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(4-NITRO-PYRAZOL-1-YL)-ACETIC ACID

Product Name
(4-NITRO-PYRAZOL-1-YL)-ACETIC ACID
CAS No.
6645-69-8
Chemical Name
(4-NITRO-PYRAZOL-1-YL)-ACETIC ACID
Synonyms
AKOS B000219;AKOS PAO-0916;CHEMBRDG-BB 5913009;ART-CHEM-BB B000219;TIMTEC-BB SBB000166;2-(4-nitropyrazol-1-yl)acetic acid;2-(4-nitro-1-pyrazolyl)acetic acid;(4-NITRO-PYRAZOL-1-YL)-ACETIC ACID;1H-Pyrazole-1-acetic acid, 4-nitro-;(4-NITRO-1H-PYRAZOL-1-YL)ACETIC ACID
CBNumber
CB7447006
Molecular Formula
C5H5N3O4
Formula Weight
171.11
MOL File
6645-69-8.mol
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(4-NITRO-PYRAZOL-1-YL)-ACETIC ACID Property

Boiling point:
416.4±25.0 °C(Predicted)
Density 
1.71±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
3.33±0.10(Predicted)
Appearance
White to light yellow Solid
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC
Product number
N497013
Product name
(4-Nitro-1H-pyrazol-1-yl)aceticAcid
Packaging
500mg
Price
$155
Updated
2021/12/16
Matrix Scientific
Product number
011061
Product name
(4-Nitro-pyrazol-1-yl)-acetic acid
Packaging
1g
Price
$229
Updated
2021/12/16
AK Scientific
Product number
7665AE
Product name
(4-Nitro-pyrazol-1-yl)-aceticacid
Packaging
250mg
Price
$84
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0102208
Product name
(4-NITRO-1H-PYRAZOL-1-YL)ACETIC ACID
Purity
95.00%
Packaging
1G
Price
$648.81
Updated
2021/12/16
Matrix Scientific
Product number
011061
Product name
(4-Nitro-pyrazol-1-yl)-acetic acid
Packaging
5g
Price
$744
Updated
2021/12/16
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(4-NITRO-PYRAZOL-1-YL)-ACETIC ACID Chemical Properties,Usage,Production

Uses

(4-Nitro-1H-pyrazol-1-yl)acetic Acid is used in pharmacological study of effects of C-nitropyrazoles and C-nitroazoles on ocular blood flow and retinal function recovery after ischemic insult.

Synthesis

2075-46-9

79-08-3

6645-69-8

An aqueous solution (100 mL) of potassium hydroxide (32.7 g, 0.58 mol) was slowly added to an acetone solution (500 mL) of 4-nitro-1H-pyrazole (30 g, 0.27 mol) under stirring at room temperature. After 30 minutes of reaction, an acetone solution (100 mL) of 2-bromoacetic acid (38.7 g, 0.27 mol) was added dropwise. The reaction mixture was continued to be stirred overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was diluted with water and extracted three times with ethyl acetate, the organic phases were combined and concentrated under reduced pressure. Subsequently, the residue was further extracted with a solvent mixture of dichloromethane and methanol, and the organic phases were combined and concentrated again under reduced pressure to give the target product 2-(4-nitro-1H-pyrazol-1-yl)acetic acid (40 g, 88% yield).

References

[1] Patent: WO2013/174895, 2013, A1. Location in patent: Page/Page column 70

(4-NITRO-PYRAZOL-1-YL)-ACETIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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(4-NITRO-PYRAZOL-1-YL)-ACETIC ACID Suppliers

China 23 Germany 2 India 1 Russia 3 Ukraine 2 United Kingdom 2 United States 6 Global 39
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Energy Chemical
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6645-69-8, (4-NITRO-PYRAZOL-1-YL)-ACETIC ACIDRelated Search:

(3-METHYL-4-NITRO-PYRAZOL-1-YL)-ACETIC ACID 2-METHYL-2-(4-NITRO-PYRAZOL-1-YL)-PROPIONIC ACID (5-METHYL-4-NITRO-PYRAZOL-1-YL)-ACETIC ACID 2-(3,5-DIMETHYL-4-NITRO-PYRAZOL-1-YL)-PROPIONIC ACID 2-METHYL-2-(4-NITRO-PYRAZOL-1-YL)-PROPIONIC ACID ETHYL ESTER (4-NITRO-PYRAZOL-1-YL)-ACETIC ACID (3,5-DIMETHYL-4-NITRO-PYRAZOL-1-YL)-ACETIC ACID 2-(3-METHOXY-4-NITRO-PYRAZOL-1-YL)-PROPIONIC ACID METHYL ESTER 2-(3,5-DIMETHYL-4-NITRO-PYRAZOL-1-YL)-PROPIONIC ACID ETHYL ESTER (3-METHOXY-4-NITRO-PYRAZOL-1-YL)-ACETIC ACID ETHYL ESTER (4-NITRO-PYRAZOL-1-YL)-ACETIC ACID ETHYL ESTER (5-METHYL-3-NITRO-PYRAZOL-1-YL)-ACETIC ACID (3-METHYL-4-NITRO-PYRAZOL-1-YL)-ACETIC ACID HYDRAZIDE (3-DIFLUOROMETHYL-5-METHYL-4-NITRO-PYRAZOL-1-YL)-ACETIC ACID (4-CHLORO-5-METHYL-3-NITRO-PYRAZOL-1-YL)-ACETIC ACID ETHYL ESTER (3,5-DIMETHYL-4-NITRO-PYRAZOL-1-YL)-ACETIC ACID HYDRAZIDE (3-NITRO-PYRAZOL-1-YL)-ACETIC ACID (4-CHLORO-3-NITRO-PYRAZOL-1-YL)-ACETIC ACID HYDRAZIDE

  • (4-nitro-1H-pyrazol-1-yl)acetic acid(SALTDATA: FREE)
  • ART-CHEM-BB B000219
  • CHEMBRDG-BB 5913009
  • (4-NITRO-PYRAZOL-1-YL)-ACETIC ACID
  • (4-NITRO-1H-PYRAZOL-1-YL)ACETIC ACID
  • AKOS B000219
  • AKOS PAO-0916
  • 2-(4-NITRO-1H-PYRAZOL-1-YL)ACETIC ACID
  • TIMTEC-BB SBB000166
  • 2-(4-nitro-1-pyrazolyl)acetic acid
  • 2-(4-nitropyrazol-1-yl)acetic acid
  • 2-(4-nitropyrazol-1-yl)ethanoic acid
  • 1H-Pyrazole-1-acetic acid, 4-nitro-
  • 6645-69-8