Chemical properties Uses Production Content analysis Toxicity
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Triacetin

Chemical properties Uses Production Content analysis Toxicity
Product Name
Triacetin
CAS No.
102-76-1
Chemical Name
Triacetin
Synonyms
Vanay;Glyped;Enzactin;FEMA 2007;TRIACETIN;tri-aceti;Triaeetin;triacetate;Fungacetin;Triacetine
CBNumber
CB7441695
Molecular Formula
C9H14O6
Formula Weight
218.2
MOL File
102-76-1.mol
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Triacetin Property

Melting point:
3 °C(lit.)
Boiling point:
258-260 °C(lit.)
Density 
1.16 g/mL at 25 °C(lit.)
vapor density 
7.52 (vs air)
vapor pressure 
0.00248 mm Hg @ 250C
FEMA 
2007 | (TRI-)ACETIN
refractive index 
n25/D 1.429-1.431(lit.)
Flash point:
300 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
Soluble in water, miscible with ethanol (96 per cent) and toluene.
form 
Liquid
color 
Clear colorless
Odor
Characteristic odour
explosive limit
1.05%, 189°F
Water Solubility 
64.0 g/L (20 ºC)
JECFA Number
920
Merck 
14,9589
BRN 
1792353
Stability:
Stable. Incompatible with strong oxidizing agents. Combustible.
InChIKey
URAYPUMNDPQOKB-UHFFFAOYSA-N
CAS DataBase Reference
102-76-1(CAS DataBase Reference)
NIST Chemistry Reference
1,2,3-Propanetriol, triacetate(102-76-1)
EPA Substance Registry System
Glyceryl triacetate (102-76-1)
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Safety

Safety Statements 
23-24/25
WGK Germany 
1
RTECS 
AK3675000
Autoignition Temperature
809 °F
TSCA 
Yes
HS Code 
29153930
Hazardous Substances Data
102-76-1(Hazardous Substances Data)
Toxicity
LD50 i.v. in mice: 1600 ±81 mg/kg (Wretlind)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W200700
Product name
Triacetin
Purity
99%, FCC, FG
Packaging
1 kg
Price
$70
Updated
2021/03/22
Sigma-Aldrich
Product number
525073
Product name
Triacetin
Purity
99%
Packaging
1l
Price
$81.5
Updated
2021/03/22
Sigma-Aldrich
Product number
1.03000
Product name
Triacetin
Purity
EMPROVE? ESSENTIAL Ph Eur,BP,USP
Packaging
1 L
Price
$88.6
Updated
2021/03/22
Sigma-Aldrich
Product number
W200700
Product name
Triacetin
Purity
99%, FCC, FG
Packaging
10 kg
Price
$126
Updated
2021/03/22
Sigma-Aldrich
Product number
1675007
Product name
Triacetin
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
1g
Price
$366
Updated
2021/03/22
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Triacetin Chemical Properties,Usage,Production

Chemical properties

Colorless, odorless oily liquid. It is miscible with ethanol, ether, benzene, chloroform and other organic solvents, soluble in acetone, insoluble in mineral oil. Slightly soluble in water. 25 ° C in water solubility of 5.9g / 100ml.

Uses

  • As a plasticizer and fragrance fixative, ink solvent, also used in medicine and dye synthesis.
  • As a chromatographic fixative, solvent, toughener and fragrance fixative.
  • Humectants; carrier solvents; plasticizers; it can absorb carbon dioxide from the natural gas.
  • In the production of cosmetics, pharmaceuticals and dyes, plasticizers for cigarette filter rods, and so on.
  • Applied in cosmetics, casting, medicine, dyes and other industries. This product is non-toxic, non-irritating.
  • As the substrate for the determination of lipase, perfume fixative, solvent, gas chromatographic fixative (maximum temperature of 85 ℃, solvent: methanol, chloroform), separation of gas and aldehyde analysis.

