ChemicalBook > CAS DataBase List > O-ISOBUTYLHYDROXYLAMINE HYDROCHLORIDE

O-ISOBUTYLHYDROXYLAMINE HYDROCHLORIDE

Product Name: O-ISOBUTYLHYDROXYLAMINE HYDROCHLORIDE
CAS No.: 6084-58-8
Chemical Name: O-ISOBUTYLHYDROXYLAMINE HYDROCHLORIDE
Synonyms: o-isobutylhydroxylamineHCl;Isobutoxyamine hydrochloride;ISOBUTYLOXYAMINE HYDROCHLORIDE;Isobutylhydroxylaminehydrochloride;O-(2-methylpropyl)hydroxylamine HCl;sec-Butyl hydroxyaMine hydrochloride;O-ISOBUTYLHYDROXYLAMINE HYDROCHLORIDE;O-IsobutylhydroxylamineHydrochloride>O-Isobutylhydroxylamine Hydrochloride
CBNumber: CB7450338
Molecular Formula: C4H12ClNO
Formula Weight: 125.6
MOL File: 6084-58-8.mol

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O-ISOBUTYLHYDROXYLAMINE HYDROCHLORIDE Property

Melting point:: 129°C
storage temp.: Inert atmosphere,2-8°C
form: powder to crystal
color: White to Almost white

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
HS Code: 2928009090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: I0387
Product name: O-Isobutylhydroxylamine Hydrochloride
Purity: >98.0%(N)
Packaging: 1g
Price: $124
Updated: 2025/07/31

TCI Chemical

Product number: I0387
Product name: O-Isobutylhydroxylamine Hydrochloride
Purity: >98.0%(N)
Packaging: 5g
Price: $369
Updated: 2025/07/31

TRC

Product number: I780140
Product name: O-Isobutylhydroxylamine Hydrochloride
Packaging: 500mg
Price: $165
Updated: 2021/12/16

AK Scientific

Product number: 7310AJ
Product name: O-Isobutylhydroxylamine Hydrochloride
Packaging: 5g
Price: $404
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0165496
Product name: ORTHO-ISOBUTYLHYDROXYLAMINE HYDROCHLORIDE
Purity: 98.00%
Packaging: 5G
Price: $1790.25
Updated: 2021/12/16

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O-ISOBUTYLHYDROXYLAMINE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

O-Isobutylhydroxylamine Hydrochloride is a reagent in the preparation of bis-hydroxy-benzophenone oxime ether derivatives as estrogen receptor (ER) agonist with complementary anti-cancer activities.

Synthesis

52026-51-4

6084-58-8

Under argon protection, 500 mg of hydroxyphthalimide (Aldrich) was dissolved in 5 mL of dimethylformamide, followed by the addition of 0.44 mL of 1-iodopentane (Aldrich) and 0.5 mL of 1,8-diazabicyclo[5.4.0]undec-7-ene (Aldrich) in a slow dropwise manner. The reaction mixture was stirred at 60 °C for 2 h. When the reaction was complete, it was cooled to room temperature and the reaction was quenched by the addition of 2N hydrochloric acid solution. The reaction solution was diluted with 20 mL of ethyl acetate, dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by silica gel column chromatography with the eluent of ethyl acetate/hexane (1:5), and 707 mg of the target compound was obtained after drying (yield: 99%). The compound was dissolved in 5 mL of dichloromethane and 0.15 mL of methylhydrazine (TCI) was slowly added at 0 °C. The reaction solution was stirred at room temperature for 2 hours and then cooled to 0°C again. The resulting solid was collected by filtration and 1 mL of 4 M dioxane hydrochloride solution (Aldrich) was added to the filtrate, filtered and dried to give 414 mg of solid product (yield: 98%). Under argon protection, 16 mg of the above solid was dissolved with 51 mg of SAC-0906 in 1 mL of pyridine (Aldrich) and stirred at 80 °C for 4 hours. After the reaction was completed, it was cooled to room temperature, acidified by adding 2N hydrochloric acid solution, extracted with 20 mL of ether, dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by silica gel column chromatography with the eluent of ethyl acetate/hexane (1:5) to afford O-isobutylhydroxylamine hydrochloride SAC-1016 (53 mg, yield: 89%).1H-NMR (300 MHz, CDCl3) δ 5.91-5.76 (m, 2H), 5.34-5.32 (m, 1H), 5.27 -5.24 (m, 1H), 5.14 (m, 1H), 4.24-4.10 (m, 3H), 4.00-3.96 (m, 2H), 3.61-3.49 (m, 1H), 2.41-0.60 (m, 44H).

