LSZ-102
- Product Name
- LSZ-102
- CAS No.
- 2135600-76-7
- Chemical Name
- LSZ-102
- Synonyms
- LSZ-102;CS-2791;LSZ102;LSZ-102;LSZ 102;LSZ-102, 10 mM in DMSO;(2E)-3-[4-[[2-[2-(1,1-Difluoroethyl)-4-fluorophenyl]-6-hydroxybenzo[b]thien-3-yl]oxy]phenyl]-2-propenoic acid;2-Propenoic acid, 3-[4-[[2-[2-(1,1-difluoroethyl)-4-fluorophenyl]-6-hydroxybenzo[b]thien-3-yl]oxy]phenyl]-, (2E)-
- CBNumber
- CB74629486
- Molecular Formula
- C25H17F3O4S
- Formula Weight
- 470.46
- MOL File
- 2135600-76-7.mol
LSZ-102 Property
- Boiling point:
- 643.5±55.0 °C(Predicted)
- Density
- 1.418±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 4.49±0.10(Predicted)
- color
- White to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- DC10755
- Product name
- LSZ102
- Purity
- >98%
- Packaging
- 10mg
- Price
- $500
- Updated
- 2021/12/16
- Product number
- DC10755
- Product name
- LSZ102
- Purity
- >98%
- Packaging
- 25mg
- Price
- $900
- Updated
- 2021/12/16
LSZ-102 Chemical Properties,Usage,Production
Uses
is a potent, orally bioavailable selective estrogen receptor degrader currently being studied for the treatment of ERα positive breast cancer.
in vivo
Treatment of the mice with LSZ-102 once daily at 20 mg/kg results in significant tumor growth inhibition as compare to the control group treated with vehicle alone, resulting in tumor stasis (mean change in tumor volume of LSZ-102 vs control=%ΔT/ΔC of 2.4% on day 48, p<0.05). Dosing of 3 mg/kg solution of LSZ-102 in male Sprague-Dawley rats results in 33% bioavailability and a dose-normalized exposure of 620 nM h[1].
LSZ-102 Preparation Products And Raw materials
Raw materials
Preparation Products
LSZ-102 Suppliers
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- 025-83697070
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- +86-25-83453306
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- China
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- United States
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- +1 (732)236-3202
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- United States
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- QQ 3610331285
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- Tel
- 88888888888
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- Country
- China
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View Lastest Price from LSZ-102 manufacturers
- Product
- LSZ-102 2135600-76-7
- Price
- US $2.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-24