Vabicaserin hydrochloride

Product Name: Vabicaserin hydrochloride
CAS No.: 887258-94-8
Chemical Name: Vabicaserin hydrochloride
Synonyms: SCA 136;Vabicaserin hydrochloride;Vabicaserin hydrochloride (SCA 136);Vabicaserin hydrochloride, 10 mM in DMSO;Vabicaserin hydrochloride (Synonyms: SCA 136);(9aR,12aS)-4,5,6,7,9,9a,10,11,12,12a-Decahydrocyclopenta[c][1,4]diazepino[6,7,1-ij]quinoline hydrochloride;SCA-136,inhibit,5-hydroxytryptamine Receptor,5-HT Receptor,Vabicaserin,Inhibitor,Serotonin Receptor,SCA136,Vabicaserin hydrochloride
CBNumber: CB74658655
Molecular Formula: C15H21ClN2
Formula Weight: 264.8
MOL File: 887258-94-8.mol

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Vabicaserin hydrochloride Property

storage temp.: Store at -20°C
solubility: DMSO : 75 mg/mL (283.24 mM); Water : 4 mg/mL (15.11 mM)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0034625
Product name: Vabicaserinhydrochloride
Purity: 98.99%
Packaging: 5mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0034625
Product name: Vabicaserinhydrochloride
Purity: 98.99%
Packaging: 10mg
Price: $750
Updated: 2021/12/16

ChemScene

Product number: CS-0034625
Product name: Vabicaserinhydrochloride
Purity: 98.99%
Packaging: 25mg
Price: $1500
Updated: 2021/12/16

ChemScene

Product number: CS-0034625
Product name: Vabicaserinhydrochloride
Purity: 98.99%
Packaging: 50mg
Price: $2100
Updated: 2021/12/16

ChemScene

Product number: CS-0034625
Product name: Vabicaserinhydrochloride
Purity: 98.99%
Packaging: 100mg
Price: $3300
Updated: 2021/12/16

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Vabicaserin hydrochloride Chemical Properties,Usage,Production

Uses

Treatment of schizophrenia.

in vivo

After a single oral dose of [¹⁴C]Vabicaserin at 50, 5, and 15 mg/kg, unchanged drug represents less than 19, 20, and 35% of total plasma radioactivity at all the time points examined in mice, rats, and dogs, respectively. The carbamoyl glucuronide (CG) represents approximately 7 to 36% of plasma radioactivity in mice and 2 to 28% of plasma radioactivity in dogs but is not detected in rat plasma after the single [¹⁴C]Vabicaserin dose. However, the CG is observed in rat plasma after multiple-dose administration of Vabicaserin at higher doses, and the CG is approximately 20 times less than Vabicaserin based on steady-state AUC_0-24 values. The estimated plasma AUC_0-24 ratios of CG to the parent drug are 1.5 and 1.7 in mice and dogs after the single [¹⁴C]Vabicaserin dose, respectively. The plasma AUC_0-24 ratios for the CG to Vabicaserin at steady state with doses used for safety assessment are less for mice (0.2-0.6) and slightly higher for dogs (1.8-4.0) compared with the single dose values. The CG is detected in dog urine in similar amounts to the parent drug, although it is not detected in mouse or rat urine after the single [¹⁴C]Vabicaserin dose. Radioactivity in a 0- to 24-h bile collection from rats receiving a 5 mg/kg [¹⁴C]Vabicaserin dose accounts for 19 and 24% of the administered dose in males and females, respectively. Although the CG is not detected in urine or feces of rats after a single oral administration, it represents an average of up to 30% of biliary radioactivity in male rats and 15% in female rats. In monkeys after a single oral 25-mg/kg dose of Vabicaserin, the plasma concentrations of the CG exceeded those of Vabicaserin at all the time points (2-24 h) postdose, although the amount of CG relative to Vabicaserin decreased by 24 h postdose, with ratios of 17.5 at 2 h and 1.7 at 24 h. The CG to Vabicaserin AUC_0-24 ratio of 12:1 indicates that the CG is a major metabolite in monkeys^[2].

IC 50

5-HT_2C Receptor: 8 nM (EC₅₀)

Vabicaserin hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Vabicaserin hydrochloride Suppliers

China 28 United States 3 Global 31

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887258-94-8, Vabicaserin hydrochlorideRelated Search:

Vabicaserin hydrochloride

Vabicaserin hydrochloride (Synonyms: SCA 136)

Vabicaserin hydrochloride (SCA 136)

SCA 136

SCA-136,inhibit,5-hydroxytryptamine Receptor,5-HT Receptor,Vabicaserin,Inhibitor,Serotonin Receptor,SCA136,Vabicaserin hydrochloride

(9aR,12aS)-4,5,6,7,9,9a,10,11,12,12a-Decahydrocyclopenta[c][1,4]diazepino[6,7,1-ij]quinoline hydrochloride

Vabicaserin hydrochloride, 10 mM in DMSO

887258-94-8