CLOZAPINE-D3

Product Name: CLOZAPINE-D3
CAS No.: 1215691-72-7
Chemical Name: CLOZAPINE-D3
Synonyms: CLOZAPINE-D3;[2H3]-Clozapine;QZUDBNBUXVUHMW-FIBGUPNXSA-N;Clozapine-d3 Discontined. Please see C587502
CBNumber: CB7437795
Molecular Formula: C18H19ClN4
Formula Weight: 326.83
MOL File: 1215691-72-7.mol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: RDL0006731
Product name: CLOZAPINE-D3
Purity: 95.00%
Packaging: 5MG
Price: $497.75
Updated: 2021/12/16

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CLOZAPINE-D3 Chemical Properties,Usage,Production

Uses

Clozapine-d3 (HF 1854-d3) is deuterium labeled Clozapine. Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively[1][2][3]. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM)[1][2][3][4][5].

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Seeman P, et al. Clozapine, a fast-off-D2 antipsychotic. ACS Chem Neurosci. 2014 Jan 15;5(1):24-9. DOI:10.1021/cn400189s
[3] Zorn SH, et al. Clozapine is a potent and selective muscarinic M4 receptor agonist. Eur J Pharmacol. 1994 Nov 15;269(3):R1-2. DOI:10.1016/0922-4106(94)90047-7
[4] Zhukovskaya NL, et al. Clozapine downregulates 5-hydroxytryptamine6 (5-HT6) and upregulates 5-HT7 receptors in HeLa cells. Neurosci Lett. 2000 Jul 21;288(3):236-40. DOI:10.1016/s0304-3940(00)01225-8
[5] Moreno JL, et al. Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice. Psychopharmacology (Berl). 2013 Jan;225(1):217-26. DOI:10.1007/s00213-012-2809-7

CLOZAPINE-D3 Preparation Products And Raw materials

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CLOZAPINE-D3 Suppliers

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1215691-72-7, CLOZAPINE-D3Related Search:

Risperidone Clozapine

CLOZAPINE-D3

QZUDBNBUXVUHMW-FIBGUPNXSA-N

[2H3]-Clozapine

Clozapine-d3 Discontined. Please see C587502

1215691-72-7

C18H16D3ClN4