Production

It can be derived from the esterification of glycerol and acetic acid. After preheating glycerol to 50-60 ° C, add acetic acid, benzene and sulfuric acid. Heat and stir for refluxing dehydration, and recycle the benzene. Then add acetic anhydride for heating of 4h. After cooling, the mixture was neutralized with 5% sodium carbonate to pH 7, and the crude layer was dried and the crude oil was dried with calcium chloride. Distill under reduced pressure, collect the 128-131 ° C (0.93 kPa) fraction, namely glycerol triacetate.

Content analysis

Accurately weigh about 1g of the sample, put it into a suitable pressure bottle, add 25 mL of 1mol / L. potassium hydroxide solution and 15 mL of isopropyl alcohol, add stopper, wrap with cloth and put it in a canvas bag. Put it into the water bath of 98 ℃ ± 2 ℃ for 1h, and the water level in the water bath should be slightly higher than the bottle level. Take the bottle out from the bag, cool it to room temperature in the air, unfold the cloth and stopper to release the residual pressure in the bottle, and then remove the cloth. Add 6 to 8 drops of phenolphthalein test solution (TS-167), apply 0.5mol / L sulfuric acid for titration of excess alkali until the pink could just disappeared. At the same time, perform a blank test. Each mL of 0.5mol / L sulfuric acid is equivalent to 36.37 mg of glyceryl triacetate (C9H14O6).

Toxicity

ADI is not subject to special provisions (FAO / WHO, 2001).
GR.AS (FDA, § 182.1901, 2000).
LD50 3000mg / kg (rat, oral).

Description

§ 184.1901(a) Triacetin (C8H14O6), also known as 1,2,3-propanetriol triacetate or glyceryl triacetate, is the triester of glycerin and acetic acid. Triacetin can be prepared by heating glycerin with acetic anhydride alone or in the presence of finely divided potassium hydrogen sulfate. It can also be prepared by the reaction of oxygen with a liquid-phase mixture of allyl acetate and acetic acid using a bromide salt as a catalyst.

Chemical Properties

Triacetin has a very faint, fruity odor. It has a mild, sweet taste that is bitter above 0.05%.

Chemical Properties

Colorless liquid; slight fatty odor; bitter taste. Slightly soluble in water; very soluble in alcohol, ether, and other organic solvents. Combustible.

Chemical Properties

Triacetin is a colorless, viscous liquid with a slightly fatty odor.

Originator

Enzactin,Ayerst,US,1957

Occurrence

Reported found in papaya.

Uses

Triacetin, a component of cigarette filters, induced a contact dermatitis in a worker at a cigarette manufacturers.

Uses

Triacetin is a colorless, oily liquid of slight fatty odor and bitter taste. It is soluble with water and is miscible with alcohol and ether. It functions in foods as a humectant and solvent.

Uses

As fixative in perfumery; solvent in manufacture of celluloid, photographic films. Technical triacetin (a mixture of mono-, di-, and small quantities of triacetin) as a solvent for basic dyes, particularly indulines, and tannin in dyeing.

Definition

ChEBI: A triglyceride obtained by acetylation of the three hydroxy groups of glycerol. It has fungistatic properties (based on release of acetic acid) and has been used in the topical treatment of minor dermatophyte infections.

Production Methods

Triacetin is prepared by the esterification of glycerin with acetic anhydride.

Preparation

By direct reaction of glycerol with acetic acid in the presence of Twitchell’s reagent, or in benzene solution of glycerol and boiling acetic acid in the presence of a cationic resin (Zeo-Karb H) pretreated with dilute H2SO4.

Manufacturing Process

200 grams of allyl acetate, 450 grams of glacial acetic acid and 3.71 grams of cobaltous bromide were charged to the reactor and the mixture was heated to 100°C. Pure oxygen was then introduced into the reactor below the surface of the liquid reaction mixture at the rate of 0.5 standard cubic feet per hour. Initially, all of the oxygen was consumed, but after a period of time oxygen introduced into the mixture passed through unchanged. During the course of the reaction, a small quantity of gaseous hydrogen bromide (a total of 1.9 grams) was introduced into the reaction zone, along with the oxygen. The reaction was allowed to continue for 6 hours following which the reaction mixture was distilled. Essentially complete conversion of the allyl acetate took place. A yield of 116 grams of glycerol triacetate was obtained, this being accomplished by distilling the glycerol triacetate overhead from the reaction mixture, at an absolute pressure of approximately 13 mm of mercury.

