ChemicalBook > CAS DataBase List > 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea

1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea

Product Name
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea
CAS No.
941987-60-6
Chemical Name
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea
Synonyms
H-151;H 151 NEW;H 151 (H-151);STING inhibitor;STING antagonist;H-151 (STING inhibitor);1-(4-Ethylphenyl)-3-(3-indolyl)urea;N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea;H151;H-151;H-151;H-151;STING ANTAGONIST;1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea
CBNumber
CB74635441
Molecular Formula
C17H17N3O
Formula Weight
279.34
MOL File
941987-60-6.mol
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1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea Property

Boiling point:
399.9±25.0 °C(Predicted)
Density 
1.298±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Soluble in DMSO (25 mg/ml)
pka
14.96±0.70(Predicted)
form 
solid
color 
Off-white
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25857
Product name
H-151
Purity
≥98%
Packaging
5mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
25857
Product name
H-151
Purity
≥98%
Packaging
10mg
Price
$115
Updated
2024/03/01
Cayman Chemical
Product number
25857
Product name
H-151
Purity
≥98%
Packaging
50mg
Price
$537
Updated
2024/03/01
Cayman Chemical
Product number
25857
Product name
H-151
Purity
≥98%
Packaging
100mg
Price
$952
Updated
2024/03/01
Tocris
Product number
6675
Product name
H151
Purity
≥98%(HPLC)
Packaging
10
Price
$176
Updated
2021/12/16
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1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea Chemical Properties,Usage,Production

Description

H-151 (941987-60-6) is an inhibitor of the signaling molecule STING in mouse and human cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. It reduced systemic cytokine response in mice treated with the STING agonist 10-carboxymethyl-9-acridanone and showed efficacy in Trex-/- mice.

Uses

1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea (cas# 941987-60-6) is a useful research chemical. It is used in biological studies in the enhancement of transgene expression by beta-catenin inhibitor iCRT14.

storage

Store at +4°C

References

1) Haag et al. (2018), Targeting STING with covalent small-molecule inhibitors; Nature 559 269 2) Lee et al. (2019), STING restricts oHSV Replication and Spread in Resistant MPNSYs but Is Dispensable for Basal IFN-Stimulated Gene Upregulation; Mol. Ther. Oncolytics 15 91 [FOCUS Citation]

1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea Suppliers

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941987-60-6, 1-(4-ethylphenyl)-3-(1H-indol-3-yl)ureaRelated Search:

ZM 447439 LFM-A13 AG 490 (+)-Camptothecin

  • 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea
  • H151;H-151;H-151;H-151;STING ANTAGONIST
  • STING antagonist
  • N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea
  • H-151
  • H 151 NEW
  • Urea, N-(4-ethylphenyl)-N'-1H-indol-3-yl-
  • STING inhibitor
  • H 151 (H-151)
  • ERIS,phosphorylation,Stimulator of Interferon Genes,H-151,palmitoylatio,TMEM173,MPYS,inhibit,autoinflammatory,TBK1,STING,Inhibitor,MITA,H151,H 151
  • H-151 (STING inhibitor)
  • 1-(4-Ethylphenyl)-3-(3-indolyl)urea
  • 941987-60-6