METHYL 2,6-DICHLORO-5-FLUORONICOTINATE
- Product Name
- METHYL 2,6-DICHLORO-5-FLUORONICOTINATE
- CAS No.
- 189281-66-1
- Chemical Name
- METHYL 2,6-DICHLORO-5-FLUORONICOTINATE
- Synonyms
- METHYL 2,6-DICHLORO-5-FLUORONICOTINATE;Methyl2,6-dichloro-5-fluoronicotinate97%;Methyl 2,6-dichloro-5-fluoropyridine-3-carboxylate;2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid methyl ester;3-Pyridinecarboxylicacid, 2,6-dichloro-5-fluoro-, methyl ester;Methyl 2,6-dichloro-5-fluoropyridine-3-carboxylate, 2,6-Dichloro-3-fluoro-5-(methoxycarbonyl)pyridine
- CBNumber
- CB7452488
- Molecular Formula
- C7H4Cl2FNO2
- Formula Weight
- 224.02
- MOL File
- 189281-66-1.mol
METHYL 2,6-DICHLORO-5-FLUORONICOTINATE Property
- Boiling point:
- 84 °C
- Density
- 1.506±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -5.43±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C7H4Cl2FNO2/c1-13-7(12)3-2-4(10)6(9)11-5(3)8/h2H,1H3
- InChIKey
- WADLLLSMEPLCNO-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(Cl)=C(F)C=C1C(OC)=O
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- Hazard Note
- Irritant
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M326368
- Product name
- Methyl2,6-Dichloro-5-fluoronicotinate
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- PC6724
- Product name
- Methyl2,6-dichloro-5-fluoronicotinate
- Packaging
- 5g
- Price
- $119
- Updated
- 2021/12/16
- Product number
- 083415
- Product name
- Methyl 2,6-dichloro-5-fluoronicotinate
- Purity
- 97%
- Packaging
- 1g
- Price
- $139
- Updated
- 2021/12/16
- Product number
- PC6724
- Product name
- Methyl2,6-dichloro-5-fluoronicotinate
- Packaging
- 1g
- Price
- $36
- Updated
- 2021/12/16
- Product number
- 4H23-7-01
- Product name
- Methyl 2,6-dichloro-5-fluoronicotinate
- Packaging
- 1g
- Price
- $64
- Updated
- 2021/12/16
METHYL 2,6-DICHLORO-5-FLUORONICOTINATE Chemical Properties,Usage,Production
Synthesis
67-56-1
82671-06-5
189281-66-1
At 0°C, 2,6-dichloro-5-fluoropyridine-3-carboxylic acid (5 g, 23.8 mmol) was dissolved in methanol (50 ml) and thionyl chloride (5.66 g, 47.62 mmol) and 2 drops of DMF were added slowly [vigorous bulging was observed]. The reaction mixture was stirred at room temperature for 3 hours. Subsequently, methanol was added to the reaction system and stirring was continued for 2 hours at room temperature. Upon completion of the reaction, the mixture was concentrated under reduced pressure and the residue was poured into ice-cold water (20 mL) and extracted with dichloromethane (2 x 50 mL). The organic layers were combined, washed sequentially with water and brine, and the solvent was evaporated under reduced pressure to afford methyl 2,6-dichloro-5-fluoropyridine-3-carboxylate (5 g, 93.8% yield).
References
[1] Patent: US2015/25087, 2015, A1. Location in patent: Paragraph 0168; 0198; 0199
[2] Patent: WO2016/51193, 2016, A1. Location in patent: Paragraph 00667; 00668; 00669
[3] Patent: TW2017/14884, 2017, A. Location in patent: Paragraph 0076
[4] Patent: EP2589592, 2018, B1. Location in patent: Paragraph 0563; 0564
[5] Patent: WO2010/126851, 2010, A1. Location in patent: Page/Page column 108-109
METHYL 2,6-DICHLORO-5-FLUORONICOTINATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYL 2,6-DICHLORO-5-FLUORONICOTINATE manufacturers
- Product
- METHYL 2,6-DICHLORO-5-FLUORONICOTINATE 189281-66-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- follow your request
- Release date
- 2023-06-01
- Product
- METHYL 2,6-DICHLORO-5-FLUORONICOTINATE 189281-66-1
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2020-01-13