References

[1] Patent: US2014/378399, 2014, A1. Location in patent: Paragraph 0102
[2] Journal of Pharmacology and Experimental Therapeutics, 1999, vol. 288, # 2, p. 490 - 501
[3] European Journal of Medicinal Chemistry, 2014, vol. 75, p. 184 - 194
[4] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 7, p. 1844 - 1848

O-ISOBUTYLHYDROXYLAMINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from O-ISOBUTYLHYDROXYLAMINE HYDROCHLORIDE manufacturers

Career Henan Chemical Co

Product: O-ISOBUTYLHYDROXYLAMINE HYDROCHLORIDE 6084-58-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-26

6084-58-8, O-ISOBUTYLHYDROXYLAMINE HYDROCHLORIDERelated Search:

Clomazone O-ISOBUTYLHYDROXYLAMINE HYDROCHLORIDE 1-(2,4-DICHLOROBENZYL)-3-[(ISOBUTYRYLOXY)IMINO]-1,3-DIHYDRO-2H-INDOL-2-ONE 5-[(2-CHLOROBENZYL)SULFANYL]-4-([(ISOBUTYRYLOXY)IMINO]METHYL)-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE DIMETHYL 5-(2-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]AMINO)ETHYL)-4,6-DIOXOTETRAHYDRO-2H-PYRROLO[3,4-D]ISOXAZOLE-3,3(3AH)-DICARBOXYLATE 3-([(3-CHLORO-2,2-DIMETHYLPROPANOYL)OXY]IMINO)-1-(4-METHYLBENZYL)-1,3-DIHYDRO-2H-INDOL-2-ONE 5-[(2-CHLOROBENZYL)SULFANYL]-4-(([(CYCLOPROPYLCARBONYL)OXY]IMINO)METHYL)-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE 5-[(4-CHLOROPHENYL)SULFANYL]-4-([(ISOBUTYRYLOXY)IMINO]METHYL)-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE 5-(2-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]AMINO)ETHYL)-3,3-SPIRO-2-(5,5-DIMETHYL CYCLOHEXANE-1,3-DIONYL)DIHYDRO-2H-PYRROLO[3,4-D]ISOXAZOLE-4,6-(3H,5H)-DIONE 1-(2,4-DICHLOROBENZYL)-3-([(2,2-DIMETHYLPROPANOYL)OXY]IMINO)-1,3-DIHYDRO-2H-INDOL-2-ONE N'-[(3-CHLORO-2,2-DIMETHYLPROPANOYL)OXY]-N-(4,6-DIMETHOXYPYRIMIDIN-2-YL)IMINOFORMAMIDE 5-(2-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]AMINO)ETHYL)-3-(4-METHOXYPHENYL)-2-METHYLDIHYDRO-2H-PYRROLO[3,4-D]ISOXAZOLE-4,6(3H,5H)-DIONE 5-(2-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]AMINO)ETHYL)-2,3-DIPHENYLDIHYDRO-2H-PYRROLO[3,4-D]ISOXAZOLE-4,6(3H,5H)-DIONE 1-CHLORO-4-(([(CYCLOHEXYLCARBONYL)OXY]IMINO)METHYL)BENZENE 5-(2-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]AMINO)ETHYL)-2-METHYL-3-PHENYLDIHYDRO-2H-PYRROLO[3,4-D]ISOXAZOLE-4,6(3H,5H)-DIONE 1-(3,4-DICHLOROBENZYL)-3-[(ISOBUTYRYLOXY)IMINO]-1,3-DIHYDRO-2H-INDOL-2-ONE O1-(2,2-DIMETHYLPROPANOYL)-2-CHLOROETHANEHYDROXIMAMIDE 1-(4-CHLOROBENZYL)-3-([(3-CHLORO-2,2-DIMETHYLPROPANOYL)OXY]IMINO)-1,3-DIHYDRO-2H-INDOL-2-ONE

sec-Butyl hydroxyaMine hydrochloride

Isobutoxyamine hydrochloride

<i>O</i>-Isobutylhydroxylamine Hydrochloride

O-ISOBUTYLHYDROXYLAMINE HYDROCHLORIDE

ISOBUTYLOXYAMINE HYDROCHLORIDE

Isobutylhydroxylaminehydrochloride

o-isobutylhydroxylamineHCl

O-(2-methylpropyl)hydroxylamine HCl

O-IsobutylhydroxylamineHydrochloride&gt

6084-58-8

C4H12ClNO

Hydroxylamines (O-Substituted)

Hydroxylamines

Hydroxylamines (O-Substituted)