ChemicalBook > CAS DataBase List > 1-(4-Nitrophenyl)piperidine

1-(4-Nitrophenyl)piperidine

Product Name: 1-(4-Nitrophenyl)piperidine
CAS No.: 6574-15-8
Chemical Name: 1-(4-Nitrophenyl)piperidine
Synonyms: AURORA 2061;BUTTPARK 96\57-87;4-CHLORO-2-AMINOPYRIMIDINE;N-(4-NITROPHENYL)PIPERIDINE;1-(4-NITROPHENYL)PIPERIDINE;1-Piperidino-4-nitrobenzene;Piperidine, 1-(4-nitrophenyl)-;6-amino-1,3-dimethyl-5-[2-[[3-(4-methylphenyl)-4-oxo-2-quinazolinyl]thio]-1-oxoethyl]pyrimidine-2,4-dione
CBNumber: CB7455858
Molecular Formula: C11H14N2O2
Formula Weight: 206.24
MOL File: 6574-15-8.mol

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1-(4-Nitrophenyl)piperidine Property

Melting point:: 104-106°C
Boiling point:: 363.5±25.0 °C(Predicted)
Density: 1.188±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 1.92±0.20(Predicted)
CAS DataBase Reference: 6574-15-8(CAS DataBase Reference)

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Safety

Risk Statements: 20/21/22
Safety Statements: 22-36
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S539198
Product name: 1-(4-NITROPHENYL)PIPERIDINE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $113
Updated: 2025/07/31

Sigma-Aldrich

Product number: S539198
Product name: 1-(4-NITROPHENYL)PIPERIDINE
Purity: AldrichCPR
Packaging: 250MG
Price: $110
Updated: 2024/03/01

TRC

Product number: N545310
Product name: 1-(4-Nitrophenyl)piperidine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: J94523
Product name: 1-(4-Nitrophenyl)piperidine
Packaging: 1g
Price: $10
Updated: 2021/12/16

Matrix Scientific

Product number: 071904
Product name: 1-(4-Nitrophenyl)piperidine
Purity: 95+%
Packaging: 5g
Price: $23
Updated: 2021/12/16

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1-(4-Nitrophenyl)piperidine Chemical Properties,Usage,Production

Definition

ChEBI: 1-(4-nitrophenyl)piperidine is a member of piperidines.

Synthesis

110-89-4

100-00-5

6574-15-8

General procedure for the synthesis of 1-(4-nitrophenyl)piperidine from hexahydropyridine and 4-chloronitrobenzene: 4-chloronitrobenzene (100 mg, 0.63 mmol), piperidine (63.86 mg, 0.75 mmol), and SS-Pd (284.5 mg containing 0.01 mmol Pd) were placed in a round-bottomed flask and DMF was added as a solvent. The reaction mixture was heated at 80 °C with magnetic stirring for 6 h. The reaction process was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was cooled to room temperature, diluted with water and extracted three times with ethyl acetate. The organic layers were combined and concentrated to obtain the crude product. The crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 90:10) to afford 1-(4-nitrophenyl)piperidine (22) as a pale yellow solid (112 mg, 86% yield) with a melting point of 104-105 °C. 1H NMR (300 MHz, CDCl3) δ 8.05-8.09 (m, 2H), 6.76-6.79 (m 2H), 3.43 (m, 4H), 1.68 (m, 6H); 13C NMR (75 MHz, CDCl3) δ 155.28, 137.70, 126.27 (2C), 112.20 (2C), 48.72 (2C), 25.66 (2C), 24.61; high-resolution mass spectrometry (HRMS-ESI) calculated values [M+ H]+ C11H15N2O2 207.2490, measured value 207.2472.

References

[1] Bulletin of the Chemical Society of Japan, 1991, vol. 64, # 1, p. 42 - 49
[2] Chemistry Letters, 1987, p. 1187 - 1190
[3] Monatshefte fur Chemie, 2003, vol. 134, # 1, p. 37 - 43
[4] European Journal of Organic Chemistry, 2010, # 19, p. 3621 - 3630
[5] Synthetic Communications, 2000, vol. 30, # 24, p. 4479 - 4488

1-(4-Nitrophenyl)piperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-(4-Nitrophenyl)piperidine manufacturers

Career Henan Chemical Co

Product: 1-(4-Nitrophenyl)piperidine 6574-15-8
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 200kg
Release date: 2018-12-17

6574-15-8, 1-(4-Nitrophenyl)piperidineRelated Search:

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1-Piperidino-4-nitrobenzene

BUTTPARK 96\57-87

AURORA 2061

1-(4-NITROPHENYL)PIPERIDINE

N-(4-NITROPHENYL)PIPERIDINE

4-CHLORO-2-AMINOPYRIMIDINE

6-amino-1,3-dimethyl-5-[2-[[3-(4-methylphenyl)-4-oxo-2-quinazolinyl]thio]-1-oxoethyl]pyrimidine-2,4-dione

Piperidine, 1-(4-nitrophenyl)-

6574-15-8

Phenyls & Phenyl-Het

Piperidine

CHIRAL CHEMICALS

Phenyls & Phenyl-Het