ChemicalBook > CAS DataBase List > 1-(METHYLSULFONYL)PIPERIDIN-4-AMINE

1-(METHYLSULFONYL)PIPERIDIN-4-AMINE

Product Name
1-(METHYLSULFONYL)PIPERIDIN-4-AMINE
CAS No.
402927-97-3
Chemical Name
1-(METHYLSULFONYL)PIPERIDIN-4-AMINE
Synonyms
AKOS B025717;ART-CHEM-BB B025717;4-AMino-1-(Methanesulfony...;1-(METHYLSULFONYL)PIPERIDIN-4-AMINE;1-(Methylsulfonyl)-4-piperidinamine;1-(Methylsulfonyl)-4-aminopiperidin;1-(Methylsulfonyl)-4-aMinopiperidine;4-AMino-1-(Methylsulfonyl)piperidine;4-AMINO-1-METHANESULFONYLPIPERIDINE;1-Methanesulfonyl-piperidin-4-ylamine
CBNumber
CB7456037
Molecular Formula
C6H14N2O2S
Formula Weight
178.25
MOL File
402927-97-3.mol
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1-(METHYLSULFONYL)PIPERIDIN-4-AMINE Property

Boiling point:
296.0±50.0 °C(Predicted)
Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
solid
pka
9.45±0.20(Predicted)
Appearance
White to light yellow Solid
InChI
InChI=1S/C6H14N2O2S/c1-11(9,10)8-4-2-6(7)3-5-8/h6H,2-5,7H2,1H3
InChIKey
FLQSRSQNICPZIH-UHFFFAOYSA-N
SMILES
N1(S(C)(=O)=O)CCC(N)CC1
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
A612973
Product name
4-Amino-1-methanesulfonylpiperidine
Packaging
50mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
W6078
Product name
1-(methylsulfonyl)piperidin-4-amine
Packaging
250mg
Price
$74
Updated
2021/12/16
Matrix Scientific
Product number
072846
Product name
4-Amino-1-(methylsulfonyl)piperidine
Purity
95+%
Packaging
1g
Price
$462
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0018103
Product name
1-METHANESULFONYL-PIPERIDIN-4-YLAMINE
Purity
95.00%
Packaging
0.5G
Price
$726
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0018103
Product name
1-METHANESULFONYL-PIPERIDIN-4-YLAMINE
Purity
95.00%
Packaging
1G
Price
$808.5
Updated
2021/12/16
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1-(METHYLSULFONYL)PIPERIDIN-4-AMINE Chemical Properties,Usage,Production

Synthesis

287953-38-2

402927-97-3

General procedure for the synthesis of 1-methylsulfonyl-4-aminopiperidine from 1-MS-4-Boc-aminopiperidine: 6.30 g (22.63 mmol) of tert-butyl (1-methylsulfonyl-piperidin-4-yl)-carbamate was dissolved in 74 mL of dichloromethane (DCM) followed by the addition of 17.4 mL (226 mmol) of trifluoroacetic acid (TFA). The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was diluted with diethyl ether at 40 °C, the precipitate was collected by filtration, washed with water and dried. The dried product was dissolved in methanol (MeOH), polymer-loaded bicarbonate (PL-HCO3 MP resin, Agilent Technologies) was added, and the suspension was stirred for several minutes. The resin was subsequently removed by filtration and the solvent was removed by distillation under reduced pressure to give 4.00 g of 1-methylsulfonyl-piperidin-4-ylamine. Yield: 99%; ESI-MS: 179 [M + H]+; HPLC (retention time): 0.26 min (Method E).

References

[1] Patent: US8865744, 2014, B1. Location in patent: Page/Page column 26
[2] Patent: WO2014/184327, 2014, A1. Location in patent: Page/Page column 27
[3] Patent: US2015/225367, 2015, A1. Location in patent: Paragraph 0406
[4] Journal of Medicinal Chemistry, 2006, vol. 49, # 22, p. 6549 - 6560
[5] Bioorganic Chemistry, 2015, vol. 61, p. 21 - 27

1-(METHYLSULFONYL)PIPERIDIN-4-AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(METHYLSULFONYL)PIPERIDIN-4-AMINE Suppliers

