2-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole

Product Name: 2-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole
CAS No.: 1401728-56-0
Chemical Name: 2-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole
Synonyms: GPR4 antagonist 3;NE 52-QQ57 ，S6850;NE 52-QQ57, 10 mM in DMSO;GPR4 antagonist 3(NE 52-QQ57 );inhibit,NE 52 QQ57,NE 52-QQ-57,NE 52-QQ57,NE 52QQ57,Inhibitor;2-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole;Pyrazolo[1,5-a]pyrimidine, 2-ethyl-5,7-dimethyl-3-[[4-[5-(4-piperidinyl)-1,3,4-oxadiazol-2-yl]phenyl]methyl]-
CBNumber: CB74658413
Molecular Formula: C24H28N6O
Formula Weight: 416.52
MOL File: 1401728-56-0.mol

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2-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole Property

Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:10.0(Max Conc. mg/mL);24.1(Max Conc. mM)
Ethanol:45.0(Max Conc. mg/mL);108.0(Max Conc. mM)
form: Solid
pka: 9.56±0.10(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC20076
Product name: GPR4antagonist3(NE52-QQ57)
Purity: >98%
Packaging: 100mg
Price: $800
Updated: 2021/12/16

DC Chemicals

Product number: DC20076
Product name: GPR4antagonist3(NE52-QQ57)
Purity: >98%
Packaging: 250mg
Price: $1500
Updated: 2021/12/16

DC Chemicals

Product number: DC20076
Product name: GPR4antagonist3(NE52-QQ57)
Purity: >98%
Packaging: 1g
Price: $3000
Updated: 2021/12/16

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2-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole Chemical Properties,Usage,Production

Uses

NE 52-QQ57 is a selective, and orally available GPR4 antagonist with an IC50 of 70 nM. NE 52-QQ57 has anti-inflammatory activity[1].

in vivo

NE 52-QQ57 (Compound 13) shows a significant anti-inflammatory effect in the rat antigen induced arthritis model after oral administration at 30 mg/kg bid for 20 days^[1]. NE 52-QQ57 (30 mg/kg bid po for 4 days) also prevents angiogenesis in the mouse chamber model as well as pain as demonstrated in the rat complete Freund’s adjuvant model^[1].

Animal Model:	Female FVB mice (8-10 weeks)^[1]
Dosage:	30 mg/kg
Administration:	Oral, 4 days, bid
Result:	Treatment at 30 mg/kg p.o. bid starting on day 0, the day of the chamber implantation, showed a statistically significant reduction (46.8±10.6%) of tissue growth by day 4. The blood levels of 13 on day 4 at 2 and 16 h after compound application in this model were 9.03±2.87 and 0.09±0.06 μM^[1].

Animal Model:	Male Wistar Han rats^[1]
Dosage:	3, 10, and 30 mg/kg
Administration:	Oral, 20 days, bid
Result:	Displayed not only higher exposures in the rat AIA but also lower plasma protein binding in rat (95%)^[1].

References

[1] Velcicky J, et al. Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis. J Med Chem. 2017 May 11;60(9):3672-3683. DOI:10.1021/acs.jmedchem.6b01703
[2] Hosford PS, et al. CNS distribution, signalling properties and central effects of G-protein coupled receptor 4. Neuropharmacology. 2018 Aug;138:381-392. DOI:10.1016/j.neuropharm.2018.06.007

2-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole Preparation Products And Raw materials

Raw materials

Preparation Products

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1401728-56-0, 2-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazoleRelated Search:

2-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole

GPR4 antagonist 3

Pyrazolo[1,5-a]pyrimidine, 2-ethyl-5,7-dimethyl-3-[[4-[5-(4-piperidinyl)-1,3,4-oxadiazol-2-yl]phenyl]methyl]-

GPR4 antagonist 3(NE 52-QQ57 )

inhibit,NE 52 QQ57,NE 52-QQ-57,NE 52-QQ57,NE 52QQ57,Inhibitor

NE 52-QQ57, 10 mM in DMSO

NE 52-QQ57 ，S6850

1401728-56-0