Pazinaclone

Product Name: Pazinaclone
CAS No.: 103255-66-9
Chemical Name: Pazinaclone
Synonyms: A77000;A-77000;DN-2327;A 77000;Paz·Naclone;Pazinaclone;2-(7-chloro-1,8-naphthyridin-2-yl)-3-[2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-2-oxoethyl]-3h-isoindol-1-one;2-(7-Chloro-1,8-naphthyridine-2-yl)-3-[2-oxo-2-(1,4-dioxa-8-azaspiro[4.5]decane-8-yl)ethyl]isoindoline-1-one;8-[[2-(7-Chloro-1,8-naphthyridin-2-y1)-2，3-dihydro-3-oxo-1H-isoindol-1-y1]acetyl]-1，4-dioxa-8-azaspiro[4.5]decane;8-[[[2-(7-Chloro-1,8-naphthyridin-2-yl)-2,3-dihydro-3-oxo-1H-isoindol]-1-yl]acetyl]-1,4-dioxa-8-azaspiro[4.5]decane
CBNumber: CB7453773
Molecular Formula: C25H23ClN4O4
Formula Weight: 478.93
MOL File: 103255-66-9.mol

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Pazinaclone Property

Melting point:: 238-239°
Boiling point:: 712.5±60.0 °C(Predicted)
Density: 1.48±0.1 g/cm3(Predicted)
pka: 1.62±0.30(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0003761
Product name: PAZINACLONE
Purity: 95.00%
Packaging: 100MG
Price: $885.31
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0003761
Product name: PAZINACLONE
Purity: 95.00%
Packaging: 1G
Price: $2804.55
Updated: 2021/12/16

AHH

Product number: MT-57662
Product name: Pazinaclone
Purity: 98%
Packaging: 0.5g
Price: $910
Updated: 2021/12/16

Chemenu

Product number: CM139296
Product name: 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(2-oxo-2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)ethyl)isoindolin-1-one
Purity: 95%
Packaging: 1g
Price: $1342
Updated: 2021/12/16

Crysdot

Product number: CD31004783
Product name: Pazinaclone
Purity: 95+%
Packaging: 1g
Price: $1424
Updated: 2021/12/16

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Pazinaclone Chemical Properties,Usage,Production

Description

Pazinaclone is a nonbenzodiazepine partial agonist. Animal work has shown that it has anxiolytic and anticonvulsant activity. Pazinaclone does not, however, produce the sedative, muscle relaxant, or motor coordination effects seen with diazepam (Waka and Fukada 1991). Phase II clinical trials are currently under way in the United States, Europe, and Japan, which have so far demonstrated that it is well tolerated and seems to cause significantly less sedation than do benzodiazepines (Uchiumi et al. 1992).

Uses

Anti-anxiety agent.

Pharmacokinetics

Pazinaclone is a sedative and anxiolytic drug in the cyclopyrrolone family of drugs. Other cyclopyrrolone drugs include zopiclone and eszopiclone. Pazinaclone has a very similar pharmacological profile to the benzodiazepine family of drugs including sedative and anxiolytic properties, but with less amnestic effects, and at low doses it is a relatively selective anxiolytic, with sedative effects only appearing at higher doses. Pazinaclone produces its sedative and anxiolytic effects by acting as a partial agonist at GABAA benzodiazepine receptors, although pazinaclone is more subtype-selective than most benzodiazepines.

Pazinaclone Preparation Products And Raw materials

Raw materials

Phosphine

Preparation Products

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Pazinaclone Suppliers

China 15 Europe 2 Germany 1 South Korea 1 United Kingdom 3 United States 10 Global 32

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: 571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52849
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49374
Advantage: 58

Suzhou Zhixin Biotechnology Co., Ltd.

Tel: 0512-65118909 15162312715
Email: sales@szzxbio.com
Country: China
ProdList: 2988
Advantage: 58

Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 11974
Advantage: 58

Baoji Didu Pharmaceutical and Chemical Co., Ltd

Tel: 02961856358 15829046862
Email: 1035@dideu.com
Country: China
ProdList: 10011
Advantage: 58

Shandong Mingde Biotechnology Co., Ltd

Tel: 15553348166
Email: m15553348166@163.com
Country: China
ProdList: 15200
Advantage: 58

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View Lastest Price from Pazinaclone manufacturers

Xiamen Wonderful Bio Technology Co., Ltd.

Product: Pazinaclone 103255-66-9
Price: US $88.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100000T
Release date: 2023-07-21

103255-66-9, PazinacloneRelated Search:

Isoindoline Nitrogen 4-HYDROXY-PIPERIDINE-1-CARBALDEHYDE 3-AMINO-N,N-DIETHYL-PROPIONAMIDE HCL L-Alaninol 4-Piperidone hydrochloride hydrate 2-(N-METHYL-2-AMINOETHYL)-1,3-DIOXOLANE 1-(3-AMINO-PROPYL)-PIPERIDIN-4-OL 3-AMINO-1-PIPERIDIN-4-YL-PROPAN-1-ONE HYDROCHLORIDE 1,4-Dioxa-8-azaspiro[4.5]decane Pazinaclone 1-ACETYLPIPERIDIN-4-OL 1 4-DIOXA-8-AZASPIRO(4.5)DECANE 1-Piperidinepropanamine, -phenyl- 2-CHLORO-1,8-NAPHTHYRIDINE

2-(7-chloro-1,8-naphthyridin-2-yl)-3-[2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-2-oxoethyl]-3h-isoindol-1-one

8-[[2-(7-Chloro-1,8-naphthyridin-2-y1)-2，3-dihydro-3-oxo-1H-isoindol-1-y1]acetyl]-1，4-dioxa-8-azaspiro[4.5]decane

DN-2327

2-(7-Chloro-1,8-naphthyridine-2-yl)-3-[2-oxo-2-(1,4-dioxa-8-azaspiro[4.5]decane-8-yl)ethyl]isoindoline-1-one

8-[[[2-(7-Chloro-1,8-naphthyridin-2-yl)-2,3-dihydro-3-oxo-1H-isoindol]-1-yl]acetyl]-1,4-dioxa-8-azaspiro[4.5]decane

Pazinaclone

Paz·Naclone

1H-Isoindol-1-one,2-(7-chloro-1,8-naphthyridin-2-yl)-3-[2-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-2-oxoethyl]-2,3-dihydro-

A 77000

A77000

A-77000

103255-66-9

C25H23ClN4O4

C25H23CIN4O4