2-Acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-5-thio-a-D-glucopyranose

Product Name: 2-Acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-5-thio-a-D-glucopyranose
CAS No.: 67561-97-1
Chemical Name: 2-Acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-5-thio-a-D-glucopyranose
Synonyms: 2-acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-5-thio-α-D-glucofuranose;2-Acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-5-thio-a-D-glucopyranose;2-acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-5-thio-α-D-glucopyranose;α-D-Glucopyranose, 2-(acetylamino)-2-deoxy-5-thio-, 1,3,4,6-tetraacetate
CBNumber: CB74656828
Molecular Formula: C16H23NO9S
Formula Weight: 405.42
MOL File: 67561-97-1.mol

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2-Acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-5-thio-a-D-glucopyranose Property

Boiling point:: 546.2±50.0 °C(Predicted)
Density: 1.31±0.1 g/cm3(Predicted)
pka: 13.37±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

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2-Acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-5-thio-a-D-glucopyranose Chemical Properties,Usage,Production

Uses

Ac4-5SGlcNAc is a pro-inhibitor of carbohydrate-based glycosyltransferases (OGTs). Ac4-5SGlcNAc inhibits o-GlcN acylation and interferes with the effects of o-GlcN on neural induction of human embryonic stem cells (hESCs), and reduces the invasive phenotype of breast cancer cells. Ac4-5SGlcNAc also targets other carbohydrate-processing enzymes[1].

References

[1] Barkovskaya A, et al. Inhibition of O-GlcNAc transferase activates tumor-suppressor gene expression in tamoxifen-resistant breast cancer cells. Sci Rep. 2020 Oct 12;10(1):16992. DOI:10.1038/s41598-020-74083-z
[2] Andres LM, et al. Chemical Modulation of Protein O-GlcNAcylation via OGT Inhibition Promotes Human Neural Cell Differentiation. ACS Chem Biol. 2017 Aug 18;12(8):2030-2039. DOI:10.1021/acschembio.7b00232

2-Acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-5-thio-a-D-glucopyranose Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-5-thio-a-D-glucopyranose Suppliers

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67561-97-1, 2-Acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-5-thio-a-D-glucopyranoseRelated Search:

2-Acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-5-thio-a-D-glucopyranose

2-acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-5-thio-α-D-glucofuranose

α-D-Glucopyranose, 2-(acetylamino)-2-deoxy-5-thio-, 1,3,4,6-tetraacetate

2-acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-5-thio-α-D-glucopyranose

67561-97-1