China 115 Germany 2 India 1 Russia 1 United States 16 Global 135
Accela ChemBio Inc.
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View Lastest Price from 1-(METHYLSULFONYL)PIPERIDIN-4-AMINE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
1-(METHYLSULFONYL)PIPERIDIN-4-AMINE 402927-97-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Career Henan Chemical Co
Product
1-(METHYLSULFONYL)PIPERIDIN-4-AMINE 402927-97-3
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2018-08-08

402927-97-3, 1-(METHYLSULFONYL)PIPERIDIN-4-AMINERelated Search:

1-(METHYLSULFONYL)PIPERIDIN-4-AMINE HYDROCHLORIDE N-ISOPROPYL-N'-(1-[(4-METHOXYPHENYL)SULFONYL]-4-PIPERIDINYL)UREA N-(1-[(4-CHLOROPHENYL)SULFONYL]-4-PIPERIDINYL)-4-MORPHOLINECARBOXAMIDE N-CYCLOPROPYL-N-[(4-METHOXYPHENYL)SULPHONYLPIPERIDIN-4-YL]BENZENESULPHONAMIDE 2,4,5-TRICHLOROPHENYL N-(1-[(4-METHOXYPHENYL)SULFONYL]-4-PIPERIDINYL)CARBAMATE METHYL N-(1-[(4-CHLOROPHENYL)SULFONYL]-4-PIPERIDINYL)CARBAMATE 4-METHOXYBENZYL N-(1-[(4-CHLOROPHENYL)SULFONYL]-4-PIPERIDINYL)CARBAMATE 4-CHLOROBENZYL N-(1-[(4-CHLOROPHENYL)SULFONYL]-4-PIPERIDINYL)CARBAMATE N-[((4-CHLOROPHENYL)SULPHONYL)PIPERIDIN-4-YL]-3-(TRIFLUOROMETHYL)BENZENESULPHONAMIDE 2,4-DICHLOROBENZYL N-(1-[(4-CHLOROPHENYL)SULFONYL]-4-PIPERIDINYL)CARBAMATE ISOPROPYL N-(1-[(4-METHYLPHENYL)SULFONYL]-4-PIPERIDINYL)CARBAMATE N-(1-[(4-CHLOROPHENYL)SULFONYL]-4-PIPERIDINYL)-1-PYRROLIDINECARBOXAMIDE N-(1-[(4-CHLOROPHENYL)SULFONYL]-4-PIPERIDINYL)-N'-ISOPROPYLUREA METHYL N-(1-[(4-METHYLPHENYL)SULFONYL]-4-PIPERIDINYL)CARBAMATE N-CYCLOPROPYL-N-[(PHENYLSULPHONYL)PIPERIDIN-4-YL]-3-(TRIFLUOROMETHYL)BENZENESULPHONAMIDE 4-CHLORO-N-CYCLOPROPYL-N-[[1-(3-TRIFLUOROMETHYL)PHENYLSULPHONYL]PIPERIDIN-4-YL]BENZENESULPHONAMIDE N-(1-[(4-METHYLPHENYL)SULFONYL]-4-PIPERIDINYL)-1-PYRROLIDINECARBOXAMIDE ISOPROPYL N-(1-[(4-CHLOROPHENYL)SULFONYL]-4-PIPERIDINYL)CARBAMATE

  • AKOS B025717
  • 4-Amino-N-1-(methylsulfonyl)piperidine
  • 4-AMINO-1-METHANESULFONYLPIPERIDINE
  • 1-Methanesulfonyl-piperidin-4-ylamine
  • ART-CHEM-BB B025717
  • 1-(METHYLSULFONYL)PIPERIDIN-4-AMINE
  • 1-(methylsulfonyl)-4-piperidinamine(SALTDATA: HCl)
  • 1-(methylsulfonyl)-4-piperidinamine 1HCl
  • 4-AMino-1-(Methanesulfony...
  • 4-AMino-1-(Methylsulfonyl)piperidine
  • 1-(Methylsulfonyl)-4-aMinopiperidine
  • 1-(Methylsulfonyl)-4-piperidinamine
  • 4-Piperidinamine, 1-(methylsulfonyl)-
  • 4-Amino-1-methanesulfonylpiperidine, TFA salt
  • 1-(Methylsulfonyl)-4-aminopiperidin
  • 402927-97-3