4-(2H-1,2,3,4-TETRAAZOL-5-YL)BENZOIC ACID
Uses- Product Name
- 4-(2H-1,2,3,4-TETRAAZOL-5-YL)BENZOIC ACID
- CAS No.
- 34114-12-0
- Chemical Name
- 4-(2H-1,2,3,4-TETRAAZOL-5-YL)BENZOIC ACID
- Synonyms
- DK7293;DK7430;NSC 282009;BUTTPARK 21\02-63;TIMTEC-BB SBB002457;5-(4-Carboxyphenyl)tetrazole;5-(p-Carboxyphenyl)tetrazole;4（1H-tetrazd-5-yl）benzoic acid;4-(2H-tetrazol-5-yl)benzoicaci;5-(4-Carboxyphenyl)-1H-tetrazole
- CBNumber
- CB7448780
- Molecular Formula
- C8H6N4O2
- Formula Weight
- 190.16
- MOL File
- 34114-12-0.mol
4-(2H-1,2,3,4-TETRAAZOL-5-YL)BENZOIC ACID Property
- Melting point:
- 248-250℃
- Boiling point:
- 467.5±47.0 °C(Predicted)
- Density
- 1.518
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 3?+-.0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C8H6N4O2/c13-8(14)6-3-1-5(2-4-6)7-9-11-12-10-7/h1-4H,(H,13,14)(H,9,10,11,12)
- InChIKey
- GEKBULKUEADYRB-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=C(C2=NNN=N2)C=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- T3917
- Product name
- 4-(1H-Tetrazol-5-yl)benzoic Acid
- Packaging
- 200MG
- Price
- $113
- Updated
- 2025/07/31
- Product number
- T3917
- Product name
- 4-(1H-Tetrazol-5-yl)benzoic Acid
- Packaging
- 1G
- Price
- $451
- Updated
- 2025/07/31
- Product number
- X6384
- Product name
- 4-(1H-Tetrazol-5-yl)benzoicAcid
- Packaging
- 1g
- Price
- $74
- Updated
- 2021/12/16
- Product number
- 033534
- Product name
- 4-(2H-Tetrazol-5-yl)-benzoic acid
- Packaging
- 1g
- Price
- $462
- Updated
- 2021/12/16
- Product number
- J57232
- Product name
- 4-(1H-Tetrazol-5-yl)benzoicAcid
- Packaging
- 25g
- Price
- $690
- Updated
- 2021/12/16
4-(2H-1,2,3,4-TETRAAZOL-5-YL)BENZOIC ACID Chemical Properties,Usage,Production
Uses
5-(4-Carboxyphenyl)-1H-tetrazole is an organic intermediate that can be prepared from 4-cyanobenzoic acid. Literature reports its potential use in the preparation of autocrine motor factor inhibitors.
Synthesis
619-65-8
34114-12-0
General procedure for the synthesis of 4-(1H-tetrazol-5-yl)benzoic acid from p-cyanobenzoic acid: p-cyanobenzoic acid (2 mmol), sodium azide (2.4 mmol, 1.2 eq.), and tetrabutylammonium bromide (2.4 mmol, 1.2 eq.) were added to a vial with a screw cap. The reaction mixture was stirred at 105 °C and the reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was cooled to room temperature and dissolved in deionized water (5 mL). Subsequently, the aqueous solution was acidified with 1 M hydrochloric acid to pH = 3. If precipitate formation was observed, the suspension was filtered and the filter cake was washed with deionized water to give pure 4-(1H-tetrazol-5-yl)benzoic acid. If no precipitate formed, the aqueous solution was extracted with ethyl acetate (3 x 4 mL). The organic phases were combined, washed with 1 M hydrochloric acid (3 x 4 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give pure 4-(1H-tetrazol-5-yl)benzoic acid.
References
[1] Journal of Chemical Research, 2013, vol. 37, # 11, p. 665 - 667
[2] Angewandte Chemie - International Edition, 2018, vol. 57, # 2, p. 511 - 515
[3] Angew. Chem., 2018, vol. 130, # 2, p. 520 - 524,5
[4] European Journal of Organic Chemistry, 2014, vol. 2014, # 2, p. 436 - 441
[5] European Journal of Organic Chemistry, 2014, vol. 2014, # 2, p. 436 - 441
4-(2H-1,2,3,4-TETRAAZOL-5-YL)BENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(2H-1,2,3,4-TETRAAZOL-5-YL)BENZOIC ACID manufacturers
- Product
- 4-(2H-tetrazol-5-yl)benzoic acid 34114-12-0
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-08-02
- Product
- 4-(1H-Tetrazol-5-yl)benzoic Acid 34114-12-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-25