4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE

Product Name: 4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE
CAS No.: 221529-58-4
Chemical Name: 4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE
Synonyms: CAY10441;RO1138452;CAY10441 RO1138452;RO1138452 CAY10441;CAY10441 Exclusive;RO1138452, 10 mM in DMSO;RO 1138452;RO-1138452;RO1138452;CAY 10441;CAY-10441;CAY10441;N-(4-(4-Isopropoxybenzyl)phenyl)-4,5-dihydro-1H-imidazol-2-amine;4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE;1H-Imidazol-2-amine, 4,5-dihydro-N-[4-[[4-(1-methylethoxy)phenyl]methyl]phenyl]-
CBNumber: CB7455737
Molecular Formula: C19H23N3O
Formula Weight: 309.41
MOL File: 221529-58-4.mol

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4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE Property

Boiling point:: 449.7±47.0 °C(Predicted)
Density: 1.13±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMF: 30 mg/ml; DMF:PBS (pH 7.2)(1:10): 0.05 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml
form: A crystalline solid
pka: 9.94±0.33(Predicted)
color: Light yellow to brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10005186
Product name: CAY10441
Purity: ≥98%
Packaging: 5mg
Price: $150
Updated: 2024/03/01

Cayman Chemical

Product number: 10005186
Product name: CAY10441
Purity: ≥98%
Packaging: 10mg
Price: $230
Updated: 2024/03/01

Cayman Chemical

Product number: 10005186
Product name: CAY10441
Purity: ≥98%
Packaging: 25mg
Price: $558
Updated: 2024/03/01

Cayman Chemical

Product number: 10005186
Product name: CAY10441
Purity: ≥98%
Packaging: 50mg
Price: $916
Updated: 2024/03/01

ChemScene

Product number: CS-0031508
Product name: RO1138452
Purity: 98.21%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

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4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE Chemical Properties,Usage,Production

Uses

RO1138452 is a potent and selective IP (prostacyclin) receptor antagonist. RO1138452 displays high affinity for IP receptors. In human platelets, pKi is 9.3±0.1; in a recombinant IP receptor system, pKi is 8.7±0.06.

in vivo

RO1138452 is a potent and selective antagonist for both human and rat IP receptors and that is possesses analgesic and anti-inflammatory potential. RO1138452 (1-10 mg/kg, i.v.) significantly reduces acetic acid-induced abdominal constrictions. RO1138452 (3-100 mg/kg, p.o.) significantly reduces carrageenan-induced mechanical hyperalgesia and edema formation. One hour after administration of RO1138452 (5 mg/kg, i.v.) to rats, the total plasma concentration is 0.189 μg/mL, whereas the free plasma concentrations is calculated to be 0.009 μg/mL (28 nM)^[1].

IC 50

Rat I₂ Receptor: 7 nM (IC₅₀); Rat I₂ Receptor: 8.33 (pKi); Rabbit PAF Receptor: 52.9 nM (IC₅₀); Human α_2A adrenoceptor: 724 nM (IC₅₀); Rat α_1B adrenoceptor: 3280 nM (IC₅₀); Human Muscarinic M₄ Receptor: 1450 nM (IC₅₀); Human muscarinic M₂ Receptor: 2220 nM (IC₅₀); Human muscarinic M₁ Receptor: 2570 nM (IC₅₀); Human muscarinic M₅ Receptor: 3110 nM (IC₅₀); Rat 5-HT_1B Receptor: 1130 nM (IC₅₀); pig 5-HT_2C Receptor: 1190 nM (IC₅₀); Rat 5-HT_2A Receptor: 3040 nM (IC₅₀); Human 5-HT_1A Receptor: 8580 nM (IC₅₀); Guinea-pig 5-HT₄ Receptor: 8910 nM (IC₅₀); Rat α_1B adrenoceptor: 5.87 (pKi); Human α_2A adrenoceptor: 6.49 (pKi); Human muscarinic M₁ Receptor: 5.66 (pKi); Human muscarinic M₅ Receptor: 5.81 (pKi); Human muscarinic M₂ Receptor: 5.88 (pKi); Human muscarinic M₄ Receptor: 6.14 (pKi); Rabbit PAF Receptor: 7.9 (pKi); Guinea-pig 5-HT₄ Receptor: 5.35 (pKi); Human 5-HT_1A Receptor: 5.37 (pKi); Rat 5-HT_2A Receptor: 5.71 (pKi); Rat 5-HT_1B Receptor: 6.11 (pKi); Pig 5-HT_2C Receptor: 6.11 (pKi)

References

[1] Bley KR, et al. RO1138452 and RO3244794: characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists. Br J Pharmacol. 2006 Feb;147(3):335-45. DOI:10.1038/sj.bjp.0706554
[2] Ayer LM, et al. 4,5-Dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxy-benzyl)-phenyl]-amine (RO1138452) is a selective, pseudo-irreversible orthosteric antagonist at the prostacyclin (IP)-receptor expressed by human airway epithelial cells: IP-receptor-mediated inhibition of CXCL9 and CXCL10 release. J Pharmacol Exp Ther. 2008 Feb;324(2):815-26. DOI:10.1124/jpet.107.129312

4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE Suppliers

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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

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View Lastest Price from 4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE manufacturers

Career Henan Chemical Co

Product: 4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE 221529-58-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-25

221529-58-4, 4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINERelated Search:

4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]CARBONYL]PHENYL]-1H-IMIDAZOL-2-AMINE 4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE

4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]METHYL]PHENYL]-1H-IMIDAZOL-2-AMINE

RO1138452

CAY10441 Exclusive

N-(4-(4-Isopropoxybenzyl)phenyl)-4,5-dihydro-1H-imidazol-2-amine

CAY10441 RO1138452

CAY10441

RO1138452 CAY10441

RO 1138452;RO-1138452;RO1138452;CAY 10441;CAY-10441;CAY10441

1H-Imidazol-2-amine, 4,5-dihydro-N-[4-[[4-(1-methylethoxy)phenyl]methyl]phenyl]-

RO-1138452,Inhibitor,RO1138452,CAY 10441,inhibit,CAY-10441,Prostaglandin Receptor,RO 1138452

RO1138452, 10 mM in DMSO

221529-58-4

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