted)
form 
Solid
color 
White to off-white
Sensitive 
Light Sensitive
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
444252
Product name
MMP-9/MMP-13 Inhibitor I - CAS 204140-01-2 - Calbiochem
Packaging
1MG
Price
$139
Updated
2025/07/31
Cayman Chemical
Product number
21265
Product name
MMP-9/MMP-13 Inhibitor I
Purity
≥98%
Packaging
500μg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
21265
Product name
MMP-9/MMP-13 Inhibitor I
Purity
≥98%
Packaging
1mg
Price
$130
Updated
2024/03/01
AK Scientific
Product number
4664CR
Product name
MMP-9/MMP-13 Inhibitor I
Packaging
1mg
Price
$241
Updated
2021/12/16
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MMP-9/MMP-13 INHIBITOR I Chemical Properties,Usage,Production

Description

MMP-9/MMP-13 inhibitor I is a cell-permeable inhibitor of matrix metalloproteinases (MMPs) that most potently inhibits MMP-9 and MMP-13 (IC50s = 0.9 nM for both). It less effectively inhibits MMP-1, MMP-3, and MMP-7 (IC50s = 43, 23, and 920 nM, respectively). MMP-9/MMP-13 inhibitor I has been used to elucidate the roles of MMPs in biological systems, including tumor cell invasion and pathogenesis of P. falciparum.

Uses

A piperazine-based, cell-permeable, and highly potent inhibitor of MMP-9 and MMP-13

IC 50

MMP-9: 0.9 nM (IC50); MMP-13: 0.9 nM (IC50); MMP-1: 43 nM (IC50); MMP-3: 23 nM (IC50); MMP-7: 931 nM (IC50)

References

[1] MENYAN CHENG. Design and Synthesis of Piperazine-Based Matrix Metalloproteinase Inhibitors[J]. Journal of Medicinal Chemistry, 2000, 43 3: 369-380. DOI: 10.1021/jm990366q
[2] MAURO PRATO. Phagocytosis of hemozoin enhances matrix metalloproteinase-9 activity and TNF-alpha production in human monocytes: role of matrix metalloproteinases in the pathogenesis of falciparum malaria.[J]. Journal of immunology, 2005, 175 10: 6436-6442. DOI: 10.4049/jimmunol.175.10.6436
[3] PETER STORZ. FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases.[J]. Molecular and Cellular Biology, 2009, 29 18: 4906-4917. DOI: 10.1128/mcb.00077-09
[4] MUTHULEKHA SWAMYDAS. Mesenchymal stem cell-derived CCL-9 and CCL-5 promote mammary tumor cell invasion and the activation of matrix metalloproteinases.[J]. Cell Adhesion & Migration, 2013, 7 3: 315-324. DOI: 10.4161/cam.25138

MMP-9/MMP-13 INHIBITOR I Preparation Products And Raw materials

Raw materials

Preparation Products

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MMP-9/MMP-13 INHIBITOR I Suppliers

China 16 Japan 1 United Kingdom 1 United States 6 Global 24
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
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510
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64
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
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58
Alabiotech Inc.
Tel
001-619-354-5251
Fax
001-855-855-6087
Email
sales@alabiotech-e.com
Country
United States
ProdList
972
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60
Alpha Biopharmaceuticals Co., Ltd
Tel
0411-39042497
Fax
0411-39042693
Email
sales@alphabiopharm.com
Country
China
ProdList
1951
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58
Nextpeptide Inc
Tel
+86-0571-81612335 +8613336028439
Email
sales@nextpeptide.com
Country
China
ProdList
19908
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58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
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58
Nantong Hanfang Biotechnology Co. , Ltd.
Tel
hanfangpharma@126.com; 18616537568
Email
hanfangpharma@126.com
Country
China
ProdList
29965
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58
Cayman Chemical Company
Tel
800-364-9897
Email
sales@caymanchem.com
Country
China
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6838
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58
Merck KGaA
Tel
21-20338288
Email
ordercn@merckgroup.com
Country
China
ProdList
6394
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Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
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6594
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204140-01-2, MMP-9/MMP-13 INHIBITOR IRelated Search:


  • MMP-9/MMP-13 INHIBITOR I
  • MMP-9/MMP-13 INHIBITOR II
  • N-HYDROXY-1-(4-METHOXYPHENYL)SULFONYL-4-(4-BIPHENYLCARBONYL)PIPERAZINE-2-CARBOXAMIDE
  • N-HYDROXY-1-(4-METHOXYPHENYL)SULFONYL-4-BENZYLOXYCARBONYLPIPERAZINE-2-CARBOXAMIDE
  • 2-Piperazinecarboxamide, 4-([1,1'-biphenyl]-4-ylcarbonyl)-N-hydroxy-1-[(4-methoxyphenyl)sulfonyl]-
  • MMP-9/MMP-13 Inhibitor I - CAS 204140-01-2 - Calbiochem[444252]
  • 204140-01-2