2,5-DIFLUOROBENZENESULFONYL CHLORIDE
- Product Name
- 2,5-DIFLUOROBENZENESULFONYL CHLORIDE
- CAS No.
- 26120-86-5
- Chemical Name
- 2,5-DIFLUOROBENZENESULFONYL CHLORIDE
- Synonyms
- AKOS B019395;BUTTPARK 21\07-13;ART-CHEM-BB B019395;2,5-DIAMIONPYRIMIDINE;2,5-Difluorobenzenesulphonylchlori;2,5-DIFLUOROBENZENESULFONYL CHLORIDE;2,3-Difluorobenzenesulfonyl chloride;2,5-DIFLUOROBENZENESULPHONYL CHLORIDE;2,5-Difluorobenzenesulphonylchloride98%;2,5-difluorobenzene-1-sulfonyl chloride
- CBNumber
- CB7456219
- Molecular Formula
- C6H3ClF2O2S
- Formula Weight
- 212.6
- MOL File
- 26120-86-5.mol
2,5-DIFLUOROBENZENESULFONYL CHLORIDE Property
- Boiling point:
- 221 °C (lit.)
- Density
- 1.58 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.516(lit.)
- Flash point:
- >230 °F
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- liquid
- color
- Clear, yellow/green
- Sensitive
- Moisture Sensitive
- BRN
- 2723886
- CAS DataBase Reference
- 26120-86-5(CAS DataBase Reference)
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 3265 8/PG 2
- WGK Germany
- 3
- Hazard Note
- Corrosive
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29049090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 555428
- Product name
- 2,5-Difluorobenzenesulfonyl chloride
- Purity
- 97%
- Packaging
- 5g
- Price
- $50.8
- Updated
- 2023/06/20
- Product number
- 555428
- Product name
- 2,5-Difluorobenzenesulfonyl chloride
- Purity
- 97%
- Packaging
- 1g
- Price
- $24
- Updated
- 2023/01/07
- Product number
- D451393
- Product name
- 2,5-Difluorobenzenesulfonyl chloride
- Packaging
- 2.5g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- D451393
- Product name
- 2,5-Difluorobenzenesulfonyl chloride
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- D451393
- Product name
- 2,5-Difluorobenzenesulfonyl chloride
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
2,5-DIFLUOROBENZENESULFONYL CHLORIDE Chemical Properties,Usage,Production
Chemical Properties
Clear colorless to yellow liquid
General Description
2,5-Difluorobenzenesulfonyl chloride participates in the synthesis of aryl sulfonamide-based mineralocorticoid receptor (MR) antagonists.
Synthesis
367-30-6
26120-86-5
The general procedure for the synthesis of 2,5-difluorobenzenesulfonyl chloride from 2,5-difluoroaniline was as follows: 12.9 g (99.9 mmol) of 2,5-difluoroaniline was rapidly added to a mixture prepared from 33 mL of concentrated hydrochloric acid and 10 mL of acetic acid in ethanol cooled to just below -10°C. The solution of 2,5-difluorobenzenesulfonyl chloride in ethanol was then added dropwise. Subsequently, a solution of 7.4 g (107 mmol) of sodium nitrite dissolved in 15 mL of water was added dropwise. After the dropwise addition, stirring was continued for 45 minutes at a temperature range of -10 to -25°C. Maintaining the temperature of the reaction solution at about -25 °C, a mixture consisting of 100 mL of acetic acid saturated with sulfur dioxide and 2.5 g (25.3 mmol) cuprous chloride was added in batches, a process that required cooling to 10 °C in an ice bath. A large amount of nitrogen generation was observed during the reaction. The reaction mixture was brought back to room temperature and kept for 2 h. Subsequently, it was poured into 450 mL of ice-water mixture and extracted with ether. The ether extracts were combined, washed with saturated aqueous sodium bicarbonate, dried over sodium sulfate and concentrated. The resulting oily residue was distilled under reduced pressure to give 14.3 g (87% yield) of a liquid product consisting mainly of 2,5-difluorobenzenesulfonyl chloride with a boiling point of 65-70 °C (0.5 mmHg), which could be used in subsequent steps without further purification.
References
[1] Patent: US6509499, 2003, B1
[2] Journal of Chemical Information and Modeling, 2015, vol. 54, # 12, p. 3404 - 3416
2,5-DIFLUOROBENZENESULFONYL CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,5-DIFLUOROBENZENESULFONYL CHLORIDE manufacturers
- Product
- 2,5-DIFLUOROBENZENESULFONYL CHLORIDE 26120-86-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 100kg/week
- Release date
- 2019-08-05