Therapeutic Function

Topical antifungal

Taste threshold values

Sweet and creamy with an oily mouthfeel.

Pharmaceutical Applications

Triacetin is mainly used as a hydrophilic plasticizer in both aqueous and solvent-based polymeric coating of capsules, tablets, beads, and granules; typical concentrations used are 10–35% w/w.
Triacetin is used in cosmetics, perfumery, and foods as a solvent and as a fixative in the formulation of perfumes and flavors.

Contact allergens

Triacetin is a component of cigarette filters, which induced a contact dermatitis in a worker at a cigarette manufactory.

Clinical Use

Glyceryl triacetate (Enzactin, Fungacetin) is a colorless, oilyliquid with a slight odor and a bitter taste. The compound issoluble in water and miscible with alcohol and most organicsolvents.
The activity of triacetin is a result of the acetic acid releasedby hydrolysis of the compound by esterases presentin the skin. Acid release is a self-limiting process becausethe esterases are inhibited below pH 4.

Safety Profile

Poison by ingestion. Moderately toxic by intraperitoneal, subcutaneous, and intravenous routes. An eye irritant. Combustible when exposed to heat, flame, or powerful oxidizers. To fight fire, use alcohol foam, water, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.

Safety

Triacetin is used in oral pharmaceutical formulations and is generally regarded as a relatively nontoxic and nonirritant material at the levels employed as an excipient.
LD50 (dog, IV): 1.5 g/kg
LD50 (mouse, IP): 1.4 g/kg
LD50 (mouse, IV): 1.6 g/kg
LD50 (mouse, oral): 1.1 g/kg
LD50 (mouse, SC): 2.3 g/kg
LD50 (rabbit, IV): 0.75 g/kg
LD50 (rat, IP): 2.1 g/kg
LD50 (rat, oral): 3 g/kg
LD50 (rat, SC): 2.8 g/kg

storage

Triacetin is stable and should be stored in a well-closed, nonmetallic container, in a cool, dry place.

Incompatibilities

Triacetin is incompatible with metals and may react with oxidizing agents. Triacetin may destroy rayon fabric.

Regulatory Status

GRAS listed. Accepted in Europe as a food additive in certain applications. Included in the FDA Inactive Ingredients Database (oral capsules and tablets and gels). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Triacetin Preparation Products And Raw materials

Raw materials

Preparation Products

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Triacetin Suppliers

YIXING TIANYUAN CHEMICAL CO.,LTD.
Tel
0510-87551598-
Email
yxty@tychemicals.com
Country
China
ProdList
1
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Spectrum Chemical Manufacturing Corp.
Tel
021-67601398-809
Fax
021-57711696
Email
marketing_china@spectrumchemical.com;
Country
China
ProdList
9686
Advantage
60
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
021-20337333-801
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
24980
Advantage
65
Jobachem Suzhou Co., Ltd
Tel
0512-62927368
Email
xiaomin.cheng@jobachem.com;jing.ding@jobachem.com
Country
China
ProdList
44
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
Energy Chemical
Tel
021-58432009-
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
43503
Advantage
61
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078;021-50426030
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
10006
Advantage
60
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View Lastest Price from Triacetin manufacturers

Shanxi Lianxu New Material Co., LTD
Product
Triacetin 102-76-1
Price
US $100.00/Kg/Drum
Min. Order
1Kg/Drum
Purity
99%
Supply Ability
1000kg/month
Release date
2021-11-04
Hebei Crovell Biotech Co Ltd
Product
Triacetin 102-76-1
Price
US $8.00/KG/Tin
Min. Order
10g
Purity
99 %
Supply Ability
10000kg
Release date
2021-06-25
Wuhan Mulei New Material Technology Co. Ltd
Product
Triacetin 102-76-1
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99.9%
Supply Ability
100000kg per month
Release date
2021-03-31

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